Results 131 to 140 of about 90,955 (259)
Differential Effects of Mother’s Own Milk, Donor Human Milk and Formula Feeding on the Fecal Microbiota of Preterm Infants During Their Stay in the Neonatal Intensive Care Unit (FS04-06-19) [PDF]
, 2019 Miriam Aguilar‐López +6 more
openalex +1 more source
Advanced Science, EarlyView.A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang +16 more
wiley +1 more source
MiCull2 -- simulating mastitis transmission through milking order [PDF]
arXivContagious mastitis pathogens can be transmitted through milking. However, previously published simulation models, such as MiCull, have not directly taken this into account. We have reimplemented the MiCull model to model transmission of contagious mastitis pathogens through milking in a milking parlor. This additional complexity requires a substantial
arxiv
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun +10 more
wiley +1 more source
Advanced Science, EarlyView.This article demonstrates that maternal exercise or vitamin C supplementation during pregnancy enhance offspring muscle function by promoting mitochondrial biogenesis and oxidative fiber formation. This epigenetically driven improvement ultimately leads to higher endurance performance, strongly suggesting that sufficient maternal physical activity can ...
Haiwang Shi +14 more
wiley +1 more source
Fast Antibiotic resistance-Based gene editing of mammalian cells with CRISPR-Cas9 (FAB-CRISPR) [PDF]
arXivProtein tagging with CRISPR-Cas9 enables the investigation of protein function in its native environment but is limited by low homology-directed repair (HDR) efficiency causing low knock-in rates. We present a detailed pipeline using HDR donor plasmids containing antibiotic resistance cassettes for rapid selection of gene-edited cells.
arxiv
Artesunate Inhibits Neointimal Hyperplasia by Promoting IRF4 Associated Macrophage Polarization
Advanced Science, EarlyView.This study shows that macrophage interferon regulatory factor 4 (IRF4) improved arterial injury‐induced neointimal hyperplasia by promoting of M2 polarization via up‐regulating krüppel‐like factor 4 (KLF4) in rodent and nonhuman primate models. Notably, artesunate is identified as a potent inducer of IRF4 in macrophages, and proposed as a promising ...
Jinlin Miao +15 more
wiley +1 more source
Osmolality of fortified donor human milk: An experimental study
, 2023 Daphne Pineda +4 more
openalex +1 more source
Advanced Science, EarlyView.Trop2‐targeted CAR‐T cells experienced reduced efficacy and functional exhaustion at a low E:T ratio caused by mitophagy‐mediated mitochondrial dysfunction. Next, the mitophagy is screened agonist BC1618, which significantly strengthened the antitumor response of CAR‐T cells via improving the level of mitophagy, suggesting a promising approach to ...
Guodong Li +11 more
wiley +1 more source