Results 61 to 70 of about 137,559 (269)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Clinical presentation and diagnosis of neuropathic pain

, 2016
BACKGROUND AND OBJECTIVES: Neuropathic pain is reason for distress and incapacity of several patients, being that symptoms, mechanisms and management distinguish it from nociceptive pain.
Barros, Guilherme Antônio Moreira De, Colhado, Orlando Carlos Gomes, Giublin, Mário Luiz   +2 more
core   +1 more source

Acupuncture to manage orofacial pain and tinnitus: Case report [PDF]

, 2015
BACKGROUND AND OBJECTIVES: Orofacial pain is associated to soft and mineralized oral cavity and facial tissues. In dentistry, it may have or not odontogenic origin.
Vera, Rosario Martha De La Torre, Berzin, Fausto, Grillo, Cássia Maria, Fortinguerra, Maria Lucia B., Sousa, María da Luz R.   +4 more
core   +1 more source

Effects of the positive end-expiratory pressure increase on sublingual microcirculation in patients with acute respiratory distress syndrome

Brazilian Journal of Anesthesiology, 2017
Objective: The aim of this study was to evaluate the impact of increased positive end-expiratory pressure on the sublingual microcirculation. Methods: Adult patients who were sedated, under mechanical ventilation, and had a diagnosis of circulatory shock
Nathaly Fonseca Nunes, Antônio Tonete Bafi, Eduardo Souza Pacheco, Luciano Cesar Pontes de Azevedo, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Concepções e contribuições de enfermeiras que atuam em cuidados paliativos sobre a avaliação da dor de pacientes com câncer: uma prática de educação no trabalho [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Enfermagem.Trata-se de uma pesquisa do tipo convergente-assistencial, de natureza qualitativa, cujo objetivo foi revelar as ...
Waterkemper, Roberta
core  

Vitamin D and chronic pain in the elderly [PDF]

, 2013
BACKGROUND AND OBJECTIVES: Chronic pain is a frequent complaint during medical visits, especially among the elderly. In the attempt to find more effective therapies with less adverse effects in this population, especially considering elderly people with ...
Moraes, Niele [UNIFESP], Oliveira, Welington Saraiva De [UNIFESP], Santos, Fania Cristina [UNIFESP]   +2 more
core   +1 more source