Results 1 to 10 of about 673,565 (253)

The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension

Biomedicines, 2021
The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension.
Waleed N. Qaddumi, Pedro A. Jose
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Dopamine in Health and Disease: Much More Than a Neurotransmitter

Biomedicines, 2021
Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors ...
Rafael Franco, Irene Reyes-Resina, Gemma Navarro   +2 more
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Decoding the dopamine signal in macaque prefrontal cortex: a simulation study using the Cx3Dp simulator. [PDF]

PLoS ONE, 2013
Dopamine transmission in the prefrontal cortex plays an important role in reward based learning, working memory and attention. Dopamine is thought to be released non-synaptically into the extracellular space and to reach distant receptors through ...
Isabelle Ayumi Spühler, Andreas Hauri
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Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages [PDF]

PeerJ, 2018
Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of ...
Juan C. Opazo, Kattina Zavala, Soledad Miranda-Rottmann, Roberto Araya   +3 more
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Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?

Frontiers in Pharmacology, 2022
Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao, Fangyi Zhao, Ziqian Cheng, Ziqian Cheng, Jingjing Piao, Jingjing Piao, Ranji Cui, Ranji Cui, Bingjin Li, Bingjin Li   +9 more
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Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors

Journal of Pharmacological Sciences, 2012
Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson’s disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with
Hiroko Ikeda, Junzo Kamei, Noriaki Koshikawa, Alexander R. Cools   +3 more
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Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Molecular Brain, 2021
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima   +6 more
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Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats. [PDF]

PLoS ONE, 2013
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus ...
Chen Yang, Shun-Nan Ge, Jia-Rui Zhang, Lei Chen, Zhi-Qiang Yan, Li-Jun Heng, Tian-Zhi Zhao, Wei-Xin Li, Dong Jia, Jun-Ling Zhu, Guo-Dong Gao   +10 more
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Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

PLoS ONE, 2013
Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals.
Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada   +8 more
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Dopamine Modulates Drosophila Gut Physiology, Providing New Insights for Future Gastrointestinal Pharmacotherapy

Biology, 2021
Dopamine has a variety of physiological roles in the gastrointestinal tract (GI) through binding to Drosophila dopamine D1-like receptors (DARs) and/or adrenergic receptors and has been confirmed as one of the enteric neurotransmitters.
Samar El Kholy, Kai Wang, Hesham R. El-Seedi, Yahya Al Naggar   +3 more
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