Results 91 to 100 of about 398,911 (393)

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

International Journal of Neuropsychopharmacology, 2016
Background: Our previous study demonstrated that metabolic inflammation exacerbates dopaminergic neuronal degeneration in type 2 diabetes mice. Metformin, a typical oral hypoglycemic agent for diabetes, has been regarded as an activator of AMP-activated ...
Ming Lu, Cun-Jin Su, Chen Qiao, Y. Bian, Jian-hua Ding, G. Hu   +5 more
semanticscholar   +1 more source

Long‐Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays

Advanced Science, EarlyView.
This study introduces a behavioral paradigm for memory updating and reveals underlying hippocampal mechanisms. Replays of place cells predict future behavioral choices during behavior and show a bias toward high‐reward locations during non‐rapid eye movement (NREM) sleep, specifically within the memory updating process.
Jifu Tong, Yuanwei Xing, Yawen Zheng, Linshu Wang, Shan Shao, Jiao Wu, Longyu Ma, Shuting Liu, Naizheng Liu, Xuetao Qi, Ting Wang, Kun Cui, Shuang Cui, You Wan, Ming Yi   +14 more
wiley   +1 more source

Projections of the Diencephalospinal Dopaminergic System to Peripheral Sense Organs in Larval Zebrafish (Danio rerio)

Frontiers in Neuroanatomy, 2018
Dopaminergic neurons of the descending diencephalospinal system are located in the posterior tuberculum (PT) in zebrafish (Danio rerio), and correspond in mammals to the A11 group in hypothalamus and thalamus. In the larval zebrafish, they are likely the
Melanie Haehnel-Taguchi, António M. Fernandes, António M. Fernandes, Margit Böhler, Ina Schmitt, Lena Tittel, Wolfgang Driever, Wolfgang Driever   +7 more
doaj   +1 more source

Reward Dependent Invigoration Relates to Theta Oscillations and Is Predicted by Dopaminergic Midbrain Integrity in Healthy Elderly

Frontiers in Aging Neuroscience, 2017
Motivation can have invigorating effects on behavior via dopaminergic neuromodulation. While this relationship has mainly been established in theoretical models and studies in younger subjects, the impact of structural declines of the dopaminergic system
Tineke K Steiger, N. Bunzeck
semanticscholar   +1 more source

Dopaminergic Epistases in Schizophrenia

Brain Sciences
Background: The dopaminergic theory, the oldest and most comprehensively analyzed neurotransmitter theory of schizophrenia, remains a focal point of research. Methods: This systematic review examines the association between combinations of 14 dopaminergic genes and the risk of schizophrenia.
Adela Bosun, Raluka Albu-Kalinovic, Oana Neda-Stepan, Ileana Bosun, Simona Sorina Farcas, Virgil-Radu Enatescu, Nicoleta Ioana Andreescu   +6 more
openaire   +3 more sources

High Accuracy Classification of Parkinson's Disease through Shape Analysis and Surface Fitting in $^{123}$I-Ioflupane SPECT Imaging

, 2017
Early and accurate identification of parkinsonian syndromes (PS) involving presynaptic degeneration from non-degenerative variants such as Scans Without Evidence of Dopaminergic Deficit (SWEDD) and tremor disorders, is important for effective patient ...
Ghosh, Shantanu, Mandal, Pravat K., Prashanth, R., Roy, Sumantra Dutta   +3 more
core   +1 more source

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]

, 2017
Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
core   +2 more sources

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Efficacy and Safety of Bromocriptine-QR as an Adjunctive Therapy on Glycemic Control in Subjects with Uncontrolled Type 2 Diabetes Mellitus

Journal of the ASEAN Federation of Endocrine Societies
Introduction. There has been an increasing awareness of the effects of combining bromocriptine-QR with other medications for diabetes mellitus type 2.
Theo Audi Yanto, Charista Lydia Budiputri, Michelle Patricia Muljono, Shally Chandra   +3 more
doaj   +1 more source