Results 91 to 100 of about 2,118 (153)

Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria. [PDF]

RSC Med Chem
Chen LH, Lin MY, Lin HC, Yang FW, Liao HW, Shiau CW, Chiu HC, Su JC.   +7 more
europepmc   +1 more source

Association between polypharmacy and the long-term prescription of hypnotics in Japan: a retrospective cross-sectional study. [PDF]

Front Psychiatry
Komatsu M, Takeshima M, Yoshizawa K, Ogasawara M, Kudo M, Miyakoshi E, Itoh Y, Shibata N, Ayabe N, Mishima K.   +9 more
europepmc   +1 more source

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Spiperone: Tritium labelling at high specific activity

Applied Radiation and Isotopes, 2019
An efficient method is described to tritiate spiperone at high specific activity.
Crist Filer
exaly   +3 more sources

Taurine interferes with spiperone binding in the striatum

Neuroscience, 1986
The effects of taurine and its structural analogues and two new anticonvulsant derivatives, taltrimide and MY-103, on the function of brain dopaminergic systems were studied by assessing their interference with the binding of [3H]spiperone to synaptic membranes isolated from rat striata. Two populations of binding sites were detected.
P, Kontro, S S, Oja
openaire   +2 more sources

Methodology of 3H-spiperone binding to lymphocytes

Journal of Psychiatric Research, 1990
Alterations in lymphocyte binding capacity for the dopamine antagonist 3H-spiperone may be of great interest in psychiatric and neurological disorders: an increase in capacity noted in lymphocytes of schizophrenic patients and their families may well turn out to be a phenotypic vulnerability marker. Since the 3H-spiperone binding assay with lymphocytes
B, Bondy, M, Ackenheil, R R, Engel
openaire   +2 more sources

Uptake of 3H-spiperone by lymphocytes in schizophrenia

Journal of Psychiatric Research, 1989
Uptake of 3H-spiperone into lymphocytes obtained from control subjects (N = 22), chronic schizophrenics (N = 20), relatives with psychiatric disorder (N = 11) and unaffected relatives (N = 17) was studied. No differences were observed in spiperone uptake among any of the groups examined.
S, Itzchaky, B, Lerer, R P, Ebstein
openaire   +2 more sources

Effect of Chronic Sulpiride on Striatal Spiperone Binding

International Pharmacopsychiatry, 2017
Increased ^3 H-spiperone binding after chronic neuroleptic treatment has been proposed as a molecular model of tardive dyskinesia. Sulpiride has been claimed to be an atypical neuroleptic that might not produce tardive dyskinesia. The effect of chronic sulpiride was, therefore, compared to that of chronic haloperidol on striatal ^3 H-spiperone binding.
J, Bannet, S, Gillis, R P, Ebstein, R H, Belmaker   +3 more
openaire   +2 more sources

A study of the kinetics of the interaction of spiperone with binding sites on human mononuclear cells: existence of a heterogeneous population of spiperone binding sites

Journal of Neuroimmunology, 1992
The kinetics and equilibrium of the interaction of [3H]spiperone with binding sites on human mononuclear cells were studied using a competitive displacement of spiperone by ketanserin, sulpiride, haloperidol, (+)- and (-)-butaclamol. [3H]Spiperone binding sites on human mononuclear cells were shown to be not of the D2, but most probably of the 5-HT2 ...
S V, Zaitsev, A A, Koshkin, I I, Izumrudova, S D, Varfolomeev   +3 more
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Biochemical Properties of Spiperone Binding to Rat Brain Membranes

Pharmacology, 2008
The biochemical properties of 3H-spiperone binding in vitro were studied systematically using a crude membrane homogenate of rat corpus striatum and separation by filtration. Scatchard analysis revealed a single high affinity site with a K_D of 0.14 nM and B_max of 26 fmol/mg of tissue.
R H, Sundermann, G F, Wooten
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[3H]spiperone binding in the nigrostriatal system in human brain

European Journal of Pharmacology, 1984
The characteristics of [3H]spiperone binding in human brain were compared in three areas of the nigrostriatal pathway: areas containing the nerve terminals (caudate nucleus, putamen and pallidum); the area containing the cell bodies (substantia nigra pars compacta); the area containing the dendrites (pars reticulata).
M, Ruberg, B, Bokobza, F, Javoy-Agid, J C, Montfort, Y, Agid   +4 more
openaire   +2 more sources