Results 61 to 70 of about 8,606 (193)

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Chyle Leak following Open Donor Nephrectomy: A Rare Complication—A Case Report

Case Reports in Transplantation, 2012
Introduction. Donor workup in renal transplantation is extensive. Despite this, chyle leakage following donor nephrectomy, a rare complication, has been reported in the literature.
Sandeep Harkar, Dharam Vir Singh, Sanjay Kumar Gupta, Raghav Talwar, Yajvender Pratap Singh Rana   +4 more
doaj   +1 more source

Laparoendoscopic single-site donor nephrectomy

Indian Journal of Urology, 2012
A donor would prefer a minimally invasive procedure because of lesser morbidity, this may be the reason that laparoscopic donor nephrectomy (LDN) rates have exponentially increased.
Arvind P Ganpule, Shashikant Mishra, Ravindra Sabnis   +2 more
doaj   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Intraoperative Encounter of Double Inferior Vena Cava during Laparoscopic Left Donor Nephrectomy

Indian Journal of Transplantation
Duplication of the inferior vena cava (IVC) is a rare congenital vascular anomaly with a reported incidence of 0.1%–3.5%. It is usually asymptomatic and often detected incidentally on imaging or during surgery.
Indernath Verma, Anand Mohan, Ankita Sharma, Rajat Arora   +3 more
doaj   +1 more source

Retroperitoneal less donor nephrectomy

International Brazilian Journal of Urology, 2010
Donor nephrectomy with laparo-endoscopic single site (LESS) surgery has been reported via the transperitoneal approach. We describe a novel technique of retroperitoneal donor nephrectomy using a single surgical incision in the groin, below the abdominal ...
A. Van Der Merwe, A. Bachmann, C. F. Heyns   +2 more
doaj   +1 more source

Toward a digital urinary biopsy for early risk stratification in diabetic kidney disease: Anchoring shed cells, vesicles, and cell‐free DNA to spatial kidney cell states

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
In diabetic kidney disease, one urine specimen carries shed cells, extracellular vesicles and cell‐free DNA released along the whole nephron. Reading all three against spatial kidney atlases is proposed as a testable route to cell‐resolved, non‐invasive risk stratification, and the clinical outputs shown are not yet demonstrated.
Juan Wu, Ping Sheng, Ying Lu, Ke Chen
wiley   +1 more source

Effect of Melatonin on 24‐Hour Urinary Protein Excretion and Sleep Quality in Patients With Stage 3–4 Chronic Kidney Disease: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial

Health Science Reports, Volume 9, Issue 11, November 2026.
ABSTRACT Background and Aims Proteinuria is an established marker of renal injury and is closely associated with adverse outcomes in chronic kidney disease (CKD). Melatonin has attracted interest as a potential renoprotective agent because of its antioxidant, anti‐inflammatory, and regulatory effects on several pathways implicated in kidney injury ...
Shadi Ziaie, Behnam Mahdavi, Fatemeh Pourrezagholi, Aylar Nadiri Niri, Mohammad Abbasinazari, Roja Asadpour   +5 more
wiley   +1 more source