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ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Neuronal Cholesterol Deficiency Mediated by Astrocytic SREBP2 Downregulation Leads to Postoperative Cognitive Dysfunction Through Impairment of Hippocampal Synaptic Plasticity and Excitatory Synaptic Transmission

Advanced Science, EarlyView.
The results showed that the reduction of plasma 24‐hydroxycholesterol (24‐OHC) was related to the cognitive decline in elderly surgical patients. Neuroinflammation induced by anesthesia and surgery significantly downregulated SREBP2 in hippocampal reactive astrocytes, resulting in reduced cholesterol synthesis.
He Huang, Chenrui Zhou, Chen Chen, Huimei Tang, Wei Dong, Jie Wan, Weiye Kang, Ao Sun, Yiqi Liu, Chunhui Jin, Xiaobin Lyu, Yankun Zhu, Chenghua Zhou, Yuqing Wu   +13 more
wiley   +1 more source

Fat composition in infant formula contributes to the severity of necrotising enterocolitis [PDF]

, 2018
Das, Tapas, Fulton, William B, Good, Misty, Hackam, David J, Jia, Hongpeng, Lai, Chron-Si, Lu, Peng, Ozolek, John A, Prindle, Thomas, Jr, Sodhi, Chhinder P, Vurma, Mustafa, Yamaguchi, Yukihiro   +11 more
core   +1 more source

Evaluating the Effect of Random Multi-Donor Pooling on the Nutritional Variability in Donor Human Milk Using Computer Modeling. [PDF]

Matern Child Nutr
Smith RM, Richter S, Iwayemi EF, Mansen K, Israel-Ballard K, Hampel D, Shahab-Ferdows S, Allen LH, Bode L, Perrin MT.   +9 more
europepmc   +1 more source

Effects of Holder Pasteurization on 15-F2t-Isoprostane and Total Antioxidant Power in Donor Human Milk. [PDF]

Biomolecules
Bellisario V, El Sherbiny S, Squillacioti G, Spadavecchia A, Punziano E, Coscia A, Peila C, Bono R.   +7 more
europepmc   +1 more source

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Microbiological Screening of Donor Human Milk

Breastfeeding Medicine, 2023
Mother's own milk is recognized as the optimal feeding not only for term but also for preterm infants. In addition to risk reduction for sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity in the early infancy, feeding preterm infants with mother's own milk is also associated with a better neurodevelopmental ...
Christine Schreiner, Andreas Müller, Till Dresbach   +2 more
openaire   +2 more sources