Results 181 to 190 of about 153,544 (299)

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Human Milk Electrolytes as Nutritional Biomarkers of Mammary Gland Integrity: A Study Across Ductal Conditions and Donor Milk. [PDF]

Nutrients
Hsieh PY, Tanaka M, Himi T, Mizuno K.
europepmc   +1 more source

The Body in Question: The Income Tax and Human Body Materials [PDF]

, 2017
Zelenak, Lawrence
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Immune development differs between preterm newborns fed mothers' own milk and donor milk. [PDF]

iScience
Tan Z, Zhong W, Danielsson H, Arzoomand A, Lakshmikanth T, Chen Q, Mikes J, Wang J, Chen Y, James A, Nilsson AK, Elfvin A, Brusselaers N, Portlock T, Lundgren P, Sävman K, Wackernagel D, Hansen-Pupp I, Ley D, Uhlén M, Hellström A, Brodin P.   +21 more
europepmc   +1 more source

Combination of High-Pressure Processing and Freeze-Drying as the Most Effective Techniques in Maintaining Biological Values and Microbiological Safety of Donor Milk. [PDF]

Int J Environ Res Public Health, 2021
Jarzynka S, Strom K, Barbarska O, Pawlikowska E, Minkiewicz-Zochniak A, Rosiak E, Oledzka G, Wesolowska A.   +7 more
europepmc   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

EGF and IgA in maternal milk, donor milk, and milk fortifiers in the neonatal intensive care unit setting. [PDF]

PLoS One
Tamar C, Greenfield K, McDonald K, Levy E, Brumbaugh JE, Knoop K.   +5 more
europepmc   +1 more source

Supplementation Practices and Donor Milk Use in US Well-Newborn Nurseries. [PDF]

Hosp Pediatr, 2020
Kair LR, Phillipi CA, Lloyd-McLennan AM, Ngo KM, Sipsma HL, King BA, Flaherman VJ.   +6 more
europepmc   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source