Results 41 to 50 of about 2,118 (153)

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.
This work introduces an efficient and gram‐scale microwave‐assisted (3+2) cycloaddition of nitrones with fluorinated allenylphosphonates, yielding diverse 4‐phosphinyl‐pyrrolidin‐3‐ones with exclusive 4,5‐trans diastereoselectivity in moderate to good yields.
Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐François Poisson, Tahar Ayad, Benjamin Darses   +6 more
wiley   +1 more source

Current status and features of antipsychotic prescriptions in Japanese forensic psychiatric wards based on a forensic inpatient database

Neuropsychopharmacology Reports, Volume 45, Issue 1, March 2025.
We analyzed the current status of antipsychotics for Japanese forensic inpatients with schizophrenia spectrum disorders nationwide. Olanzapine was the most commonly prescribed antipsychotic, followed by clozapine. Clozapine was associated with longer hospitalization and a higher rate of seclusion experience.
Koji Takeda, Hiroko Kashiwagi, Keisuke Takanobu, Ryotaro Kubota, Ryo Naoe, Yuji Yamada, Junko Koike, Toshiaki Kono, Yuki Kako, Naotsugu Hirabayasi   +9 more
wiley   +1 more source

Aromatic linker variations in novel dopamine D2 and D3 receptor ligands

Archiv der Pharmazie, Volume 357, Issue 8, August 2024.
Within the blueprint motifs of dopamine D2R/D3R ligands, the butyl (tetramethylene) linker was replaced by substituted benzyl or phenethyl linkers, maintaining high affinities at both receptor subtypes. Abstract Dopamine D2‐like receptors, especially D2 and D3 receptor subtypes, are important targets of antipsychotic agents.
Cristian Di Biase, Luisa Leitzbach, Annika Frank, Aleksandra Zivkovic, Holger Stark   +4 more
wiley   +1 more source

Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine‐Independent and Chronic Itch

Advanced Science, Volume 11, Issue 15, April 17, 2024.
The potassium channel Slack is highly expressed in sensory neurons that sense itch. In this study, several new compounds that activate Slack are developed. It is found that the lead molecule, compound 6, effectively inhibits scratching elicited by multiple pruritogens in mice establishing Slack activation as a novel pharmacological strategy for the ...
Annika Balzulat, W. Felix Zhu, Cathrin Flauaus, Victor Hernandez‐Olmos, Jan Heering, Sunesh Sethumadhavan, Mariam Dubiel, Annika Frank, Amelie Menge, Maureen Hebchen, Katharina Metzner, Ruirui Lu, Robert Lukowski, Peter Ruth, Stefan Knapp, Susanne Müller, Dieter Steinhilber, Inga Hänelt, Holger Stark, Ewgenij Proschak, Achim Schmidtko   +20 more
wiley   +1 more source

Anxious‐depressive attack and rejection sensitivity—Toward a new approach to treatment‐resistant depression

Neuropsychopharmacology Reports, Volume 44, Issue 1, Page 17-28, March 2024.
The structural equation model of the relationships between rejectionsensitivity (RS) and anxious‐depressive attack (ADA). RS contributes significantly to the onset of ADA. Abstract This paper aimed to find clues to treatment‐resistant depression (TRD) solutions.
Hisanobu Kaiya
wiley   +1 more source

Induction of ovarian growth in Aegla platensis (Crustacea, Aeglidae) by means of neuroregulators incorporated to food

Revista de Biología Tropical, 2008
The freshwater crab Aegla platensis was used as a model to induce ovarian growth by adding different neuroregulators to a pellet food formulation. Added compounds were the dopaminergic inhibitor spiperone or the enkephalinergic inhibitor naloxone, both ...
Alejandra V Cahansky, Bibiana Kaiser Dutra, Daniela da Silva Castiglioni, Guendalina Turcato Oliveira, Georgina Bond Buckup, Enrique M Rodríguez   +5 more
doaj  

Effects of chronic haloperidol treatment on the expression of fear memory and fear memory extinction in the cued fear‐conditioned rats

Neuropsychopharmacology Reports, Volume 44, Issue 1, Page 197-205, March 2024.
Chronic haloperidol impacts fear memory differently than single doses. Our study unveils how chronic D2R antagonist treatment alters fear memory expression and extinction in rats, offering crucial insights into potential therapeutic approaches for fear memory disorders.
Kosuke Enomoto, Kazuro Shibata, Hiroyuki Muraoka, Masahiko Kawano, Ken Inada, Jun Ishigooka, Katsuji Nishimura, Hidehiro Oshibuchi   +7 more
wiley   +1 more source

Fluorescent Tools for the Imaging of Dopamine D2‐Like Receptors**

ChemBioChem, Volume 25, Issue 2, January 15, 2024.
In this study, we have identified UR‐MN212 (20), a spiperone‐based fluorescent ligand bearing a 5‐TAMRA dye, as suitable for fluorescence microscopy at the D2R. The binding affinity in the single‐digit nanomolar range could be determined in radioligand competition binding and molecular brightness studies at D2‐like receptors.
Martin Nagl, Denise Mönnich, Niklas Rosier, Hannes Schihada, Alexei Sirbu, Nergis Konar, Irene Reyes‐Resina, Gemma Navarro, Rafael Franco, Peter Kolb, Paolo Annibale, Steffen Pockes   +11 more
wiley   +1 more source

Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease

Journal of Neuroinflammation
Background Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is
Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek   +9 more
doaj   +1 more source