Results 71 to 80 of about 74,263 (243)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding [PDF]

, 2013
The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and
A Melck, A Okamoto, AM Groeger, BC Soares de Sa, BE Gould Rotheberg, C Michaloglou, C Pilon, CQ Zhu, David Andrew Gunn, DE Marra, Dudley Ferdinando, F Haller, F Haller, G Volgareva, H Lin, HA McKenzie, Hong Wu, J Chen, J Lukas, Jeffrey Pawlikowski, JW Rocco, K Cuschieri, K Nilsson, M Dray, M Schutte, Magdalena Sawicka, Peter David Adams, R Klaes, S Pavey, Sophia N. Karagiannis, SS Wang, Stephen Wilson, WH Liggett Jr, William Parish, Y Cheng   +34 more
core   +7 more sources

Effect of Different Temperatures on the Microbiological Status of Donkey Milk

Contemporary Agriculture, 2023
Donkey milk is usually sold for human consumption directly at farms and agricultural households and it is used in the raw state because of its well-known medicinal properties.
Knežević Suzana Vidaković, Vranešević Jelena, Lupulović Diana, Kartalović Brankica, Knežević Slobodan, Pajić Marija   +5 more
doaj   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

A Preliminary Assessment of HTST Processing on Donkey Milk

Veterinary Sciences, 2017
Due to increasing attention from consumers on non-bovine milk types, and to the increase in the number of small dairy donkey farms in Italy, farmers require more advanced and reliable processing devices, in order to guarantee a safe product of high ...
Marzia Giribaldi, Sara Antoniazzi, Gian Marco Gariglio, Alessandra Coscia, Enrico Bertino, Laura Cavallarin   +5 more
doaj   +1 more source

A Preliminary Study of Proteomic Analysis on Caseins and Whey Proteins in Donkey Milk from Xinjiang and Shandong of China

eFood, 2021
The proteomics of donkey milk from China’s major producing areas have not been well documented. To explore the protein profiles of donkey milk from China, this study preliminarily investigated caseins and whey proteins in products from two major ...
Wahafu Luoyizha, Bo Zeng, Hui Li, Xiaojun Liao   +3 more
doaj   +1 more source

A Proteomic Study on Donkey Milk [PDF]

Biochemistry & Analytical Biochemistry, 2012
In children with Cow Milk Protein Allergy (CMPA), when it is not possible to breast feed or to use cow milk, the clinical use of donkey milk is considered since several studies have demonstrated the high similarity of donkey milk compared to human milk.
VINCENZETTI, Silvia, Amici A., PUCCIARELLI, Stefania, VITA, Alberto, Micozzi D., CARPI, FRANCESCO MARTINO, POLZONETTI, Valeria, NATALINI, Paolo, POLIDORI, Paolo   +8 more
openaire   +2 more sources

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Donkey milk production: state of the art

Italian Journal of Animal Science, 2010
Milk is one of the most common causes of food allergies among children under one year of age. No specific therapy exists for this allergy, and thus the only feasible response is to avoid assumption of milk and derived products.
Silvia Vincenzetti, Pierluigi Mariani, Daniela Beghelli, Paolo Polidori   +3 more
doaj   +1 more source

Effect of extruded linseed on sarda donkey milk quality

Italian Journal of Animal Science, 2022
The aim of this work was to evaluate the effect of extruded linseed in donkey diet on milk yield, milk composition and milk fatty acids (FA) profile. Eight Sarda donkeys were allocated to two groups homogenous for milk yield (0.354 ± 124 kg/d), days in ...
Fabio Correddu, Silvia Carta, Antonio Mazza, Anna Nudda, Salvatore Pier Giacomo Rassu   +4 more
doaj   +1 more source