Spiperone: evidence for uptake into secretory granules. [PDF]
Proceedings of the National Academy of Sciences, 1984 Spiperone, a dopamine antagonist widely used as a specific ligand for dopamine and serotonin receptors, is actively accumulated into the F4C1 strain of rat pituitary tumor cells. The accumulation of 10 nM [3H]spiperone was linear for 3 min and reached a steady state after 10 min.
P S, Dannies +3 more
openaire +2 more sources
Myopia control in Mendelian forms of myopia
Ophthalmic and Physiological Optics, Volume 43, Issue 3, Page 494-504, May 2023., 2023 Abstract Purpose To study the effectiveness of high‐dose atropine for reducing eye growth in Mendelian myopia in children and mice. Methods We studied the effect of high‐dose atropine in children with progressive myopia with and without a monogenetic cause. Children were matched for age and axial length (AL) in their first year of treatment.
Emilie van der Sande +11 more
wiley +1 more source
Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?
Clinical &Translational Immunology, Volume 12, Issue 10, 2023., 2023 The present review aims to collect and critically summarise available evidence regarding the immune effects of dopamine and their mimics and to put dopaminergic agents used as antiparkinsonian drugs in the perspective of current knowledge about the involvement of immunity and inflammation in Parkinson's disease (PD).
Alessia Furgiuele +4 more
wiley +1 more source
Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. [PDF]
PLoS ONE, 2014 Several lines of evidence demonstrate that oxidative stress is involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Potent antioxidants may therefore be effective in the treatment of such diseases.
Haruki Odaka +7 more
doaj +1 more source
Inhibition of Cutaneous Contact Hypersensitivity in the Mouse with Systemic or Topical Spiperone: Topical Application of Spiperone Produces Local Immunosuppression Without Inducing Systemic Neuroleptic Effects [PDF]
, 1992 We tested the ability of the neuroleptic agent spiperone (8-[3-{p-fluorobenzoyl}propyl]-l-phenyl-l,3,8-triazaspiro-[4.5]decan-4-one) to influence the tissue swelling and leukocyte infiltration associated with T-cell-dependent immune responses, i.e ...
Chandrasekar, Akila +9 more
core +1 more source
Motions around conserved helical weak spots facilitate GPCR activation
Proteins: Structure, Function, and Bioinformatics, Volume 89, Issue 11, Page 1577-1586, November 2021., 2021 Abstract G protein‐coupled receptors (GPCRs) participate in most physiological processes and are important drug targets in many therapeutic areas. Recently, many GPCR X‐ray structures became available, facilitating detailed studies of their sequence‐structure‐mobility‐function relations.
Janne M. Bibbe, Gert Vriend
wiley +1 more source
Long term effects of pergolide and (-)-deprenyl on 3H-mazindol and 3H-spiperone binding in rat brain
, 1999 The effects of long-term administration of the putative neuroprotective agents pergolide and (−)-deprenyl was assessed by studying 3H-mazindol and 3H-spiperone binding at 12 and 20 months in the major dopamine brain regions. Male Wistar rats were treated
Glover, V. +3 more
core +2 more sources
Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship. [PDF]
PLoS ONE, 2011 BACKGROUND: Three dopamine receptor genes have been identified that are highly conserved among arthropod species. One of these genes, referred to in honey bees as Amdop2, shows a close phylogenetic relationship to the a-adrenergic-like octopamine ...
Kyle T Beggs +2 more
doaj +1 more source
[3H]-Spiperone Saturation Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +1 more source