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Selective dopamine D4 receptor antagonists
Expert Opinion on Therapeutic Patents, 1998The discovery that the atypical antipsychotic clozapine has higher affinity for the dopamine D4 receptor relative to the D2 receptor touched off a search for more potent, highly selective D4 antagonists as a new class of antipsychotics. Many compounds achieving high potency and selectivity are now available including L-745,870 (Merck), NGD 94-1 ...
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Classification of dopamine-antagonists from pharmacological data
Life Sciences, 1978Abstract A graphical method is described that allows to classify the dopamine- antagonists on the basis of three pharmacological observations. The so-called spectral map represents the relative affinities of these drugs for three receptor sites.
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DOPAMINE ANTAGONISTS FOR NAUSEA AND VOMITING
Gastroenterology Nursing, 2014The dopamine antagonists, particularly droperidol, are effective at treating N&V. Because dopamine plays many roles in the body, especially in the brain, a degree of alteration in mental status should be expected, especially with higher doses. Other less frequent side effects include QT prolongation.
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Calcium Antagonists, Neuroleptics and Brain Dopamine
1988Aside from the blockade induced by calcium channel antagonist (CCA) drugs on excitable tissue, there appears to be a role for CCA in dopamine (DA) function as demonstrated by verapamil (VER) inhibition of DA release from the arcuate nucleus (DiRenzo et al.,1984), their benefit in the treatment of movement disorders (Goldstein, 1984), the direct ...
Bruce I. Diamond +2 more
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Metoclopramide: a dopamine receptor antagonist.
American family physician, 1990A dopamine receptor antagonist, metoclopramide has unique properties of increasing lower esophageal sphincter pressure and increasing the rate of gastric emptying. These gastrointestinal motility actions are useful in the treatment of diabetic gastroparesis and severe gastroesophageal reflux and in postoperative situations involving visceral atony ...
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