Results 111 to 120 of about 240,256 (373)
Advances in CRISPR‐Cas9 in lineage tracing of model animals
Animal Models and Experimental Medicine, EarlyView.Cell lineage tracing is a key technology for describing the developmental history of individual progenitor cells and assembling them to form a lineage development tree. However, traditional methods have limitations of poor stability and insufficient resolution.
Jingchao Cao +5 more
wiley +1 more source
Basic and Clinical Neuroscience, 2022 Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including
Ardeshir Moayeri +9 more
doaj
An Explainable Machine Learning Model for Early Detection of Parkinson's Disease using LIME on DaTscan Imagery [PDF]
arXiv, 2020 Parkinson's disease (PD) is a degenerative and progressive neurological condition. Early diagnosis can improve treatment for patients and is performed through dopaminergic imaging techniques like the SPECT DaTscan. In this study, we propose a machine learning model that accurately classifies any given DaTscan as having Parkinson's disease or not, in ...
arxiv
Journal of Neurochemistry, 2016 Dopaminergic neurons in the ventral mesencephalon (the ventral mesencephalic dopaminergic complex) are known for their role in a multitude of behaviors, including cognition, reward, addiction and voluntary movement.
D. V. Vogt Weisenhorn +2 more
semanticscholar +1 more source
Cyclic Alternating Pattern Dynamics in Individuals at Risk for Developing Parkinson's Disease
Annals of Neurology, Volume 98, Issue 1, Page 136-146, July 2025.Objective The objective of this study was to investigate the differences in cyclic alternating patterns (CAP) metrics, a non‐rapid eye movement (NREM) sleep physiological rhythm, among recently diagnosed patients with Parkinson's disease (PD), and individuals at high and low risk for developing PD based on genetic and prodromal risk.
Andrew Dagay +5 more
wiley +1 more source
Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018 The frequency and expected mechanisms of comorbidity of hyperkinetic disorder with dyslasia, dyslexia, dysgraphia and dyscalculia are considered in the article.
R. F. Gasanov
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Deep brain stimulation for movement disorder treatment: Exploring frequency-dependent efficacy in a computational network model [PDF]
arXiv, 2020 A large scale computational model of the basal ganglia (BG) network is proposed to describes movement disorder including deep brain stimulation (DBS). The model of this complex network considers four areas of the basal ganglia network: the subthalamic nucleus (STN) as target area of DBS, globus pallidus, both pars externa and pars interna (GPe-GPi ...
arxiv
Parkinson’s disease: animal models and dopaminergic cell vulnerability
Frontiers in Neuroanatomy, 2014 Parkinson’s disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. A hallmark feature of PD is the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta (SNc) and the ...
J. Blesa, S. Przedborski
semanticscholar +1 more source
Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease
Annals of Neurology, Volume 98, Issue 1, Page 120-135, July 2025.Objective Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase ...
Verena Dzialas +4 more
wiley +1 more source
Compromised Dynamic Cerebral Autoregulation in Patients with Restless Legs Syndrome
Nature and Science of SleepYanan Zhang,1 Qianqian Chen,1 Qingqing Sun,1 Mingyang Tang,1 Yi Yang,1,2 Zhen-Ni Guo,1,2 Zan Wang1,2 1Sleep Center, Department of Neurology, The First Hospital of Jilin University, Chang Chun, People’s Republic of China; 2Stroke Center, Department of ...
Zhang Y +6 more
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