Results 111 to 120 of about 2,118 (153)
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Chronic proglumide increases [3H]spiperone binding in the rat brain
European Journal of Pharmacology, 1985The cholecystokinin (CCK) antagonist, proglumide, administered chronically (41.0-53.5 mg/kg per day, 14 days) to rats via osmotic mini-pumps, produced a significant 13% increase in the number of [3H]spiperone labeled binding sites (Bmax) in the striatum. There was no associated change in the affinity (Kd) of [3H]spiperone for the striatal binding sites.
A J, Bean, W J, Baldy, G E, Martin
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Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 19863-N-([18F]fluoroalkyl)spiperone derivatives (2,3) can be prepared by N-alkylation of spiperone (1) with fluoroalkyl halides. The fluoroalkylating species 2-[18F]fluoroethyl bromide (7), 3-[18F]fluoropropyl bromide (8) and 4-[18F]fluorobutyl bromide (9) were prepared by [18F]fluoride ion displacement of the corresponding trifluoromethanesulfonates ...
D Y, Chi +4 more
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[3H] Spiperone Binding to Lymphocytes in Psychiatric Disorders
1990There is ample evidence indicating that the central nervous system and the immune system are functionally linked. The exact mode of neural — immune interaction is still not certain, however the presence of specific neurotransmitter receptors on these cells appears to be important in mediating an intracellular event which could then lead to alterations ...
B. Bondy, B. Peuker, M. Ackenheil
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The effects of exercise training on [3H]-spiperone binding in rat striatum
Pharmacology Biochemistry and Behavior, 1984Thirty male Sprague-Dawley rats 100 days of age were divided into three groups: interval trained, endurance trained, and pair-weighted controls. Both trained groups ran up to one hour per day, 6 days per week for 12 weeks. The interval trained group ran up to 20 repeat intervals at 54 meters per minute for 30 seconds, while the endurance trained group ...
P E, Gilliam +5 more
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Comparison of 3H-spiperone binding in caudate nuclei of rabbits and rats
Pharmacology Biochemistry and Behavior, 19873H-Spiperone binding and inhibition by competing ligands were studied in caudate nucleus homogenates from Sprague-Dawley rats and New Zealand albino rabbits. 3H-Spiperone binding sites were very similar in the two species and had pharmacological profiles characteristic of D2-dopamine receptors, in accordance with previous reports.
L L, Hernandez, D A, Powell
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Haloperidol and spiperone potentiate murine splenic B cell proliferation
Immunopharmacology, 1996The neuroleptics haloperidol and spiperone potentiated anti-mu induced murine B-lymphocyte proliferation in vitro and lowered the threshold of anti-mu antibody needed to trigger proliferation. Because haloperidol and spiperone are best known for actions at D2, 5HT2, alpha 1 and sigma (sigma) receptors, a series of agonists and antagonists of these ...
Y, Liu, S A, Wolfe
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3H-Spiperone binding to peripheral mononuclear cells in psychiatric in-patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19961. There is an ongoing controversy, if increased binding of 3H-spiperone to lymphocytes might discriminate between schizophrenia and other psychiatric diseases or even be a genetic vulnerability marker for schizophrenia, or predict the response to neuroleptic treatment. 2.
N, Wodarz, J, Fritze, P, Riederer
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Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis
Annals of Neurology, 1986AbstractLevels of dopamine and serotonin, and of their precursors and metabolites, were measured in the nucleus basalis of Meynert (nbM) of patients with Alzheimer's disease and control patients. [3H]Spiperone binding to membrane homogenates of the nbM, indicative of both dopaminergic and serotonergic receptors, was also measured. The nbM from patients
D L, Sparks +2 more
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3H-spiperone binding capacity in mononuclear cells: A family study
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19931. A family study was carried out using a putative biological vulnerability trait in families of schizophrenics and schizoaffective indexprobands to investigate, if the clinical phenotype and a biological marker for schizophrenia are cosegregating within families. 2.
B, Bondy +7 more
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The effect of cholecystokinin octapeptide on rat striatal 3H spiperone binding
Biochemical Pharmacology, 1985In the rat striatum sulphated CCK8 has no significant effect on equilibrium binding of 3H-spiperone but has a considerable, although transient, effect under non-equilibrium conditions. Under non-equilibrium conditions (during the association phase of ligand binding) and at high ligand concentrations (1 nM), CCK8 displaces specific binding and at low ...
C, O'Shaughnessy +2 more
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