Results 41 to 50 of about 3,002 (191)

CuZn-superoxide dismutase transgenic mice: no effect on longevity, locomotor activity and 3H-mazindol and 3H-spiperone binding over 19 months

open access: yes, 2000
This study was designed to determine whether CuZn-superoxide dismutase (SOD) is neuroprotective against aging in the nigrostriatal tract. Twenty-four male mice transgenic for human CuZnSOD, resulting in overexpression of the cytosolic enzyme, were ...
Glover, V.   +3 more
core   +1 more source

Haloperidol, spiperone, pimozide and aripiprazole reduce intracellular dopamine content in PC12 cells and rat mesencephalic cultures: Implication of inhibition of vesicular transport. [PDF]

open access: yes, 2010
Accumulating evidence suggests that antipsychotics affect dopamine release from dopaminergic neurons, but the precise mechanisms are not fully understood.
Sawada, Hideyuki   +6 more
core   +1 more source

Serotonin plus spiperone induce ovarian maturation, spawning and potential release of ovarian maturation inducing pheromones in the Pacific white shrimp Litopenaeus vannamei (Penaeidae)

open access: yesAquaculture Reports
In this study, we further investigate the hypothesis that serotonin plus spiperone (Ser+Spi) injection induces ovarian maturation and releases ovarian maturation inducing pheromones into the water, thereby stimulating neighboring untreated females ...
Isabel Quesada-Ávila   +5 more
doaj   +1 more source

Olfactory ensheathing cell transplantation restores functional deficits in rat model of Parkinson's disease: a cotransplantation approach with fetal ventral mesencephalic cells

open access: yesNeurobiology of Disease, 2004
Different strategies have been worked out to promote survival of transplanted fetal ventral mesencephalic cells (VMCs) using trophic and nontrophic support. Olfactory ensheathing cells (OECs) express high level of growth factors including NGF, bFGF, GDNF,
A.K Agrawal   +6 more
doaj   +1 more source

Definition of the In-vivo Binding of [3H]Spiperone in Rat Brain Using Substituted Benzamide Drugs

open access: yes, 1989
The ability of some substituted benzamide drugs to define in-vivo the binding of [3H]spiperone to brain dopamine receptors in rats was assessed using behaviourally effective doses in comparison with haloperidol. As judged using haloperidol, [3H]spiperone
C Reavill   +3 more
core   +1 more source

Effects of SCH23390 and spiperone administered into medial striatum and intermediate medial mesopallium on rewarding effects of morphine in day-old chicks

open access: yes, 2010
.In the avian forebrain, the medial striatum and the intermediate medial mesopallium are thought to be important structures for associative learning in chicks, where the role of dopaminergic systems in learning processes has been verified in various ...
Sui, Nan, He, Xingu, Nan Sui, Xiao, Lin
core   +2 more sources

Molecular and Endocrine Regulation of Ovarian Maturation in the Black Tiger Prawn (Penaeus monodon) and Associated Challenges in Its Aquaculture

open access: yesReviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT Over the past four decades, substantial research has investigated the regulation of ovarian maturation and spawning in the black tiger prawn (Penaeus monodon). In this species, female reproduction is strongly suppressed by gonad‐inhibiting hormone (GIH) released from the eyestalk, making eyestalk ablation (ESA) the most widely adopted spawning‐
Gourab Chowdhury   +4 more
wiley   +1 more source

EFFECTS OF SPIPERONE ON SELF‐STIMULATION AND OTHER ACTIVITIES OF THE MONGOLIAN GERBIL [PDF]

open access: yesBritish Journal of Pharmacology, 1978
Self‐stimulation to lever pressing and capacitance probe touching was obtained in Mongolian gerbils (Meriones unguiculatus) from electrode placements within the medial forebrain bundle. Lever pressing was more sensitive to the decremental effects of a central depressant, pentobarbitone, than capacitance probe touching, suggesting its greater ...
N, Francis, E, Marley, J D, Stephenson
openaire   +2 more sources

[125I] Spiperone is not a useful ligand for studying the CHAPS solubilized dopamine D-2 receptor from rat striatum

open access: yes, 1986
The interaction of [125I]spiperone and [3H]spiperone with CHAPS solubilized preparations of rat striatal tissue has been compared. Only about 15% of [125I]spiperone binding was displaced by sulpiride compared with about 67% of [3H]spiperone binding.
C D Marsden, G J Kilpatrick, P Jenner
core   +1 more source

Spiperone stimulated chloride current by whole cell voltage clamp recording in IB3-1 cells transfected with wt-CFTR-GFP.

open access: yes, 2013
(A): Representative currents elicited by 15 mV steps from -100 mV to 125 mV. (B): Currents after addition of spiperone; (C): Currents after addition of CFTR172; (D): Currents after addition of 4,4-Diisothiocyanatostilbene-2,2′-disulfonic acid (DIDS) (E):
Zhaohui Chen (348509)   +4 more
core   +1 more source

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