Results 11 to 20 of about 128,837 (259)

Evolution of dopamine receptors: phylogenetic evidence suggests a later origin of the DRD2l and DRD4rs dopamine receptor gene lineages [PDF]

PeerJ, 2018
Dopamine receptors are integral membrane proteins whose endogenous ligand is dopamine. They play a fundamental role in the central nervous system and dysfunction of dopaminergic neurotransmission is responsible for the generation of a variety of ...
Juan C. Opazo, Kattina Zavala, Soledad Miranda-Rottmann, Roberto Araya   +3 more
doaj   +2 more sources

Dopamine Receptor Signaling [PDF]

Journal of Receptors and Signal Transduction, 2004
The D1-like (D1, D5) and D2-like (D2, D3, D4) classes of dopamine receptors each has shared signaling properties that contribute to the definition of the receptor class, although some differences among subtypes within a class have been identified. D1-like receptor signaling is mediated chiefly by the heterotrimeric G proteins Galphas and Galphaolf ...
Kim A, Neve, Jeremy K, Seamans, Heather, Trantham-Davidson   +2 more
openaire   +2 more sources

Nucleus Accumbens and Dopamine-Mediated Turning Behavior of the Rat: Role of Accumbal Non-dopaminergic Receptors

Journal of Pharmacological Sciences, 2012
Accumbal dopamine plays an important role in physiological responses and diseases such as schizophrenia, Parkinson’s disease, and depression. Since the nucleus accumbens contains different neurotransmitters, it is important to know how they interact with
Hiroko Ikeda, Junzo Kamei, Noriaki Koshikawa, Alexander R. Cools   +3 more
doaj   +1 more source

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Molecular Brain, 2021
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima   +6 more
doaj   +1 more source

Systemic blockade of dopamine D2-like receptors increases high-voltage spindles in the globus pallidus and motor cortex of freely moving rats. [PDF]

PLoS ONE, 2013
High-voltage spindles (HVSs) have been reported to appear spontaneously and widely in the cortical-basal ganglia networks of rats. Our previous study showed that dopamine depletion can significantly increase the power and coherence of HVSs in the globus ...
Chen Yang, Shun-Nan Ge, Jia-Rui Zhang, Lei Chen, Zhi-Qiang Yan, Li-Jun Heng, Tian-Zhi Zhao, Wei-Xin Li, Dong Jia, Jun-Ling Zhu, Guo-Dong Gao   +10 more
doaj   +1 more source

Effects of 12-week Endurance Exercise on Dopamine Receptor Protein Expression in Hippocampus of Obese Rat [PDF]

운동과학, 2020
PURPOSE The purpose of this study was to investigate changes of body composition, D1 dopamine receptors (D1DR), and D2 dopamine receptors (D2DR) protein expression after 12 weeks of moderate-intensity treadmill exercise in hippocampus of high fat diet ...
Sungwook Kim, Kijin Kim
doaj   +1 more source

Methamphetamine increases locomotion and dopamine transporter activity in dopamine d5 receptor-deficient mice.

PLoS ONE, 2013
Dopamine regulates the psychomotor stimulant activities of amphetamine-like substances in the brain. The effects of dopamine are mediated through five known dopamine receptor subtypes in mammals.
Seiji Hayashizaki, Shinobu Hirai, Yumi Ito, Yoshiko Honda, Yosefu Arime, Ichiro Sora, Haruo Okado, Tohru Kodama, Masahiko Takada   +8 more
doaj   +1 more source

Dopamine Modulates Drosophila Gut Physiology, Providing New Insights for Future Gastrointestinal Pharmacotherapy

Biology, 2021
Dopamine has a variety of physiological roles in the gastrointestinal tract (GI) through binding to Drosophila dopamine D1-like receptors (DARs) and/or adrenergic receptors and has been confirmed as one of the enteric neurotransmitters.
Samar El Kholy, Kai Wang, Hesham R. El-Seedi, Yahya Al Naggar   +3 more
doaj   +1 more source

Dopamine D4 Receptors

Japanese Journal of Pharmacology, 2000
Initial investigations on dopamine D4 receptors generated much interest in the role of this receptor in schizophrenia and other aspects of human behavior, as well as new opportunities for novel therapeutics. However, attempts to treat patients suffering from schizophrenia with dopamine D4 agents have failed to yield satisfactory results so far.
M. Helmeste, Daiga, Wa Tang, Siu
openaire   +3 more sources

REDUCED EXPRESSION OF DOPAMINE D2-RECEPTORS ON PERIPHERAL BLOOD LYMPHOCYTES AS A MARKER FOR PROGRESSION OF SUBCORTICAL COGNITIVE IMPAIRMENTS

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Peripheral blood lymphocytes (PBL) express neurotransmitter and neuropeptide receptors. The dopamine receptors in PBL may reflect the status of homologous brain receptors.
O. A. Levada , I. V. Dobrodub, A. V. Trailin   +2 more
doaj   +1 more source