Results 21 to 30 of about 2,118 (153)
Dopaminergic regulation of inflammation and immunity in Parkinson's disease: friend or foe?
Clinical &Translational Immunology, Volume 12, Issue 10, 2023., 2023 The present review aims to collect and critically summarise available evidence regarding the immune effects of dopamine and their mimics and to put dopaminergic agents used as antiparkinsonian drugs in the perspective of current knowledge about the involvement of immunity and inflammation in Parkinson's disease (PD).
Alessia Furgiuele +4 more
wiley +1 more source
Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity. [PDF]
PLoS ONE, 2014 Several lines of evidence demonstrate that oxidative stress is involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Potent antioxidants may therefore be effective in the treatment of such diseases.
Haruki Odaka +7 more
doaj +1 more source
Motions around conserved helical weak spots facilitate GPCR activation
Proteins: Structure, Function, and Bioinformatics, Volume 89, Issue 11, Page 1577-1586, November 2021., 2021 Abstract G protein‐coupled receptors (GPCRs) participate in most physiological processes and are important drug targets in many therapeutic areas. Recently, many GPCR X‐ray structures became available, facilitating detailed studies of their sequence‐structure‐mobility‐function relations.
Janne M. Bibbe, Gert Vriend
wiley +1 more source
Honey bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship. [PDF]
PLoS ONE, 2011 BACKGROUND: Three dopamine receptor genes have been identified that are highly conserved among arthropod species. One of these genes, referred to in honey bees as Amdop2, shows a close phylogenetic relationship to the a-adrenergic-like octopamine ...
Kyle T Beggs +2 more
doaj +1 more source
[3H]-Spiperone Saturation Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +1 more source
Scientific Reports, 2017 The dopamine D3 receptor (D3R) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a ...
Sara Marsango +6 more
doaj +1 more source
[3H]-Spiperone Competition Binding to Dopamine D2, D3 and D4 Receptors
Bio-Protocol, 2013 This protocol is intended for use in 96 well plates (1,200 μl wells) but it can similarly be applied to standard test tubes (Levant, 2007). D2, D3, and D4 dopamine receptors are members of the D2-like class of dopamine receptors.
Jan-Peter Wieringen, Martin Michel
doaj +1 more source
Journal of Toxicology, 2017 The herbicide atrazine (ATR) has a potential toxic effect on the neuronal circuits of the brain, specifically on two major dopaminergic pathways: the nigrostriatal and mesolimbic circuits.
José Abraham Márquez-Ramos +3 more
doaj +1 more source
Evidence for the Involvement of Dopamine in Ambulation Promoted by Menthol in Mice
Journal of Pharmacological Sciences, 2003 The present study examines the mechanism that underlies the ability of menthol (ME), a major constituent of peppermint oil, to promote mouse ambulation. We initially confirmed that bupropion (BUP), a dopamine (DA) uptake inhibitor, promotes ambulation in
Toyoshi Umezu, Masatoshi Morita
doaj +1 more source
Journal of Pharmacological Sciences, 2007 The aim of the present study was to elucidate the pathogenic role of endogenous 5-HT in pancreatitis. Injections of cerulein at hourly intervals caused edematous pancreatitis in mice characterized by hyperenzymemia and histological alterations. While the
Kentaro Hamada +7 more
doaj +1 more source