Results 1 to 10 of about 2,049 (91)

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling [PDF]

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +2 more sources

Spiperone Stimulates Regeneration in Pulmonary Endothelium Damaged by Cigarette Smoke and Lipopolysaccharide [PDF]

International Journal of COPD, 2021
Evgenii Skurikhin,1 Olga Pershina,1 Mariia Zhukova,1 Darius Widera,2 Edgar Pan,1 Angelina Pakhomova,1 Vyacheslav Krupin,1 Natalia Ermakova,1 Victoria Skurikhina,3 Lubov Sandrikina,1 Sergey Morozov,4 Aslan Kubatiev,4 Alexander Dygai1,4 1Laboratory of ...
Skurikhin E, Pershina O, Zhukova M, Widera D, Pan E, Pakhomova A, Krupin V, Ermakova N, Skurikhina V, Sandrikina L, Morozov S, Kubatiev A, Dygai A   +12 more
doaj   +2 more sources

Light Inhibits Lens-Induced Myopia through an Intensity-Dependent Dopaminergic Mechanism [PDF]

Ophthalmology Science
Purpose: Bright light exposure has been postulated to underlie the ability of time spent outdoors to prevent the development of myopia in humans. In support of this, bright light inhibits the development of form-deprivation myopia (FDM) in all species ...
Cindy Karouta, PhD, Kate Thomson, PhD, Ian Morgan, PhD, Regan Ashby, PhD   +3 more
doaj   +2 more sources

Unveiling and validating biomarkers related to the IL-10 family in chronic sinusitis with nasal polyps: insights from transcriptomics and single-cell RNA sequencing analysis [PDF]

Frontiers in Molecular Biosciences
IntroductionExtensive efforts have been made to explore members of the IL-10 family as potential therapeutic strategies for various diseases; however, their biological role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains underexplored ...
Xinghong Liu, Yi Peng, Ling Guo, Weilan Xiong, Weijiang Liao, Jiangang Fan   +5 more
doaj   +2 more sources

A novel role of protein tyrosine kinase2 in mediating chloride secretion in human airway epithelial cells. [PDF]

PLoS ONE, 2011
Ca(2+) activated Cl(-) channels (CaCC) are up-regulated in cystic fibrosis (CF) airway surface epithelia. The presence and functional properties of CaCC make it a possible therapeutic target to compensate for the deficiency of Cl(-) secretion in CF ...
Lihua Liang, Owen M Woodward, Zhaohui Chen, Robert Cotter, William B Guggino   +4 more
doaj   +1 more source

Modulation of bleomycin-induced lung fibrosis by pegylated hyaluronidase and dopamine receptor antagonist in mice. [PDF]

PLoS ONE, 2015
Hyaluronidases are groups of enzymes that degrade hyaluronic acid (HA). To stop enzymatic hydrolysis we modified testicular hyaluronidase (HYAL) by activated polyethylene oxide with the help of electron-beam synthesis.
Evgenii Germanovich Skurikhin, Olga Victorovna Pershina, Alena Mikhaylovna Reztsova, Natalia Nikolaevna Ermakova, Ekaterina Sergeevna Khmelevskaya, Vycheslav Andreevich Krupin, Inna Ernestovna Stepanova, Andrew Vladimirovich Artamonov, Andrew Alexandrovich Bekarev, Pavel Gennadjevich Madonov, Alexander Mikhaylovich Dygai   +10 more
doaj   +1 more source

Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function

Frontiers in Oncology, 2020
Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower ...
Marco Varalda, Marco Varalda, Annamaria Antona, Valentina Bettio, Valentina Bettio, Konkonika Roy, Ajay Vachamaram, Ajay Vachamaram, Vaibhav Yellenki, Alberto Massarotti, Gianluca Baldanzi, Gianluca Baldanzi, Daniela Capello, Daniela Capello   +13 more
doaj   +1 more source

Synthesis of novel 2-(piperazino-1-yl-alkyl)-1H-benzimidazole derivates and assessment of their interactions with the D2 dopamine receptor [PDF]

Journal of the Serbian Chemical Society, 2019
A total of 14 novel arylpiperazines were synthesized, and pharmacologically evaluated by measuring their affinities towards the D2 dopamine receptor (DRD2) in a [3H]spiperone competition assay.
Penjišević Jelena Z., Andrić Deana B., Šukalović Vladimir B., Roglić Goran M., Šoškić Vukić, Kostić-Rajačić Slađana V.   +5 more
doaj   +1 more source

Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors. [PDF]

PLoS ONE, 2016
Many G protein-coupled receptors have been shown to be sensitive to the presence of sodium ions (Na+). Using radioligand competition binding assays, we have examined and compared the effects of sodium ions on the binding affinities of a number of ...
Claire L Newton, Martyn D Wood, Philip G Strange   +2 more
doaj   +1 more source

Spatial reorganization of putaminal dopamine D2-like receptors in cranial and hand dystonia.

PLoS ONE, 2014
The putamen has a somatotopic organization of neurons identified by correspondence of firing rates with selected body part movements, as well as by complex, but organized, differential cortical projections onto putamen.
Kevin J Black, Abraham Z Snyder, Jonathan W Mink, Veeral N Tolia, Fredy J Revilla, Stephen M Moerlein, Joel S Perlmutter   +6 more
doaj   +1 more source