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Antiemetic specificity of dopamine antagonists
Psychopharmacology, 1982Twelve antagonists of apomorphine-induced emesis in dogs were studied in different tests to evaluate their antiemetic specificity. Ten of these antagonists were neuroleptics: benzquinamide, clebopride, bromopride, prochlorperazine, haloperidol, chlorpromazine, thiethylperazine, metoclopramide, droperidol, and pimozide blocked conditioned responding in ...
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Dopamine antagonists and migraine
Drug Development Research, 2007AbstractMigraine is common impairing disorder resulting from activation of the trigeminovascular system. Evidence suggests that dopaminergic mechanisms are important in migraine, including the premonitory phase. Dopamine antagonists have been used successfully as a primary therapy for migraine in urgent care settings and as adjuvant therapy on an ...
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Charged analogs of chlorpromazine as dopamine antagonists
Journal of Medicinal Chemistry, 1987Chlorpromazine (1, CPZ) is a potent dopamine antagonist that has been used widely as an antipsychotic agent. Since dopaminergic antagonists, like dopaminergic agonists, exist in solution as the charged and uncharged molecular species, it is not clear which form of the amine is most important for interaction with the dopamine receptor.
M W, Harrold +6 more
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Dopamine D3 receptor antagonists as therapeutic agents
Drug Discovery Today, 2005The behavioral and pathophysiological role of the dopamine D(3) receptor, which was deduced from anatomical, lesion and drug treatment studies in the ten years following cloning of the receptor, indicated that its functions differed from those of the D(2) receptor.
Jeffrey N, Joyce, Mark J, Millan
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Selective dopamine antagonists reduce nicotine self-administration
Psychopharmacology, 1991The effects of selective D1 (SCH23390) and D2 (spiperone) dopamine antagonists, as well as of haloperidol, were examined on nicotine self-administration, food-maintained responding, and locomotor activity in rats. Antagonists reduced both operant responding and locomotor activity.
W A, Corrigall, K M, Coen
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Highlights of D1 dopamine receptor antagonist research
Neurochemistry International, 1992SCH 39166 is now undergoing clinical trials in schizophrenics as a selective D1 dopamine receptor antagonist. It differs from SCH 23390, the prototype D1 receptor antagonist, by having reduced affinity for serotonin receptors and a longer duration of action in primates, as measured in the squirrel monkey conditioned avoidance paradigm.
A, Barnett, R D, McQuade, C, Tedford
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[Dopamine antagonists in anovulation?].
Zentralblatt fur Gynakologie, 1991Increased hypothalamic dopamine turnover may prevent the ovulatory LH peak by different mechanisms and may in this way result in anovulation. Ten patients with anovulatory menstrual cycles who had been treated with clomiphene citrate without success were given the dopaminolytic drug pimozide (Antalon) at a dose of 5 mg/day orally either from day 7 to ...
U, Ulrich +4 more
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European Neuropsychopharmacology, 1991
Animal data suggest that a D1 antagonistic component in neuroleptic drugs counteracts development of dopamine supersensitivity and of tolerance to cataleptic effect. This has led to the hypothesis that neuroleptics with D1 antagonistic activity should cause a better suppression of tardive dyskinesia (TD) and less rebound aggravation after withdrawal ...
H, Lublin +7 more
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Animal data suggest that a D1 antagonistic component in neuroleptic drugs counteracts development of dopamine supersensitivity and of tolerance to cataleptic effect. This has led to the hypothesis that neuroleptics with D1 antagonistic activity should cause a better suppression of tardive dyskinesia (TD) and less rebound aggravation after withdrawal ...
H, Lublin +7 more
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Selective Dopamine D1 and D2 Receptor Antagonists
1989The concept of selective dopamine D1 and D2 receptor antagonists is rather new. Previously, dopamine receptor antagonism was evaluated simply as the ability to inhibit dopamine- or dopamine agonist-mediated behaviour or biochemical responses. In 1979 Kebabian and Calne introduced the dopamine D1 and D2 receptor concept based on differential linkage to ...
J, Hyttel, J, Arnt, M, van den Berghe
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Dopamine D3 Receptor Ligands with Antagonist Properties
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Anneke E, Hackling, Holger, Stark
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