Results 51 to 60 of about 3,002 (191)
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
, 2010 We recently investigated the binding properties of the antagonists [(3)H]-raclopride and [(3)H]-spiperone to intact Chinese hamster ovary cells expressing recombinant human D(2long)-dopamine receptors (CHO-D(2L) cells).
G. Vauquelin, J.P. De Backer, A. Packeu
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Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo +9 more
wiley +1 more source
PYK2 inhibitor tryphostin A-9 inhibits spiperone stimulated Ca2+ elevation and chloride secretion.
, 2013 A: Representative traces of spiperone stimulated transient increase in Ca2+ in IB3-1 cells (black trace), The elevation of Ca2+ was diminished when the cells pre-incubated with tryphostin A-9 (red trace).
Zhaohui Chen (348509) +4 more
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European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.This work introduces an efficient and gram‐scale microwave‐assisted (3+2) cycloaddition of nitrones with fluorinated allenylphosphonates, yielding diverse 4‐phosphinyl‐pyrrolidin‐3‐ones with exclusive 4,5‐trans diastereoselectivity in moderate to good yields.
Rayhane Hammami +6 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.We analyzed the current status of antipsychotics for Japanese forensic inpatients with schizophrenia spectrum disorders nationwide. Olanzapine was the most commonly prescribed antipsychotic, followed by clozapine. Clozapine was associated with longer hospitalization and a higher rate of seclusion experience.
Koji Takeda +9 more
wiley +1 more source
Aromatic linker variations in novel dopamine D2 and D3 receptor ligands
Archiv der Pharmazie, Volume 357, Issue 8, August 2024.Within the blueprint motifs of dopamine D2R/D3R ligands, the butyl (tetramethylene) linker was replaced by substituted benzyl or phenethyl linkers, maintaining high affinities at both receptor subtypes. Abstract Dopamine D2‐like receptors, especially D2 and D3 receptor subtypes, are important targets of antipsychotic agents.
Cristian Di Biase +4 more
wiley +1 more source
, 1988 The processes of receptor internalization and recycling have been well-documented for receptors for hormones, growth factors, lysosomal enzymes, and cellular substrates.
Michael E. Phelps +2 more
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Advanced Science, Volume 11, Issue 15, April 17, 2024.The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat +20 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 44, Issue 1, Page 17-28, March 2024.The structural equation model of the relationships between rejectionsensitivity (RS) and anxious‐depressive attack (ADA). RS contributes significantly to the onset of ADA. Abstract This paper aimed to find clues to treatment‐resistant depression (TRD) solutions.
Hisanobu Kaiya
wiley +1 more source