Results 101 to 110 of about 392,840 (300)

Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.

PLoS ONE, 2011
Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhart   +5 more
doaj   +1 more source

Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration

Nature Communications, 2016
Prokineticin-2 (PK2), a recently discovered secreted protein, regulates important physiological functions including olfactory biogenesis and circadian rhythms in the CNS.
R. Gordon, Matthew L. Neal, Jie Luo, Monica R. Langley, Dilshan S. Harischandra, Nikhil Panicker, Adhithiya Charli, Huajun Jin, V. Anantharam, T. Woodruff, Q. Zhou, A. Kanthasamy, A. Kanthasamy   +12 more
semanticscholar   +1 more source

Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation

Journal of Neuroinflammation, 2012
Background The mechanisms of progressive dopaminergic neuronal loss in Parkinson’s disease (PD) remain poorly understood, largely due to the complex etiology and multifactorial nature of disease pathogenesis.
Gordon Richard, Anantharam Vellareddy, Kanthasamy Anumantha G, Kanthasamy Arthi   +3 more
doaj   +1 more source

A Local Circuit Model of Learned Striatal and Dopamine Cell Responses under Probabilistic Schedules of Reward [PDF]

, 2007
Before choosing, it helps to know both the expected value signaled by a predictive cue and the associated uncertainty that the reward will be forthcoming. Recently, Fiorillo et al.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source

Pain-motor integration in the primary motor cortex in Parkinson's disease [PDF]

, 2017
In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through ...
Berardelli, Alfredo, Biasiotta, A, Cruccu, Giorgio, Di Santo, A, DI STASIO, Flavio, LA CESA, Silvia, Leone, Caterina, Marsili, Luca, Suppa, Antonio, Truini, Andrea   +9 more
core   +1 more source

Speech and Language Development in children with hyperkinetic disorder in children under conditions of pathogenetic heterogeneity

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018
The frequency and expected mechanisms of comorbidity of hyperkinetic disorder with dyslasia, dyslexia, dysgraphia and dyscalculia are considered in the article.
R. F. Gasanov
doaj  

Transdifferentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Dopaminergic Neurons in a Three-Dimensional Culture

Basic and Clinical Neuroscience, 2022
Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including
Ardeshir Moayeri, Rafieh Alizadeh, Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi, Ali Niapour, Azim Hedayatpour, Marzieh Darvishi, Fatemeh Heidari, Maryam Soleimani, Leila Elyasi   +9 more
doaj  

Dopaminergic Regulation of Neuronal Circuits in Prefrontal Cortex [PDF]

, 2001
Neuromodulators, like dopamine, have considerable influence on the\ud processing capabilities of neural networks. \ud This has for instance been shown in the working memory functions\ud of prefrontal cortex, which may be regulated by altering the\ud ...
Scheler, Gabriele
core  

Diversity matters – heterogeneity of dopaminergic neurons in the ventral mesencephalon and its relation to Parkinson's Disease

Journal of Neurochemistry, 2016
Dopaminergic neurons in the ventral mesencephalon (the ventral mesencephalic dopaminergic complex) are known for their role in a multitude of behaviors, including cognition, reward, addiction and voluntary movement.
D. V. Vogt Weisenhorn, F. Giesert, W. Wurst   +2 more
semanticscholar   +1 more source

A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons [PDF]

, 2007
The "teaching signal" that modulates reinforcement learning at cortico-striatal synapses may be a sequence composed of an adaptively scaled DA burst, a brief ACh burst, and a scaled ACh pause.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source