D2 dopamine receptor gene and obesity [PDF]
International Journal of Eating Disorders, 1994 The prevalence of Taql A D2 dopamine receptor (DRD2) alleles was determined in 73 obese women and men. In this sample with a mean body mass index of 35.1, the A1 (minor) allele of the DRD2 gene was present in 45.2% of these nonalcohol, nondrug abusing subjects. The DRD2 A1 allele was not associated with a number of cardiovascular risk factors examined,
E P, Noble +8 more
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Role of dopamine D1-like receptors in methamphetamine locomotor responses of D2 receptor knockout mice [PDF]
, 2008 Behavioral sensitization to psychostimulants manifests as an increased locomotor response with repeated administration. Dopamine systems are accepted to play a fundamental role in sensitization, but the role of specific dopamine receptor subtypes has not
Atkins +47 more
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Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.
PLoS ONE, 2013 Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine receptors and inputs of aversion coming from neurons containing the D2-like family of dopamine
Gemma Navarro +13 more
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Dopamine receptors in a songbird brain. [PDF]
, 2010 Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior.
Jarvis, ED, Kubikova, L, Wada, K
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Desensitized D2 autoreceptors are resistant to trafficking
Scientific Reports, 2017 Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons.
Brooks G. Robinson +7 more
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Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans. [PDF]
PLoS ONE, 2014 Caenorhabditis elegans is a useful model to study the neuronal or molecular basis for behavioral choice, a specific form of decision-making. Although it has been implied that both D1-like and D2-like dopamine receptors may contribute to the control of ...
Daoyong Wang +4 more
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Tonic inhibition of accumbal spiny neurons by extrasynaptic 4 GABAA receptors modulates the actions of psychostimulants [PDF]
, 2014 Within the nucleus accumbens (NAc), synaptic GABAA receptors (GABAARs) mediate phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to cocaine.
Belelli, D +8 more
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Antisera specific for D2 dopamine receptors [PDF]
Biochemical Journal, 1993 Antisera have been raised against two peptides from the sequence of D2 dopamine receptors: peptide 1 from the predicted second extracellular loop and peptide 2 from the predicted third intracellular loop. The antisera recognize specifically a 95 kDa band in Western blots of several bovine brain regions, which corresponds to the denatured D2 dopamine ...
P L, Chazot, A J, Doherty, P G, Strange
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Probing the role of the cation–π interaction in the binding sites of GPCRs using unnatural amino acids [PDF]
, 2009 We describe a general application of the nonsense suppression methodology for unnatural amino acid incorporation to probe drug–receptor interactions in functional G protein-coupled receptors (GPCRs), evaluating the binding sites of both the M2 muscarinic
Ballesteros +31 more
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Role of D1/D2 dopamin receptors antagonist perphenazine in morphine analgesia and tolerance in rats
Biomolecules & Biomedicine, 2013 While opioid receptors have been implicated in the development of tolerance, the subsequent mechanisms involved in these phenomena have not been completely understood.
Ercan Ozdemir +2 more
doaj +1 more source