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A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

Advanced Science, EarlyView.
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu, Zhenbo Yuan, Yue Gao, Fei Li, Zhiwei Deng, Yan Zhang, Zhengshan Luo, Changmei Liu, Yijian Rao   +8 more
wiley   +1 more source

Differential regulation of long noncoding RNAs by endogenous and exogenous reactive oxygen species-generating prooxidants in NIH3T3 cells. [PDF]

PLoS One
Kurokawa Y, Honda T, Fujii S, Narisawa Y, Ogawa H, Kawashima H, Tani H.   +6 more
europepmc   +1 more source

Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans: A Systematic Review and Meta-Analysis. [PDF]

JAMA Psychiatry
Mkrtchian A, Qiu Z, Abir Y, Erdmann T, Dercon Q, Sedlinska T, Browning M, Costello H, Huys QJM.   +8 more
europepmc   +1 more source

Striatal dopaminergic patterns and clinical features in frontotemporal dementia. [PDF]

Brain Commun
Urso D, Anastasia A, Gnoni V, Giugno A, Vilella D, Vitulli A, Zecca C, Pineda-Pardo JA, Foffani G, Obeso JA, Logroscino G.   +10 more
europepmc   +1 more source

Dopamine modulation of motor and implicit learning contributions to auditory temporal attention

Zalta A, Spitz L, Schnitzler PA, Morillon B, Florin E.   +4 more
europepmc   +1 more source

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Dopamine

Current Biology, 2022
Dopamine was first described by George Barger, James Ewens, and Henry Dale in 1910 as an epinephrine-like monoamine compound. Initially believed to be a mere precursor of norepinephrine, it was mostly ignored for the next four decades (Figure 1A). However, in the 1950s Kathleen Montagu showed that dopamine occurred in the brain by itself, and a series ...
Kauê Machado, Costa, Geoffrey, Schoenbaum   +1 more
openaire   +2 more sources