Results 71 to 80 of about 3,002 (191)

Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease

Journal of Neuroinflammation
Background Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is
Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek   +9 more
doaj   +1 more source

Decreased [¹⁸F]Spiperone Binding in Putamen in Idiopathic Focal Dystonia

, 1997
In this study we have investigated the pathophysiology of two idiopathic focal dystonias: hand cramp with excessive cocontractions of agonist and antagonist hand or forearm muscles during specific tasks, such as writing, and facial dystonia manifested by
Mikula K. Stambuk, Joel S. Perlmutter, Joanne Markham, Lori McGee-Minnich, Stephen M. Moerlein, Joseph Jankovic, Kevin J. Black   +6 more
core   +1 more source

Tyr-MIF-1 Attenuates Development of Tolerance to Spiperone-Induced Catalepsy in Rats

, 1993
Because the tripeptide MIF-1 (Pro-Leu-Gly-NH2) is known to attenuate the effects of neuroleptic-induced catalepsy as well as neuroleptic-induced proliferation of dopamine (DA) receptors, we studied the related naturally occurring peptide, Tyr-MIF-1 (Tyr ...
Kostrzewa, Richard M., Kastin, Abba J.
core   +1 more source

Effect of fluoxetine pretreatment on the neurochemical changes induced by amfonelic acid combined with spiperone in rats

, 1986
Combined treatment with amfonelic acid plus spiperone caused large increases in 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and a decrease in dopamine in rat striatum.
Harold D Snoddy, Ray W Fuller
core   +1 more source

In vivo Binding of Spiperone and N-Methylspiperone to Dopaminergic and Serotonergic Sites in the Rat Brain: Multiple Modeling and Implications for PET Scanning

, 1990
Equilibrium models are derived and applied to in vivo binding of spiperone in the rat brain. The models express the concentration of the ligand in the striatum and frontal cortex as a function of the accumulation in the cerebellum.
Jan F. van der Werf, Tonnie Wiegman, Willem Vaalburg, Jacobus A. A. Swart, Jakob Korf, Anne M. J. Paans   +5 more
core   +1 more source

Effect of a corn diet during development on [3H]-spiperone binding in the brain of rats at the perinatal stage

, 1995
A model of undernutrition based on feeding with a corn-diet (tryptophan deficient) was used to study maturation and physiology of the rat brain 5-HTergic system.
Feria-Velasco, A., Beas-Zárate, Carlos, Del Angel Meza, A.R., Ortuno-Sahagun, D.   +3 more
core   +1 more source

Relationship Between Dopamine Receptor Occupation by Spiperone and Acetylcholine Levels in the Rat Striatum After Long‐Term Haloperidol Treatment Depends on Dopamine Innervation

, 1987
The effect of chronic neuroleptic treatment on the relationship between the blockade of dopamine (DA) receptors by the neuroleptic drug spiperone and the decline in acetylcholine (ACh) levels was determined in the rat striatum in vivo.
Sebens, Jantiena B., KORF, J, Jakob Korf, SEBENS, JB, Korf, Jakob, Jantiena B. Sebens   +5 more
core   +1 more source

Potentiation of Spiperone-Induced Oral Activity in Rats After Neonatal 6-Hydroxydopamine

, 1991
The influence of central dopaminergic fibers on drug-induced oral activity in rats has not been well studied. Rats were treated 3 days after birth with bilateral intracerebroventricular 6-hydroxydopamine (6-OHDA; 134 ωg total, base form) to destroy ...
Hamdi, Anwar, Kostrzewa, Richard M.
core   +1 more source

Central administration of dopamine D3 receptor antisense to rat: effects on locomotion, dopamine release and [H-3]spiperone binding

, 1998
A 15-mer, all-phosphorothioate-modified antisense oligodeoxynucleotide (ASO) targeted against rat dopamine D3 receptor mRNA (4 mu M, 5 days) significantly reduced (28%) the amount of binding sites labelled with [H-3]spiperone in monolayer cultured ...
Eriksson, E, Ekman, A, Heilig, M, Dijkstra, D, Nissbrandt, H   +4 more
core   +1 more source

3-(2'-[¹⁸F]Fluoroethyl)Spiperone: In vivo Biochemical and Kinetic Characterization in Rodents, Nonhuman Primates, and Humans

, 1989
3-(2'-[18F]fluoroethyl)spiperone (FESP), a recently developed dopamine D2-receptor binding radiopharmaceutical, was used for dynamic characterization of dopamine-receptor binding in Macaca nemestrina monkeys and humans with positron emission tomography ...
Randy E. Keen, Michael E. Phelps, Jorge R. Barrio, John M. Hoffman, Charna H. K. Nissenson, Nagichettiar Satyamurthy, Sung-Cheng Huang, Robert F. Ackermann, Mark M. Bahn, John C. Mazziotta   +9 more
core   +1 more source