Results 241 to 250 of about 59,353 (290)

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

Advanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen, Zhidong Liu, Yanhang Sun, Xiaojun Xu, Zhexiao Lan, Junhao Zhao, Peitao Xu, Guiwen Ye, Jinteng Li   +8 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Peer-to-Peer Milk Donors' and Recipients' Experiences and Perceptions of Donor Milk Banks

Journal of Obstetric, Gynecologic & Neonatal Nursing, 2013
To explore the intersection of peer-to-peer milk sharing and donor milk banks.A descriptive survey design containing closed and open-ended questions was used to examine women's perceptions of peer-to-peer milk sharing and milk banking. Closed-ended questions were analyzed using descriptive statistics and conventional qualitative content analysis was ...
Gribble, Karleen D. (R12152)
openaire   +4 more sources

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Cytomegalovirus in Breast Milk of Swedish Milk Donors

Scandinavian Journal of Infectious Diseases, 1985
81 milk samples collected from 35 donors 3 days to 7 months after delivery were examined for the occurrence of cytomegalovirus (CMV). 30/35 (89%) of the women were seropositive to CMV. The virus was only found in samples from seropositive women collected greater than 8 days to less than 3 months after partus.
K, Ahlfors, S A, Ivarsson
openaire   +2 more sources

Characterization of Human Milk Donors

Journal of Human Lactation, 2007
The primary objective of this research was to create a detailed characterization of human milk donors, including descriptive information about demographics and lifestyle, involvement with the milk bank, reasons for donating, problems encountered while breastfeeding and pumping milk, barriers to donating milk, affective experiences, and personal values.
Richard, Osbaldiston, Leigh A, Mingle
openaire   +2 more sources

DONOR BREAST MILK

Acta Paediatrica, 1982
Baum, J. D. (University Department of Paediatrics, John Radcliffe Hospital, Oxford, U.K.). Donor breast milk. Acta Paediatr Scand, Suppl. 299:51, 1982.—A simple system for the collection and storage of human milk, as a voluntary community activity, is described.
openaire   +2 more sources

Human Donor Milk in Maternity

British Journal of Midwifery, 2023
Ines Salmoral and Denise McGuinness reflect on whether human donor milk should be made available for healthy term infants in the maternity setting
Ines Salmoral, Denise McGuinness
openaire   +1 more source

Donor Milk Banking and Breastfeeding in Norway

Journal of Human Lactation, 2009
Milk banks in Norway have a long tradition of using raw milk. This is a practice the authors hope to continue as they see it as the best choice until a child's own mothers' milk production is sufficient. Not only will the premature babies benefit from having milk from the bank, but if a mother, for any reason, can not supply her baby while it's in the ...
Anne Hagen, Grøvslien, Morten, Grønn
openaire   +2 more sources