Results 111 to 120 of about 392,840 (300)
Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence
Nature Neuroscience, 2014 We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest.
Colin G. McNamara +4 more
semanticscholar +1 more source
Neural Regeneration ResearchParkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin +8 more
doaj +1 more source
Electron microscopy analysis of alpha-synuclein and LRRK2 transgenic C. elegans [PDF]
, 2013 Thesis (M.A.)--Boston UniversityMutations in alpha-synuclein and leucine-rich repeat kinase 2 (LRRK2) have been implicated in the cause of Parkinson’s disease (PD).
Nguyen, Andrew Huy
core +1 more source
Parkinson’s disease: animal models and dopaminergic cell vulnerability
Frontiers in Neuroanatomy, 2014 Parkinson’s disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the ...
J. Blesa, S. Przedborski
semanticscholar +1 more source
Design and Synthesis of Dopaminergic Agonists
Current Medicinal Chemistry, 2016 The use of dopaminergic agonists is key in the treatment of Parkinson's disease and related central nervous system (CNS) neurodegenerative disorders. Despite there are a number of commercialized dopaminergic agonists that are currently being used successfully in the first stages of the disease, they often fail to provide sustained clinical benefit for ...
Matute, Maria Soledad +2 more
openaire +3 more sources
Bio-Protocol, 2018 The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals.
Sarah-Lena Offenburger, Anton Gartner
doaj +1 more source
CellsDopaminergic neurons are the predominant brain cells affected in Parkinson’s disease. With the limited availability of live human brain dopaminergic neurons to study pathological mechanisms of Parkinson’s disease, dopaminergic neurons have been generated
Kirstin O. McDonald +6 more
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MAZINDOL ANOREXIA IS MEDIATED BY ACTIVATION OF DOPAMINERGIC MECHANISMS [PDF]
, 1976 Zygmunt L. Kruk, M.R. Zarrindast
openalex +1 more source
Journal of Biological Chemistry, 2008 α-Synuclein, a protein implicated in the pathogenesis of Parkinson disease (PD), is thought to affect mitochondrial functions, although the mechanisms of its action remain unclear.
L. Devi +4 more
semanticscholar +1 more source
Compromised Dynamic Cerebral Autoregulation in Patients with Restless Legs Syndrome
Nature and Science of SleepYanan Zhang,1 Qianqian Chen,1 Qingqing Sun,1 Mingyang Tang,1 Yi Yang,1,2 Zhen-Ni Guo,1,2 Zan Wang1,2 1Sleep Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, People’s Republic of China; 2Stroke Center, Department of ...
Zhang Y +6 more
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