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Current Biology, 2022
Dopamine was first described by George Barger, James Ewens, and Henry Dale in 1910 as an epinephrine-like monoamine compound. Initially believed to be a mere precursor of norepinephrine, it was mostly ignored for the next four decades (Figure 1A). However, in the 1950s Kathleen Montagu showed that dopamine occurred in the brain by itself, and a series ...
Kauê Machado, Costa +1 more
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Dopamine was first described by George Barger, James Ewens, and Henry Dale in 1910 as an epinephrine-like monoamine compound. Initially believed to be a mere precursor of norepinephrine, it was mostly ignored for the next four decades (Figure 1A). However, in the 1950s Kathleen Montagu showed that dopamine occurred in the brain by itself, and a series ...
Kauê Machado, Costa +1 more
openaire +2 more sources
The Lancet, 1976
The antipsychotic actions and extra-pyramidal side-effects of neuroleptic drugs are strongly correlated with their ability to block central dopaminergic transmission. It is argued that the former are more closely related to actions on dopaminergic mechanisms in the "mesolimbic dopamine" system, and the latter to similar actions in the striatum ...
Jakob Korf, BenH.C. Westerink
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The antipsychotic actions and extra-pyramidal side-effects of neuroleptic drugs are strongly correlated with their ability to block central dopaminergic transmission. It is argued that the former are more closely related to actions on dopaminergic mechanisms in the "mesolimbic dopamine" system, and the latter to similar actions in the striatum ...
Jakob Korf, BenH.C. Westerink
+16 more sources
Dopamine receptors: from structure to function.
Physiological Reviews, 1998The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes. Two D1-like receptor subtypes (D1 and D5) couple to the G protein Gs and activate adenylyl cyclase.
C. Missale +4 more
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Dopamine and non-dopamine psychoses
Psychopharmacology, 1984The time course of antipsychotic response following the initiation of an antipsychotic drug and functional dopamine receptor sensitivity were explored in a cohort of recently admitted psychotic (mood-incongruent) patients. The distribution of the latencies of antipsychotic response suggested at least two populations.
David L. Garver +4 more
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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons.
Science, 1990The striatum, which is the major component of the basal ganglia in the brain, is regulated in part by dopaminergic input from the substantia nigra. Severe movement disorders result from the loss of striatal dopamine in patients with Parkinson's disease ...
C. Gerfen +6 more
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The Physiology, Signaling, and Pharmacology of Dopamine Receptors
Pharmacological Reviews, 2011G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension ...
J. Beaulieu, R. Gainetdinov
semanticscholar +1 more source
Science, 1997
Ingrid Wickelgren's Special News Report “Getting the brain's attention” ([3 Oct., p. 35][1]) presents the views of those who question the current orthodoxy that dopamine acts in the nucleus accumbens as a key neurotransmitter underlying the behavioral effects of positive reinforcement or ...
Jeffrey A. Gray +2 more
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Ingrid Wickelgren's Special News Report “Getting the brain's attention” ([3 Oct., p. 35][1]) presents the views of those who question the current orthodoxy that dopamine acts in the nucleus accumbens as a key neurotransmitter underlying the behavioral effects of positive reinforcement or ...
Jeffrey A. Gray +2 more
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Journal of Neural Transmission, 1993
The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters, most notably norepinephrine, serotonin, and acetylcholine, in the pathogenesis of depression, have focused attention away from substantial evidence implicating dopamine in affective disorders.
Samuel Gershon, A. S. Brown
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The dopamine hypothesis of schizophrenia and the emphasis on other neurotransmitters, most notably norepinephrine, serotonin, and acetylcholine, in the pathogenesis of depression, have focused attention away from substantial evidence implicating dopamine in affective disorders.
Samuel Gershon, A. S. Brown
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Dopamine turnover estimated by simultaneous LCEC assay of dopamine and dopamine metabolites
Journal of Pharmacological Methods, 1982The estimation of changes in tissue levels of dopamine (DA) and its metabolites has been employed to approximate the turnover rate or release of DA. We have developed an assay using high pressure liquid chromatography with electrochemical detection to quantify DA, dihydroxyphenylacetic acid (DOPAC), 3-methoxytyramine (3-MT), and homovanillic acid (HVA)
C.H. Cheng, G.F. Wooten
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