Results 1 to 10 of about 80,664 (276)

Pharmacological blockade of dopamine D1- or D2-receptor in the prefrontal cortex induces attentional impairment in the object-based attention test through different neuronal circuits in mice

Molecular Brain, 2021
Dopamine is a key neurotransmitter that regulates attention through dopamine D1 and D2-receptors in the prefrontal cortex (PFC). We previously developed an object-based attention test (OBAT) to evaluate attention in mice.
Bolati Wulaer, Kazuo Kunisawa, Moeka Tanabe, Aika Yanagawa, Kuniaki Saito, Akihiro Mouri, Toshitaka Nabeshima   +6 more
doaj   +1 more source

D2-Like Receptors Mediate Dopamine-Inhibited Insulin Secretion via Ion Channels in Rat Pancreatic β-Cells

Frontiers in Endocrinology, 2020
Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu, Lele Ren, Xiangqin Zhong, Yaqin Ding, Tao Liu, Tao Liu, Zhihong Liu, Zhihong Liu, Xiaohua Yang, Lijuan Cui, Lijuan Cui, Lijun Yang, Yanying Fan, Yunfeng Liu, Yi Zhang, Yi Zhang   +15 more
doaj   +1 more source

Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]

, 2020
Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S., Cardarelli, S., D'angelo, V., Fusco, F. R., Giorgi, M., Mercuri, N. B., Paldino, E., Sancesario, G., Sorge, R.   +8 more
core   +1 more source

Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity

Frontiers in Pharmacology, 2022
Cast immobilization causes sensory hypersensitivity, which is also a symptom of neuropathic pain and chronic pain. However, the mechanisms underlying immobilization-induced hypersensitivity remain unclear.
Yuki Kishikawa, Yuki Kishikawa, Yukie Kawahara, Yoshinori N. Ohnishi, Naoki Sotogaku, Tomoko Koeda, Hiroshi Kawahara, Akinori Nishi   +7 more
doaj   +1 more source

Dopamine, the dopamine D2 receptor and pituitary tumours [PDF]

Clinical Endocrinology, 1991
Dopamine plays an important role in the hypothalamic-pituitary axis where its major effects are to inhibit pituitary hormone secretion and cell division. Chronic dopamine deficiency has been postulated as a cause of pituitary tumour formation and several lines of evidence exist to suggest that a functional deficiency may develop as a result of ...
D F, Wood, J M, Johnston, D G, Johnston
openaire   +2 more sources

Cigarette Use and Striatal Dopamine D2/3 Receptors: Possible Role in the Link between Smoking and Nicotine Dependence. [PDF]

, 2016
BackgroundCigarette smoking induces dopamine release in the striatum, and smoking- or nicotine-induced ventral striatal dopamine release is correlated with nicotine dependence.
London, Edythe D, Mandelkern, Mark A, Okita, Kyoji   +2 more
core   +2 more sources

REDUCED EXPRESSION OF DOPAMINE D2-RECEPTORS ON PERIPHERAL BLOOD LYMPHOCYTES AS A MARKER FOR PROGRESSION OF SUBCORTICAL COGNITIVE IMPAIRMENTS

Zaporožskij Medicinskij Žurnal, 2013
Introduction. Peripheral blood lymphocytes (PBL) express neurotransmitter and neuropeptide receptors. The dopamine receptors in PBL may reflect the status of homologous brain receptors.
O. A. Levada , I. V. Dobrodub, A. V. Trailin   +2 more
doaj   +1 more source

Stress-induced reduction of dorsal striatal D2 dopamine receptors prevents retention of a newly acquired adaptive coping strategy [PDF]

, 2017
The inability to learn an adaptive coping strategy in a novel stressful condition leads to dysfunctional stress coping, a marker of mental disturbances.
Cabib, Simona, Campus, Paolo, Canterini, Sonia, Fiorenza, Maria Teresa, Orsini, Cristina, PUGLISI ALLEGRA, Stefano   +5 more
core   +1 more source

A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing

Molecules, 2017
Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein
Alexandra R. Vaughn, Michael James Davis, Raja K. Sivamani, Roslyn Rivkah Isseroff   +3 more
doaj   +1 more source

Gray-matter volume, midbrain dopamine D2/D3 receptors and drug craving in methamphetamine users. [PDF]

, 2015
Dysfunction of the mesocorticolimbic system has a critical role in clinical features of addiction. Despite evidence suggesting that midbrain dopamine receptors influence amphetamine-induced dopamine release and that dopamine is involved in ...
Dean, AC, Kohno, M, London, ED, Mandelkern, MA, Morales, AM, Robertson, CL   +5 more
core   +4 more sources