Results 31 to 40 of about 3,002 (191)
Scientific Reports, 2017 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Sara Marsango +6 more
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[3H]-Spiperone Competition Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
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Verification of the role of spiperone in the treatment of COPD through bioinformatics analysis
International Immunopharmacology, 2021 Aim of this study is investigates the influence of spiperone on hydrolase activity pathway in chronic obstructive pulmonary disease (COPD).Differentially expressed genes (DEGs) were calculated by the limma package from microarray data GSE20257, and analysed via gene set enrichment analysis (GSEA) for identifying COPD related pathways. The regulation of
Donglan, Zhu +4 more
openaire +2 more sources
Journal of Toxicology, 2017 The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits.
José Abraham Márquez-Ramos +3 more
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Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice
Journal of Pharmacological Sciences, 2003 The present study examines the mechanism that underlies the ability of menthol (ME), a major constituent of peppermint oil, to promote mouse ambulation. We initially confirmed that bupropion (BUP), a dopamine (DA) uptake inhibitor, promotes ambulation in
Toyoshi Umezu, Masatoshi Morita
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Journal of Pharmacological Sciences, 2007 The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada +7 more
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An improved synthesis of (3-N-[11C]methyl)spiperone
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1986 An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical
R F, Dannals +3 more
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Molecular Therapy: Nucleic Acids, 2014 Well-differentiated human airway epithelia present formidable barriers to efficient siRNA delivery. We previously reported that treatment of airway epithelia with specific small molecules improves oligonucleotide uptake and facilitates RNAi responses ...
Sateesh Krishnamurthy +4 more
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Spiperone elicited currents in CHO cells transfected with wt-CFTR-GFP.
, 2013 (A): Representative currents attained before adding spiperone; (B): after adding spiperone; (C): in the presence of spiperone, adding CFTR-172 reduced the currents; (D): The summary data of spiperone effect in stimulating chloride current in CHO cells ...
Zhaohui Chen (348509) +4 more
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Frontiers in Neuroscience, 2015 In the Chagas disease vector, Rhodnius prolixus, two diuretic hormones act synergistically to dramatically increase fluid secretion by the Malpighian tubules (MTs) during the rapid diuresis that is initiated upon engorgement of vertebrate blood.
Jean-Paul V Paluzzi +10 more
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