Results 221 to 230 of about 2,665,909 (403)

Engineering a Multifunctional Nanozyme Platform for Synergistic Melanoma Therapy: Integrating Enzyme Activity, Immune Activation, and Low‐Temperature Photothermal Effects

Angewandte Chemie, EarlyView.
This study innovatively develops a multifunctional, multienzyme‐active nanoplatform (FeCP@PDA‐GOx), aimed at overcoming the limitations of traditional cancer therapies and achieving precise, efficient, and long‐lasting melanoma treatment. By integrating starvation therapy, CDT, mPTT, and immunotherapy, FeCP@PDA‐GOx generates a multidimensional ...
Qihang Ding, Haowei Liu, Lishan Yan, Liang Chen, Yu Chen, Jong Seung Kim, Ling Mei   +6 more
wiley   +2 more sources

Impulsive-compulsive behaviour in early Parkinson's disease is determined by apathy and dopamine receptor D3 polymorphism. [PDF]

NPJ Parkinsons Dis, 2023
Theis H, Prange S, Bischof GN, Hoenig MC, Tittgemeyer M, Timmermann L, Fink GR, Drzezga A, Eggers C, van Eimeren T.   +9 more
europepmc   +1 more source

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Science, 2010
E. Chien, Wei Liu, Qiang Zhao, V. Katritch, Gye Won Han, M. Hanson, Lei Shi, A. Newman, J. Javitch, V. Cherezov, R. Stevens   +10 more
semanticscholar   +1 more source

Disruption of the blood–brain barrier contributes to neurobehavioral changes observed in rheumatic heart disease

Animal Models and Experimental Medicine, EarlyView.
Sydenham's chorea (SC) is the neurological manifestation associated with acute rheumatic fever (ARF), triggered by a group A streptococcal (GAS) infection. Anti‐GAS antibodies cross‐reacting with tissue proteins are implicated in the development of neurological changes. In this study, using an animal model, we demonstrate that a compromised blood–brain
Rukshan Ahamed Mohamed Rafeek, Riya Thapa, Samarjeet Saluja, Bipandeep Banga, David McMillan, Kadaba Sri Sriprakash, Nicholas M. Andronicos, Adam Hamlin, Natkunam Ketheesan   +8 more
wiley   +1 more source

Natural Product-Inspired Dopamine Receptor Ligands. [PDF]

J Med Chem
Dorogan M, Namballa HK, Harding WW.
europepmc   +1 more source

Regulation Mechanism of Dopamine Receptor 1 in Low Temperature Response of Marsupenaeus japonicus. [PDF]

Int J Mol Sci, 2023
Ren X, Bian X, Shao H, Jia S, Yu Z, Liu P, Li J, Li J.   +7 more
europepmc   +1 more source

Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

Nature Genetics, 1996
J. Benjamin, Lin Li, C. Patterson, B. Greenberg, D. Murphy, D. Hamer   +5 more
semanticscholar   +1 more source

Psychoses of Epilepsy: Unravelling the Phenotypic and Genotypic Features

Annals of Neurology, Volume 98, Issue 1, Page 35-47, July 2025.
Objectives We analyzed the genotypic and phenotypic features of patients with psychosis of epilepsy (POE). Methods Patients with POE recruited to an epilepsy genetics research program underwent phenotyping and genetic analysis. The latter included screening for rare pathogenic variants in epilepsy genes, and polygenic risk score (PRS) calculation for ...
Genevieve Rayner, Eliza Honybun, Melanie Bahlo, Karen L. Oliver, Ingrid E. Scheffer   +4 more
wiley   +1 more source

Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington's Disease. [PDF]

Cells
Luis-Ravelo D, Fumagallo-Reading F, Febles-Casquero A, Lopez-Fernandez J, Marcellino DJ, Gonzalez-Hernandez T.   +5 more
europepmc   +1 more source

The Neuropsychopharmacology of Phencyclidine: From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

Neuropsychopharmacology, 1999
J. Jentsch, R. Roth
semanticscholar   +1 more source