Results 81 to 90 of about 916,549 (292)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Precautionary saving in the presence of other risks: further comment [PDF]
precautionary saving; background ...
Eric Dor
core
Short and long term results of the laparoscopic Heller–Dor myotomy. The influence of age and previous conservative therapies [PDF]
, 2007 Analisi dei risultati della terapia chirurgica dell'acalasia esofagea con tecnica di Heller-Dor laparoscopica in pazienti anziani con e senza dilatazione pneumatica ...
DOMENICO FICO AND DOMENICO PELAGGI +5 more
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Peripheral nerve block and rebound pain: literature review
Brazilian Journal of Anesthesiology, 2019 Background and objectives: To investigate, describe, and assess the phenomenon of “rebound pain” as a clinically relevant problem in anesthetic practice. Content: The phenomenon of “rebound pain” has been demonstrated and described as a very severe pain,
Layana Vieira Nobre +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Brazilian Journal of AnesthesiologyIntroduction: Simulation-based training is particularly beneficial for rare and life-threatening diseases such as Malignant Hyperthermia (MH). In addition, cognitive aids, including flowcharts and checklists, can be used as guidance in crisis, reducing ...
Mariana F.L. Neville +10 more
doaj +1 more source
Pain management in children with erythromelalgia: case report
Brazilian Journal of Anesthesiology, 2018 Erythromelalgia is a neuropathic pain syndrome due to an autosomal dominant gene, characterized by erythema, increased skin temperature and burning pain in hands and feet, whose treatment is often unsatisfactory.
Estela Irene Bortoli +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Neurociência da dor: exercícios para dor crônica
Estudios y Perspectivas Revista Científica y AcadémicaIntrodução: Na dor crônica, o sistema nervoso muitas vezes se torna hiperativo, gerando dor persistente e debilitante. Compreender os mecanismos neurobiológicos por trás da dor crônica é crucial para desenvolver tratamentos mais eficazes. Objetivo: Compreender a importância da neurociência relacionando para os exercícios para dor crônica.
LUIZ FELIPE CHAVES CARVALHO +1 more
openaire +1 more source