Structure and Function Studies of the Human Dopamine Receptors [PDF]
, 2004 Dopamine neurotransmitter and its receptors play a critical role in cell signaling process responsible for information transfer in neurons functioning in the nervous system.
Kalani, M. Yashar S.
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Desensitized D2 autoreceptors are resistant to trafficking
Scientific Reports, 2017 Dendritic release of dopamine activates dopamine D2 autoreceptors, which are inhibitory G protein-coupled receptors (GPCRs), to decrease the excitability of dopamine neurons.
Brooks G. Robinson +7 more
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Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice [PDF]
, 2012 Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD.
Gispert, Suzana +11 more
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Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors
Frontiers in Pharmacology, 2020 In recent years, transmembrane voltage has been found to modify agonist potencies at several G protein-coupled receptors (GPCRs). Whereas the voltage sensitivities of the Gαi/o-coupled dopamine D2-like receptors (D2R, D3R, D4R) have previously been ...
Richard Ågren +3 more
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Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. [PDF]
PLoS ONE, 2012 The dopamine D(1), D(2), D(3) receptors, vesicular monoamine transporter type-2 (VMAT2), and dopamine transporter (DAT) densities were measured in 11 aged human brains (aged 77-107.8, mean: 91 years) by quantitative autoradiography.
Jianjun Sun +4 more
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Role of mTOR system and its relation with somatostatin and dopamine receptors on cell proliferation, hormone secretion and intracellular signalling in hepatocellular and cholangiocellular carcinomas. [PDF]
, 2011 Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are among the most lethal of human malignancies with s a very poor prognosis, with a
Pivonello, Claudia
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npj Schizophrenia, 2017 Antipsychotic drugs are widely prescribed medications, used for numerous psychiatric illnesses. However, antipsychotic drugs cause serious metabolic side effects that can lead to substantial weight gain and increased risk for type 2 diabetes.
Zachary Freyberg, Michael J. McCarthy
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Scientific Reports, 2018 PCC0104005 is a novel drug candidate for treating schizophrenia that displays high affinity for serotonin, dopamine, and noradrenaline receptors, including partial agonism at dopamine D2, D3, D4, serotonin 5-HT1A, and 5-HT2A receptors and antagonism at 5-
Yanan Xu +5 more
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Change of dopamine receptor mRNA expression in lymphocyte of schizophrenic patients
BMC Medical Genetics, 2001 Background Though the dysfunction of central dopaminergic system has been proposed, the etiology or pathogenesis of schizophrenia is still uncertain partly due to limited accessibility to dopamine receptor. The purpose of this study was to define whether
Choi Chul-Hee +3 more
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The Dopamine/Neuroleptic Receptor [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1984 ABSTRACTThe neuroleptic/dopamine receptor, with its picomolar affinity for potent neuroleptics, is the functional dopamine receptor of the brain. This receptor has been termed the D2dopamine receptor, and it inhibits or interferes with dopamine-stimulated adenylate cyclase.
D, Grigoriadis, P, Seeman
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