Results 71 to 80 of about 118,448 (336)

Dopamine genetic risk score predicts impulse control behaviors in Parkinson’s disease

Clinical Parkinsonism & Related Disorders, 2021
Introduction: Up to 40% of Parkinson’s disease patients taking dopamine agonist medication develop impulse control behaviors which can have severe negative consequences.
Alison Hall, Samuel R. Weaver, Lindsey J. Compton, Winston D. Byblow, Ned Jenkinson, Hayley J. MacDonald   +5 more
doaj  

Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism [PDF]

, 2010
Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia.
Andrew R. Tapper, Bruce N. Cohen, Coward D. M., Franklin K. B. J., Henry A. Lester, Herwig Just, Janssen P. A., Lester H. A., Mercuri N. B., Outi Salminen, Paul D. Gardner, Paul Whiteaker, Raz A., Rubing Zhao-Shea, Salminen O., Sharon R. Grady, Sotnikova T. D., Tapper A. R., Tristan McClure-Begley   +18 more
core   +3 more sources

Dopamine Agonists in Parkinson’s Disease [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984
ABSTRACTDopamine agonists have yielded two important advances to our understanding of the basal ganglia – they have facilitated the subdivision of different classes of dopamine receptors, and they have established the fact that important dopaminergic effects can be achieved by activation of dopamine receptors in a manner that is unrelated to anoxal ...
Donald B. Calne, Jeff Beckman, W.R. Wayne Martin, Keith Burton   +3 more
openaire   +2 more sources

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Effect of the TAAR1 Partial Agonist Ralmitaront on Presynaptic Dopamine Synthesis Capacity Measured Using [F]DOPA PET in Naïve and Cocaine-Treated Mice

Molecular Imaging
Purpose Elevated dopamine synthesis capacity is part of the pathophysiology of schizophrenia thought to underlie psychosis. Drugs that reduce this phenomenon could thus be potential treatments for these disorders.
David R. Bonsall PhD, Michelle Kokkinou PhD, Els F. Halff PhD, Grazia Rutigliano PhD, Sac-Pham Tang MSc, Mattia Veronese PhD, Elaine E. Irvine PhD, Dominic J. Withers FRCP, PhD, Lisa A. Wells PhD, Sridhar Natesan PhD, Irene Gerlach PhD, Štefan Holiga PhD, Marius C. Hoener PhD, Oliver D. Howes MRCpsych, PhD   +13 more
doaj   +1 more source

Cabergoline-induced mania in a patient of pituitary microadenoma

Indian Journal of Psychological Medicine, 2017
Cabergoline, a dopamine agonist agent, is commonly used in the treatment of hyperprolactinemia, Parkinson's disease, restless leg syndrome, and antipsychotic-induced prolactin elevation.
Satyakam Mohapatra, Mihir Ranjan Nayak
doaj   +1 more source

Levo-Tetrahydropalmatine Attenuates Cocaine Self-Administration under a Progressive-Ratio Schedule and Cocaine Discrimination in Rats [PDF]

, 2010
Levo-tetrahydropalmatine (l-THP) is an alkaloid found in many traditional Chinese herbal preparations and has a unique pharmacological profile that includes dopamine receptor antagonism.
Baker, David A., Becker, Amanda, Li, Shi-Jiang, Mantsch, John R., Peters, Corey, Valentine, Abbey, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +8 more
core   +2 more sources

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, EarlyView.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury

Advanced Science, EarlyView.
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley   +1 more source

A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease [PDF]

, 2013
Copyright © 2013 IBRO. Published by Elsevier Ltd.
Barak, Basu-Modak, Bishop-Bailey, Breidert, Chen, Chen, Chopra, Ciesielska, Czlonkowska, Dauer, Dehmer, Delerive, Desvergne, Devchand, Dong, Escribano, H.L. Martin, Hsieh, Hébert, Iwashita, Jackson-Lewis, K. Sathe, Kalinin, Kreisler, Long-Smith, Luquet, M.C. Nelson, Martin, McGeer, Mogi, Mogi, Nicolakakis, Niino, Nuber, P. Teismann, Pascal, Polak, R.B. Mounsey, R.M. Evans, Ricote, S. Mustafa, Santos, Schintu, Shearer, Shi, Storer, Sznaidman, Takahashi, Teismann, Tian, Wang, West, Wu, Xu, Xu, Yacoub, Yi   +56 more
core   +1 more source