Results 101 to 110 of about 240,256 (373)
Frontiers in Neuroanatomy, 2010 Cholinergic and dopaminergic projections to the rat medial prefrontal cortex (mPFC) are both involved in cognitive functions including attention. These neuronal systems modulate mPFC neuronal activity mainly through diffuse transmission.
Zi-Wei Zhang +5 more
doaj +1 more source
Creativity and Delusions: A Neurocomputational Approach [PDF]
arXiv, 2000 Thinking is one of the most interesting mental processes. Its complexity is sometimes simplified and its different manifestations are classified into normal and abnormal, like the delusional and disorganized thought or the creative one. The boundaries between these facets of thinking are fuzzy causing difficulties in medical, academic, and ...
arxiv
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
Advanced Science, EarlyView.This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu +9 more
wiley +1 more source
PLoS ONE, 2011 Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis +5 more
doaj +1 more source
A Computational Model of the Effects of Drug Addiction on Neural Population Dynamics [PDF]
arXiv, 2012 Reward processing and derangements thereof, such as drug addiction, involve the coordinated activity of many brain areas. Prior work has identified many behavioral, molecular biological and single neuron changes throughout the mesocorticolimbic system that reflect and drive addictive behavior.
arxiv
Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
Advanced Science, EarlyView.The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong +11 more
wiley +1 more source
Journal of Neuroinflammation, 2012 Background The mechanisms of progressive dopaminergic neuronal loss in Parkinson’s disease (PD) remain poorly understood, largely due to the complex etiology and multifactorial nature of disease pathogenesis.
Gordon Richard +3 more
doaj +1 more source
Reinforcement Learning in a Neurally Controlled Robot Using Dopamine Modulated STDP [PDF]
arXiv, 2015 Recent work has shown that dopamine-modulated STDP can solve many of the issues associated with reinforcement learning, such as the distal reward problem. Spiking neural networks provide a useful technique in implementing reinforcement learning in an embodied context as they can deal with continuous parameter spaces and as such are better at ...
arxiv
Antidepressant-like Effects of Neuropeptide SF (NPSF) [PDF]
World Journal of Research and Review (WJRR) ISSN:2455-3956,
Volume-4, Issue-5, May 2017 Pages 26-30, 2020 Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse roles in central nervous system. Little is know about the effects of NPSF on brain functions. Antidepressant-like effect of NPSF was studied in modified mice FST. NPSF showed the antidepressant-like effects by decreasing the immobility time and increasing the climbing and ...
arxiv
Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence
Nature Neuroscience, 2014 We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest.
Colin G. McNamara +4 more
semanticscholar +1 more source