Results 301 to 310 of about 835,318 (379)

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. [PDF]

Mol Neurodegener
Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.   +34 more
europepmc   +1 more source

Cochlear Cell Atlas of Two Laryngeal Echolocating Bats—New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat

Molecular Ecology Resources, EarlyView.
ABSTRACT Bats have evolved highly adapted auditory mechanisms associated with ecological specialisation. However, there is scattered knowledge about the neurophysiological and cellular basis underlying high‐frequency hearing in echolocating bats. Herein, the total cochlear cell atlas of Rhinolophus ferrumequinum (constant frequency (CF) bat) and Myotis
Xue Wang, Mingyue Bao, Hui Wang, Ruyi Sun, Wentao Dai, Keping Sun, Yue Zhu, Yingting Pu, Yujia Chu, Xintong Li, Tianhui Wang, Minjie Zhang, Aiqing Lin, Jiqian Li, Jiang Feng   +14 more
wiley   +1 more source

Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. [PDF]

Mol Neurodegener
Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.   +34 more
europepmc   +1 more source

Physical Exercise Decreases Complement‐Mediated Synaptic Loss and Protects Against Cognitive Impairment by Inhibiting Microglial Tmem9‐ATP6V0D1 in Alzheimer's Disease

Aging Cell, EarlyView.
In a 5xFAD mouse model, we observed that physical exercise reduced the levels of microglial Tmem9, thereby inhibiting complement activation through its interaction with ATP6V0D1. Consequently, this attenuation of complement‐dependent synaptic loss led to significant improvements in both emotional and cognitive impairments. ABSTRACT Physical exercise is
Shiyin Li, Mingyue Li, Ge Li, Lili Li, Xiaofeng Yang, Zejie Zuo, Liying Zhang, Xiquan Hu, Xiaofei He   +8 more
wiley   +1 more source

Retraction Note: 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons. [PDF]

BMC Neurosci
Schommer J, Marwarha G, Schommer T, Flick T, Lund J, Ghribi O.   +5 more
europepmc   +1 more source

Enhanced Microglial Engulfment of Dopaminergic Synapses Induces Parkinson's Disease‐Related Executive Dysfunction in an Acute LPC Infusion Targeting the mPFC

Aging Cell, EarlyView.
Parkinson's disease with executive dysfunction is a challenge. Our study reveals a novel pathway where abnormally elevated LPC induces miR‐2885/TDP‐43 signal activation in microglia, leading to dopaminergic terminal phagocytosis, and suggests that supplementing dopamine or inhibiting related microglial activation can mitigate the dysfunction, providing
Yehao Liu, Rui Chen, Chunyan Mu, Junjie Diao, Yurong Guo, Xiaoyu Yao, Shijie Shi, Mengying Wang, Zhi Zhang, Xiaoling Qin, Chuanxi Tang   +10 more
wiley   +1 more source

The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior. [PDF]

Elife
Wang J, Su M, Zhang D, Zhang L, Niu C, Li C, You S, Sang Y, Zhang Y, Du X, Zhang H.   +10 more
europepmc   +1 more source

IGF2‐Reprogrammed Macrophages Ameliorate the Inflammatory Response and Protect Against the Neuroinflammatory Process in Parkinson's Disease Models

Aging Cell, EarlyView.
Therapeutic Effects of IGF2‐Reprogrammed Macrophages (MIGF2) in Parkinson's Disease Progression in ASO Mice: This graphical abstract illustrates the therapeutic potential of IGF2‐reprogrammed macrophages (MIGF2) in mitigating Parkinson's disease progression in ASO mice.
Felipe Grunenwald, Tomas J. Huerta, Denisse Sepulveda, Carolina Jerez, Valentina Urbina, Bárbara Carrera, Rodrigo Diaz‐Espinoza, Esteban Nova, Rodrigo Pacheco, Elisa Martín‐Montañez, Sara Gil‐Rodriguez, Nadia Valverde, María Garcia‐Fernandez, Carlos Aguilera, Pedro Chana‐Cuevas, René L. Vidal   +15 more
wiley   +1 more source

P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson's disease. [PDF]

CNS Neurosci Ther
Chen Y, Zhu Z, Yan Y, Sun H, Wang G, Du X, Li F, Yuan S, Wang W, Wang M, Gu C.   +10 more
europepmc   +1 more source

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source