Results 41 to 50 of about 48,986 (260)

Effects of the positive end-expiratory pressure increase on sublingual microcirculation in patients with acute respiratory distress syndrome

Brazilian Journal of Anesthesiology, 2017
Objective: The aim of this study was to evaluate the impact of increased positive end-expiratory pressure on the sublingual microcirculation. Methods: Adult patients who were sedated, under mechanical ventilation, and had a diagnosis of circulatory shock
Nathaly Fonseca Nunes, Antônio Tonete Bafi, Eduardo Souza Pacheco, Luciano Cesar Pontes de Azevedo, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas   +5 more
doaj   +1 more source

Fatigue, depression, and physical activity in patients with malignant hyperthermia: a cross-sectional observational study

Brazilian Journal of Anesthesiology, 2023
Background: Malignant Hyperthermia (MH) is a pharmacogenetic disorder triggered by halogenated anesthesia agents/succinylcholine and characterized by hypermetabolism crisis during anesthesia, but also by day-to-day symptoms, such as exercise intolerance,
P..mela Vieira de Andrade, L.ívia Maria Valim, Joilson Moura dos Santos, Isac de Castro, Jos.. Luiz Gomes do Amaral, Helga Cristina Almeida da Silva   +5 more
doaj   +1 more source

Dor orofacial e mecanismos de dor referida

Research, Society and Development, 2022
A dor orofacial é como uma sensação mais ou menos localizada de desconforto, angústia, ou agonia, resultado da estimulação de extremidades nervosas especializadas. Ela serve como um mecanismo protetor contra a injúria. Apesar dessas informações iniciais, tem-se que a complexidade dos mecanismos neurofisiológicos, neuroquímicos e psicológicos faz tornar
Cariny Regino de Almeida, Mosaniel Falcão de França Junior   +1 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Transfusional profile in different types of intensive care units

Brazilian Journal of Anesthesiology, 2014
Background and objectives: anemia is a common clinical finding in intensive care units. The red blood cell transfusion is the main form of treatment, despite the associated risks.
Ilusca Cardoso de Paula, Luciano Cesar Pontes Azevedo, Luiz Fernando dos Reis Falcão, Bruno Franco Mazza, Melca Maria Oliveira Barros, Flavio Geraldo Rezende Freitas, Flávia Ribeiro Machado   +6 more
doaj   +1 more source

Dor oncológica

Revista Portuguesa de Pneumologia, 2007
A dor pode ser definida de várias formas, sendo habitualmente descrita como uma experiência sensorial e emocional desagradável associada a lesão tecidular real ou potencial, ou descrita em função de tal lesão. No doente oncológico, a dor pode estar relacionada com a neoplasia, com o seu tratamento, ou não ter relação com a doença neoplásica.
Carla Alves Costa, Cristina Santos, Paula Alves, Agostinho Costa   +3 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source