Results 91 to 100 of about 110,611 (310)

Perturbação de Dor

, 2008
A perturbação de dor é uma perturbação psiquiátrica diagnosticada quando a dor se torna o foco predominante da apresentação clínica e causa sofrimento ou deterioração significativa. Para além do elevado impacto económico, existe uma relação recíproca com o estado afectivo.
Capela, C, Loura, R
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pain management in children with erythromelalgia: case report

Brazilian Journal of Anesthesiology, 2018
Erythromelalgia is a neuropathic pain syndrome due to an autosomal dominant gene, characterized by erythema, increased skin temperature and burning pain in hands and feet, whose treatment is often unsatisfactory.
Estela Irene Bortoli, Rioko Kimiko Sakata   +1 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Alternative treatment for post-herpetic neuralgia after lung transplantation. Case report

, 2012
JUSTIFICATIVA E OBJETIVOS: A neuralgia pós-herpética (NPH) é a dor que permanece após o desaparecimento do episódio agudo de herpes zoster. O objetivo deste estudo foi relatar o tratamento da dor da NPH em paciente transplantado pulmonar. RELATO DO CASO:
Silva, Magda Aparecida Santos da, Pereira, Mara Helena Corso, Zylbersztejn, Fernando Henrique Machado de Carvalho, Vasconcelos Filho, Paulo de Oliveira   +3 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Pain management after outpatient surgical procedure

, 2013
BACKGROUND AND OBJECTIVES: Adequate postoperative pain control is critical for any outpatient surgical procedure. This study aimed at evaluating analgesics and techniques used to manage pain of this type of procedure.
Munechika, Masashi [UNIFESP], Pereira, Rodney Junqueira [UNIFESP], Sakata, Rioko Kimiko [UNIFESP]   +2 more
core   +1 more source

A DOR

Revista Gestão & Saúde, 2014
Poesia
openaire   +3 more sources

Evaluation of anesthesiology residents in the diagnosis and control of malignant hyperthermia: comparison of three scenarios of realistic simulation ‒ a cross-sectional controlled study

Brazilian Journal of Anesthesiology
Introduction: Simulation-based training is particularly beneficial for rare and life-threatening diseases such as Malignant Hyperthermia (MH). In addition, cognitive aids, including flowcharts and checklists, can be used as guidance in crisis, reducing ...
Mariana F.L. Neville, Victor Guimarães de Almeida, Pamela Vieira Andrade, Joilson Moura Santos, Masashi Munechika, David Ferez, Mary dos Santos Silva, Leonardo Ayres Canga, Ana Cristina Tripoloni, Thierry Girard, Helga Cristina Almeida da Silva   +10 more
doaj   +1 more source

Peripheral nerve block and rebound pain: literature review

Brazilian Journal of Anesthesiology, 2019
Background and objectives: To investigate, describe, and assess the phenomenon of “rebound pain” as a clinically relevant problem in anesthetic practice. Content: The phenomenon of “rebound pain” has been demonstrated and described as a very severe pain,
Layana Vieira Nobre, Graziella Prianti Cunha, Paulo César Castello Branco de Sousa, Alexandre Takeda, Leonardo Henrique Cunha Ferraro   +4 more
doaj   +1 more source