Results 21 to 30 of about 2,841 (216)
Scientific Reports, 2018 PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu +5 more
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Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients
BMC Medical Genetics, 2001 Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether
Choi Chul-Hee +3 more
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The Dopamine/Neuroleptic Receptor [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984 ABSTRACTThe neuroleptic/dopamine receptor, with its picomolar affinity for potent neuroleptics, is the functional dopamine receptor of the brain. This receptor has been termed the D2dopamine receptor, and it inhibits or interferes with dopamine-stimulated adenylate cyclase.
D, Grigoriadis, P, Seeman
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M₅ muscarinic receptors mediate striatal dopamine activation by ventral tegmental morphine and pedunculopontine stimulation in mice. [PDF]
PLoS ONE, 2011 Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons.
Stephan Steidl +3 more
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Modulation of Neuron and Astrocyte Dopamine Receptors via Receptor–Receptor Interactions
Pharmaceuticals, 2023 Dopamine neurotransmission plays critical roles in regulating complex cognitive and behavioral processes including reward, motivation, reinforcement learning, and movement.
Diego Guidolin +6 more
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Dopamine Receptors and Neurodegeneration [PDF]
Aging and disease, 2015 Dopamine (DA) is one of the major neurotransmitters and participates in a number of functions such as motor coordination, emotions, memory, reward mechanism, neuroendocrine regulation etc. DA exerts its effects through five DA receptors that are subdivided in 2 families: D1-like DA receptors (D1 and D5) and the D2-like (D2, D3 and D4). All DA receptors
Claudia, Rangel-Barajas +2 more
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Cardiovascular Dopamine Receptors: Role of Renal Dopamine and Dopamine Receptors in Sodium Excretion [PDF]
Pharmacology & Toxicology, 1990 Research efforts in the area of peripheral dopamine have now established the presence of two distinct subtypes--DA1 and DA2--of DA receptors, and have identified a potential role for dopamine produced within the kidney in the control of renal sodium excretion.
M F, Lokhandwala, S S, Hegde
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Journal of Experimental Neuroscience, 2018 Dopamine controls various physiological functions in the brain and periphery by acting on its receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors involved in the regulation of motor activity and several neurological ...
Akanksha Mishra +2 more
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Frontiers in Endocrinology, 2020 Dopamine (DA) has a vital role in the central nervous system and also modulates lipid and glucose metabolism. The present study aimed to investigate the effect of dopamine on insulin secretion and the underlying mechanisms in rat pancreatic β-cells. Data
Mengmeng Liu +15 more
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Purkinje cell dopaminergic inputs to astrocytes regulate cerebellar-dependent behavior
Nature Communications, 2023 The role of dopamine in the cerebellum remains relatively unexplored. Here, the authors report a dopamine system in the cerebellum in mice, where Purkinje cells supply dopamine and Bergmann glia express D1 receptors.
Chang Li +7 more
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