Results 121 to 130 of about 240,256 (373)
Bio-Protocol, 2018 The nematode Caenorhabditis elegans is a powerful genetic model that can be used to investigate neuronal death. Research using C. elegans has been crucial to characterize cell death programmes that are conserved in mammals.
Sarah-Lena Offenburger, Anton Gartner
doaj +1 more source
High level modeling of tonic dopamine mechanisms in striatal neurons [PDF]
arXiv, 2007 The extant versions of many basal ganglia models use a `gating' model of dopamine function which enhances input to D1 receptor units and attenuates input to D2 receptor units. There is evidence that this model is unsatisfactory because (a) there are not sufficient dopaminergic synapses to gate all input and (b) dopamine's main effect is likely to be on
arxiv
Lab on a Chip, 2015 A hallmark of Parkinson's disease is the progressive loss of nigrostriatal dopaminergic neurons. We derived human neuroepithelial cells from induced pluripotent stem cells and successfully differentiated them into dopaminergic neurons within phase-guided,
E. L. Moreno +8 more
semanticscholar +1 more source
Design and Synthesis of Dopaminergic Agonists
Current Medicinal Chemistry, 2016 The use of dopaminergic agonists is key in the treatment of Parkinson's disease and related central nervous system (CNS) neurodegenerative disorders. Despite there are a number of commercialized dopaminergic agonists that are currently being used successfully in the first stages of the disease, they often fail to provide sustained clinical benefit for ...
Matute, Maria Soledad +2 more
openaire +3 more sources
Cholinergic Degeneration and Cognitive Function in Early GBA1‐Related Parkinson's Disease
Annals of Neurology, EarlyView.Objective The phenotype of patients with Parkinson's disease carrying GBA1 variants (GBA‐PD) suggest similarities to symptomatology associated with early cholinergic system degeneration. Therefore, this study aims to investigate the clinical features and the cholinergic innervation pattern in patients with early GBA‐PD versus those without the GBA1 ...
Sofie Slingerland +6 more
wiley +1 more source
Co-operativity in neurons and the role of noise in brain [PDF]
arXiv, 2007 In view of some recent results in case of the dopaminergic neurons exhibiting long range correlations in VTA of the limbic brain we are interested to find out whether any stochastic nonlinear response may be reproducible in the nano scales usimg the results of quantum mechanics.
arxiv
JAMA Neurology, 2015 IMPORTANCE Little is known about the relative contributions of multisystem degenerative processes across the spectrum of predemented cognitive decline in Parkinson disease (PD).
N. Bohnen +7 more
semanticscholar +1 more source
SPLICEIT Fluorescent Sensor for Integrating Dopamine Release with Cellular Resolution
Angewandte Chemie International Edition, Accepted Article.Dopamine is a neurotransmitter essential for motor control, reward processing, and motivation through G‐protein coupled receptor (GPCR) signaling. Recent GPCR‐based real‐time sensors allow for optical monitoring of dopamine release in behaving animals.
Steven M. Havens +7 more
wiley +1 more source
Neural Regeneration ResearchParkinson’s disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra compacta. Ferroptosis, a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation, plays a vital role in the death of ...
Zhihao Lin +8 more
doaj +1 more source
Biophysics of risk aversion based on neurotransmitter receptor theory [PDF]
Neuro Endocrinol Lett. 2008 Aug;29(4):399-404.
http://node.nel.edu/?node_id=7744, 2011 Decision under risk and uncertainty has been attracting attention in neuroeconomics and neuroendocrinology of decision-making. This paper demonstrated that the neurotransmitter receptor theory-based value (utility) function can account for human and animal risk-taking behavior.
arxiv