Results 31 to 40 of about 2,118 (153)
Molecular Therapy: Nucleic Acids, 2014 Well-differentiated human airway epithelia present formidable barriers to efficient siRNA delivery. We previously reported that treatment of airway epithelia with specific small molecules improves oligonucleotide uptake and facilitates RNAi responses ...
Sateesh Krishnamurthy +4 more
doaj +1 more source
Verification of the role of spiperone in the treatment of COPD through bioinformatics analysis
International Immunopharmacology, 2021 Aim of this study is investigates the influence of spiperone on hydrolase activity pathway in chronic obstructive pulmonary disease (COPD).Differentially expressed genes (DEGs) were calculated by the limma package from microarray data GSE20257, and analysed via gene set enrichment analysis (GSEA) for identifying COPD related pathways. The regulation of
Donglan, Zhu +4 more
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Frontiers in Neuroscience, 2015 In the Chagas disease vector, Rhodnius prolixus, two diuretic hormones act synergistically to dramatically increase fluid secretion by the Malpighian tubules (MTs) during the rapid diuresis that is initiated upon engorgement of vertebrate blood.
Jean-Paul V Paluzzi +10 more
doaj +1 more source
Aquaculture ReportsIn this study, we further investigate the hypothesis that serotonin plus spiperone (Ser+Spi) injection induces ovarian maturation and releases ovarian maturation inducing pheromones into the water, thereby stimulating neighboring untreated females ...
Isabel Quesada-Ávila +5 more
doaj +1 more source
Neurobiology of Disease, 2004 Different strategies have been worked out to promote survival of transplanted fetal ventral mesencephalic cells (VMCs) using trophic and nontrophic support. Olfactory ensheathing cells (OECs) express high level of growth factors including NGF, bFGF, GDNF,
A.K Agrawal +6 more
doaj +1 more source
An improved synthesis of (3-N-[11C]methyl)spiperone
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986 An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical
R F, Dannals +3 more
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EFFECTS OF SPIPERONE ON SELF‐STIMULATION AND OTHER ACTIVITIES OF THE MONGOLIAN GERBIL [PDF]
British Journal of Pharmacology, 1978 Self‐stimulation to lever pressing and capacitance probe touching was obtained in Mongolian gerbils (Meriones unguiculatus) from electrode placements within the medial forebrain bundle. Lever pressing was more sensitive to the decremental effects of a central depressant, pentobarbitone, than capacitance probe touching, suggesting its greater ...
N, Francis, E, Marley, J D, Stephenson
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Reviews in Aquaculture, Volume 18, Issue 2, March 2026.ABSTRACT Over the past four decades, substantial research has investigated the regulation of ovarian maturation and spawning in the black tiger prawn (Penaeus monodon). In this species, female reproduction is strongly suppressed by gonad‐inhibiting hormone (GIH) released from the eyestalk, making eyestalk ablation (ESA) the most widely adopted spawning‐
Gourab Chowdhury +4 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
In vitro Pharmacological Profile of 3-N-(2-Fluoroethyl)Spiperone [PDF]
Journal of Cerebral Blood Flow & Metabolism, 1990 The binding affinities of spiperone and 3-N-(2-fluoroethyl)spiperone (FESP) have been compared for several rodent brain receptor sites and for inhibition of monoamine release and uptake sites. FESP and spiperone have almost identical profiles, namely a high affinity for dopamine-D 2 and ...
A M, Goffinet, J, Leysen, D, Labar
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