Results 21 to 30 of about 80,664 (276)

Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. [PDF]

PLoS ONE, 2010
Variation of the gene coding for D2 receptors (DRD2) has been associated with risk for schizophrenia and with working memory deficits. A functional intronic SNP (rs1076560) predicts relative expression of the two D2 receptors isoforms, D2S (mainly pre ...
Alessandro Bertolino, Paolo Taurisano, Nicola Marco Pisciotta, Giuseppe Blasi, Leonardo Fazio, Raffaella Romano, Barbara Gelao, Luciana Lo Bianco, Madia Lozupone, Annabella Di Giorgio, Grazia Caforio, Fabio Sambataro, Artor Niccoli-Asabella, Audrey Papp, Gianluca Ursini, Lorenzo Sinibaldi, Teresa Popolizio, Wolfgang Sadee, Giuseppe Rubini   +18 more
doaj   +1 more source

Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response - a double-blind PET study in schizophrenia [PDF]

, 2007
Blockade of dopamine D2 receptors remains a common feature of all antipsychotics. It has been hypothesized that the extrastriatal (cortical, thalamic) dopamine D2 receptors may be more critical to antipsychotic response than the striatal dopamine D2 ...
AA Lammertsma, AL Nordstrom, Alan A Wilson, B Efron, C Studholme, D Joel, David Mamo, DV Sheehan, GE Alexander, GJ Mogenson, GM Simpson, H Hall, H Olsson, H Olsson, Irina Vitcu, J Arnt, J Arnt, JD Bremner, L de Haan, L Farde, L Farde, LS Pilowsky, M Talvik, Nathalie Ginovart, O Agid, Ofer Agid, P Voorn, R Kessler, RB Chronister, RC Roberts, RM Kessler, Robert B Zipursky, S Houle, S Kapur, S Kapur, S Kapur, S Kapur, S Kapur, S Leucht, S Nyberg, S Nyberg, Shitij Kapur, SN Haber, SR Kay, TR Barnes, V Bigliani, W Guy, X Xiberas, X Xiberas   +48 more
core   +1 more source

Effects on turning of microinjections into basal ganglia of D1 and D2 dopamine receptors agonists and the cannabinoid CB1 antagonist SR141716A in a rat Parkinson's model

Neurobiology of Disease, 2004
Brain cannabinoid CB1 receptors are expressed in neural areas that contribute to movement such as basal ganglia, where they co-localize with dopamine D1 and D2 receptors.
Fadwa El Banoua, Isabel Caraballo, Juan A Flores, Beatriz Galan-Rodriguez, Emilio Fernandez-Espejo   +4 more
doaj   +1 more source

Dopamine D2 receptors and the circadian clock reciprocally mediate antipsychotic drug-induced metabolic disturbances

npj Schizophrenia, 2017
Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes.
Zachary Freyberg, Michael J. McCarthy
doaj   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Proteins Interacting With the Third Cytoplasmic Loop of Dopamine D2 and D3 Receptors

Journal of Pharmacological Sciences, 2010
Among the various dopamine receptors, D2-like receptors (D2R, D3R, and D4R) are characterized by a large third cytoplasmic loop, a short carboxyl-terminal tail, and the ability to activate inhibitory G proteins.
Norifumi Shioda, Yusuke Takeuchi, Kohji Fukunaga   +2 more
doaj   +1 more source

Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse. [PDF]

, 2016
Mother-infant interactions are known to be associated with the psychological well-being of an individual in adulthood. It is well accepted that emotional stress in early life, such as maternal separation (MS), leads to alterations in the ...
Alijanpour, Sakineh., Amini-Khoei, Hossein., Amiri, Shayan., Haj-Mirzaian, Arya., Mehdizadeh, Mehdi., Mohammadi Asl, Ali., Olson, Carl O., Rahimi-Balaei, Maryam., Rastegar, Mojgan., Razmi, Ali., Zarrindast, MohammadReza.   +10 more
core   +1 more source

D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD

Neurobiology of Disease, 2010
Low doses of psychostimulants produce beneficial behavioral effects in ADHD patients but the mechanisms underlying the response are not understood. Here we use the hyperactive mouse mutant coloboma to identify D2-like dopamine receptor subtypes that ...
Xueliang Fan, Ming Xu, Ellen J. Hess
doaj   +1 more source

Voltage sensitivity of dopamine D2-like receptors [PDF]

, 2011
G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands.
Sahlholm, Kristoffer
core   +1 more source

Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. [PDF]

, 2018
gma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and
Aguinaga Andrés, David, Canela Campos, Enric I., Franco Fernández, Rafael, Gysling, Katia, Medrano Moya, Mireia, Navarro Brugal, Gemma, Vega-Quiroga, Ignacio   +6 more
core   +1 more source

In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug

Scientific Reports, 2018
PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu, Xiaoyin Zhu, Hongbo Wang, Shanyue Sun, Xin Yue, Jingwei Tian   +5 more
doaj   +1 more source