Results 81 to 90 of about 1,479,892 (242)

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Impact of diet and body composition on donor human milk: a cross-sectional pilot study

Portuguese Journal of Pediatrics
Introduction and Objectives: Donor human milk is recommended in Neonatal Intensive Care Units when maternal breast milk is unavailable. This study aimed to explore the association between the eating habits, body mass index, and body composition of human ...
Sara Lopes da Silva, Beatriz Teixeira, Susana Pissarra, Susana Fraga, Rita Moita, Henrique Soares, Cristina Martins, Cláudia Camila Dias, Diana e Silva   +8 more
doaj   +1 more source

Effect of Storage Time and Temperature on Components in Human Breast Milk

, 2008
Breastfeeding is the optimal nutrition for infants and is recommended for the first year of life by the American Academy of Pediatrics. However, mothers who return to work within this time period cannot always breastfeed on demand and often pump their ...
Fogleman, April Danielle
core  

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, EarlyView.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

A systematic review of contaminants in donor human milk

Maternal and Child Nutrition
Donor human milk (DHM) from a milk bank is the recommended feeding method for preterm infants when the mother's own milk (MOM) is not available. Despite this recommendation, information on the possible contamination of donor human milk and its impact on ...
Sionika Thayagabalu, Nicole Cacho, Sandra Sullivan, John Smulian, Adetola Louis‐Jacques, Marie Bourgeois, Henian Chen, Wasana Weerasuriya, Dominick J. Lemas   +8 more
doaj   +1 more source

Growth after implementing a donor breast milk program in neonates <33 weeks gestational age or birthweight <1500 grams: Retrospective cohort study. [PDF]

J Perinatol, 2023
Sanchez-Rosado M, Lair CS, Edwards A, Jacob T, Heyne R, Brown LS, Clark C, Nelson DB, Wyckoff MH, Kiefaber I, Verma D, Reis J, Burchfield PJ, Sepulveda P, Brion LP.   +14 more
europepmc   +1 more source

A Comparison of Nutritional Antioxidant Content in Breast Milk, Donor Milk, and Infant Formulas

, 2017
Human milk is the optimal food for human infants, including infants born prematurely. In the event that a mother of a hospitalized infant cannot provide breast milk, donor milk is considered an acceptable alternative.
Lyden, Elizabeth, Hanson, Corrine, Van Ormer, Matthew, Furtado, Jeremy, Anderson-Berry, Ann   +4 more
core   +1 more source

The Host Defense Proteome of Human and Bovine Milk [PDF]

, 2011
Milk is the single source of nutrients for the newborn mammal. The composition of milk of different mammals has been adapted during evolution of the species to fulfill the needs of the offspring.
Hooijdonk, A.C.M., van, Jacques Vervoort, Boeren, S., Hein van Valenberg, van Hooijdonk, A.C.M., Vervoort Jacques, van Valenberg Hein, Sacco de Vries, de Vries Sacco, Boeren Sjef, Hettinga Kasper, Vries, S.C., de, Valenberg, H.J.F., van, Hettinga, K.A., van Hooijdonk Toon, Kasper Hettinga, Sjef Boeren, de Vries, S.C., Arendonk, J.A.M., van, Toon van Hooijdonk, Johan van Arendonk, van Arendonk, J.A.M., van Arendonk Johan, Vervoort, J.J.M., van Valenberg, H.J.F.   +24 more
core   +2 more sources

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source