Results 31 to 40 of about 2,975,612 (292)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Tradução, adaptação cultural e validação da versão portuguesa do instrumento “knowledge and attitudes survey regarding pain” (kasrp)

open access: yesOnco.News, 2019
As lacunas na formação dos profissionais de saúde têm sido apontadas como a principal causa de sofrimento inaceitável à luz do conhecimento atual. O Knowledge and Attitudes Survey Regarding Pain (KASRP) é um instrumento com 41 itens que mede as ...
Luís Manuel Batalha   +8 more
doaj   +1 more source

Dor oncológica

open access: yesRevista Portuguesa de Pneumologia, 2007
A dor pode ser definida de várias formas, sendo habitualmente descrita como uma experiência sensorial e emocional desagradável associada a lesão tecidular real ou potencial, ou descrita em função de tal lesão. No doente oncológico, a dor pode estar relacionada com a neoplasia, com o seu tratamento, ou não ter relação com a doença neoplásica.
Carla Alves Costa   +3 more
openaire   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

Critérios de referenciação de pessoas com dor dos Cuidados de Saúde Primários para consulta em Unidade de Dor hospitalar e de contrarreferenciação para os Cuidados de Saúde Primários

open access: yesRevista Dor
Objetivo: Este documento visa propor critérios de referenciação dos Cuidados de Saúde Primários (CSP) para Unidades de Dor (UD) Hospitalares e os critérios de alta destas unidades e referenciação para os CSP, assegurando uma continuidade de cuidados ...
Filipe Antunes   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

Endometriosis: A Disease with Few Direct Treatment Options

open access: yesMolecules, 2022
Endometriosis is a gynecological condition characterized by the growth of endometrium-like tissues inside and outside the pelvic cavity. The evolution of the disease can lead to infertility in addition to high treatment costs.
Patricia Ribeiro de Carvalho França   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Randomized prospective study of three different techniques for ultrasound-guided axillary brachial plexus block

open access: yesBrazilian Journal of Anesthesiology, 2018
Introduction: Randomized prospective study comparing two perivascular techniques with the perineural technique for ultrasound-guided axillary brachial plexus block (US-ABPB).
Leonardo Henirque Cunha Ferraro   +5 more
doaj   +1 more source

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