Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression? [PDF]
Frontiers in Pharmacology, 2022 Dopamine and its receptors are currently recognized targets for the treatment of several neuropsychiatric disorders, including Parkinson’s disease, schizophrenia, some drug use addictions, as well as depression.
Fangyi Zhao +9 more
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Dopamine receptors and organ fibrosis [PDF]
Biochemistry and Biophysics ReportsOrgan fibrosis, considered as a major global health concern, is a pathological condition often occurring after tissue injury in various organs. The pathogenesis of fibrosis involves multiple phases and multiple cell types. Dopamine is involved in various
ZhongLi Liao +3 more
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Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions [PDF]
Pharmaceuticals, 2023 Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement.
Diego Guidolin +6 more
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Journal of Experimental Neuroscience, 2018 Dopamine controls various physiological functions in the brain and periphery by acting on its receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors involved in the regulation of motor activity and several neurological ...
Akanksha Mishra +2 more
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Synaptic enrichment and dynamic regulation of the two opposing dopamine receptors within the same neurons [PDF]
eLifeDopamine can play opposing physiological roles depending on the receptor subtype. In the fruit fly Drosophila melanogaster, Dop1R1 and Dop2R encode the D1- and D2-like receptors, respectively, and are reported to oppositely regulate intracellular cAMP ...
Shun Hiramatsu +6 more
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The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension
Biomedicines, 2021 The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension.
Waleed N. Qaddumi, Pedro A. Jose
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Dopamine in Health and Disease: Much More Than a Neurotransmitter
Biomedicines, 2021 Dopamine is derived from an amino acid, phenylalanine, which must be obtained through the diet. Dopamine, known primarily to be a neurotransmitter involved in almost any higher executive action, acts through five types of G-protein-coupled receptors ...
Rafael Franco +2 more
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Dopamine Receptor Signaling [PDF]
Journal of Receptors and Signal Transduction, 2004 The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf ...
Kim A, Neve +2 more
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Decoding the dopamine signal in macaque prefrontal cortex: a simulation study using the Cx3Dp simulator. [PDF]
PLoS ONE, 2013 Dopamine transmission in the prefrontal cortex plays an important role in reward based learning, working memory and attention. Dopamine is thought to be released non-synaptically into the extracellular space and to reach distant receptors through ...
Isabelle Ayumi Spühler, Andreas Hauri
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Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages [PDF]
PeerJ, 2018 Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of ...
Juan C. Opazo +3 more
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