Results 61 to 70 of about 916,549 (292)

Effects of the positive end-expiratory pressure increase on sublingual microcirculation in patients with acute respiratory distress syndrome

Brazilian Journal of Anesthesiology, 2017
Objective: The aim of this study was to evaluate the impact of increased positive end-expiratory pressure on the sublingual microcirculation. Methods: Adult patients who were sedated, under mechanical ventilation, and had a diagnosis of circulatory shock
Nathaly Fonseca Nunes, Antônio Tonete Bafi, Eduardo Souza Pacheco, Luciano Cesar Pontes de Azevedo, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas   +5 more
doaj   +1 more source

Brown Dwarfs in Young Moving Groups from Pan-STARRS1. I. AB Doradus

, 2015
Substellar members of young ($\lesssim$150 Myr) moving groups are valuable benchmarks to empirically define brown dwarf evolution with age and to study the low-mass end of the initial mass function.
Aller, Kimberly M., Best, William M. J., Burgett, William S., Chambers, Kenneth C., Flewelling, Heather, Hodapp, Klaus W., Kaiser, Nick, Kotson, Michael C., Liu, Michael C., Magnier, Eugene A., Metcalf, Nigel, Tonry, John L., Wainscoat, Richard J., Waters, Christopher   +13 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Perturbação de Dor

, 2008
A perturbação de dor é uma perturbação psiquiátrica diagnosticada quando a dor se torna o foco predominante da apresentação clínica e causa sofrimento ou deterioração significativa. Para além do elevado impacto económico, existe uma relação recíproca com o estado afectivo.
Capela, C, Loura, R
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Procedimentos intervencionistas para o manejo da dor no câncer

Einstein (São Paulo), 2012
OBJETIVO: Descrever tipos de procedimentos (seu uso racional e alguns de seus benefícios) realizados em pacientes com câncer tratados em um hospital privado de São Paulo.
Fabiola Peixoto Minson, Fabrício Dias Assis, Thais Kfouri Vanetti, Jamir Sardá Junior, Wanessa Pereira Mateus, Auro Del Giglio   +5 more
doaj  

Radiofrequência percutânea guiada por ecografia do grupo pericapsular nervoso (PENG ) para tratamento da dor crónica da anca em doentes com coxartrose

Revista Dor
A coxartrose é uma causa comum de dor crónica da anca (DCA), com um impacto funcional significativo e o seu tratamento inclui medicação analgésica, programas de reabilitação, procedimentos minimamente invasivos e cirurgia.
Filipa Gouveia, Marta Caldeira, Duarte Correia   +2 more
doaj   +1 more source