Results 121 to 130 of about 90,955 (259)

Bovine colostrum improves neonatal growth, digestive function, and gut immunity relative to donor human milk and infant formula in preterm pigs [PDF]

open access: bronze, 2016
Stine Rasmussen   +7 more
openalex   +1 more source

Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response

open access: yesAdvanced Science, EarlyView.
Wenxiang Meng and colleagues delve into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐
Ninan Zhang   +9 more
wiley   +1 more source

First Description of Discrete Stars Composing the Milk Way in Thomas Watson's Hekatompathia (1582) [PDF]

open access: yesarXiv, 2003
We note that the first unambiguous description of the Milk Way as being composed of a large number of discrete stars is in Sonnet 31 of Thomas Watson's (d 1592) Hekatompathia (1582), nearly 30 years before Galileo's description. We discuss implications of this early description.
arxiv  

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

open access: yesAdvanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo   +7 more
wiley   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

open access: yesAdvanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang   +8 more
wiley   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

open access: yesAdvanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu   +8 more
wiley   +1 more source

Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells [PDF]

open access: gold, 2019
Anna Parra‐Llorca   +9 more
openalex   +1 more source

Influence of donor profile on pre and post-pasteurization bacteriology of donated human milk

open access: gold, 2022
Marta Padín Fontán   +5 more
openalex   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

open access: yesAdvanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei   +18 more
wiley   +1 more source

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