Results 341 to 350 of about 398,911 (393)
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Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.
ACS Chemical Neuroscience, 2019N6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in the mRNA of eukaryotes and plays a vital role in the post-transcriptional regulation.
Xuechai Chen +10 more
semanticscholar +1 more source
Dopaminergic properties of nomifensine
Pharmacology Biochemistry and Behavior, 1982Nomifensine and a proposed dihydroxy metabolite produced stimulation of motor behavior in mice with nomifensine being more potent. Weak cage-climbing behavior (stereotypy) was also produced. The stimulatory effects were greater in mice in which dopamine receptor sensitivity was increased by long-term haloperidol.
G, Gianutsos +3 more
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Is there a ?dopaminergic glial cell??
Neurochemical Research, 1984Intracellular cAMP increased 9-fold in cerebral hemisphere primary cultures after incubation with dopamine (10(-4) M). The effect was dose- and time-dependent (10(-6) M-10(-4) M; 2-10 minutes). It was mimicked, to some extent, by the partial agonist apomorphine (10(-5) M-10(-4) M) and antagonized by fluphenazine (10(-5) M-10(-4) M).
E, Hansson, L, Rönnbäck, A, Sellström
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The dopaminergic system in hypertension
Clinical Science, 2007Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport, vascular smooth muscle contractility and production of reactive oxygen species and by interacting with the renin–angiotensin and sympathetic nervous systems.
Chunyu, Zeng +4 more
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Dopaminergic influences on swallowing☆
Neuropharmacology, 1977Abstract Oropharyngeal twitch activity (OTA) exhibited spontaneously in the rat under urethane anaesthesia was compared with swallowing elicited reflexly by electrical stimulation of the superior laryngeal nerve (SLN) or intraoral injection of water. Deglutition was monitored by recording EMGs from muscles of the floor of the mouth, neck and pharynx,
D, Bieger, S A, Giles, C H, Hockman
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Nature, 1978
THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
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THE clinical treatment of parkinsonism with the dopamine (DA) precursor L-dopa has certain drawbacks1 and there are relatively few drugs which directly stimulate DA receptors (although there are many which block them, such as the neuroleptics). There is thus great industrial, academic and clinical interest in the development of new DA-receptor ...
A S, Horn +7 more
openaire +3 more sources
Dopaminergic defect in hypertension
Pediatric Nephrology, 1993Reverse genetics and the candidate gene approach have been utilized to identify the genetic defect(s) in hypertension. We have proposed the dopamine receptor gene as one candidate in the pathogenesis of hypertension. Because some forms of hypertension are sodium dependent or aggravated by sodium loading and because dopamine is important in aiding the ...
P A, Jose, G M, Eisner, R A, Felder
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Dopaminergic activity of quipazine
Pharmacology Biochemistry and Behavior, 1982Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Administration of 1.0 mg/kg quipazine, a putative serotonin agonist, produced apomorphine-appropriate responding with a maximal effect occurring at 45 min post-injection.
M D, Schechter, J T, Concannon
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Ethanol and dopaminergic systems
Pharmacology Biochemistry and Behavior, 1983Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the
Lucchi L +5 more
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[Continuous dopaminergic stimulation, pulsatile dopaminergic stimulation].
Revue neurologique, 2003Levodopa is the gold standard treatment for Parkinson's disease. The therapeutic effect may however be compromised by the inevitable risk of motor complications, with fluctuating motor control and dyskinesia, particularly in the younger patient. The Multiple pathophysiological mechanisms are undoubtedly involved but pulsed dopaminergic stimulation ...
A., Destée, R., Bordet
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