Results 121 to 130 of about 9,718 (285)

A first in disease trial of the safety, tolerability, and anti‐seizure effects of ES‐481 in drug‐resistant epilepsy

Epilepsia Open, EarlyView.
Abstract Objectives ES‐481 is a novel potent and selective antagonist of TARP‐y8‐dependent AMPA receptors. We aimed to assess the potential efficacy, safety and tolerability, and pharmacokinetics of different doses of ES‐481 as an add‐on anti‐seizure medication (ASM) in adults with drug‐resistant epilepsy (DRE). Methods This was a Phase 2A double‐blind,
Emma C. Foster, Lyn Millist, Jack Germaine, Stephanie Chamorro, Caitlin Roberts, John‐Paul Nicolo, Sean Hosking, Piero Perucca, Saul Mullen, Heather Robinson, Rebecca Wharrie, Brittany Walsh, David Reutens, Kimberley Irwin, Hao Zeng, Robert Niecestro, Terence J. O'Brien   +16 more
wiley   +1 more source

Impact of evidence‐based information on horse owners' misconceptions of colic

Equine Veterinary Journal, EarlyView.
Abstract Background Misconceptions can be defined as ‘false, persistent beliefs’ or ‘inaccurate, prior knowledge’ and can influence decision‐making. Objectives To investigate the impact of evidence‐based information on UK horse owners' decision‐making for colic. Study Design Mixed‐methods cross‐sectional study.
K. L. Burrell, G. C. W. England, J. H. Burford, S. L. Freeman   +3 more
wiley   +1 more source

Elimination of Fusobacterium nucleatum With Biomimetic Nanoparticles to Reverse Tumor Immunosuppression and Enhance Colorectal Cancer Therapy

Exploration, EarlyView.
Tumor‐related pathogenic bacteria can affect the treatment efficiency of tumors. Therefore, we have designed a nanoparticle that can accurately target tumor cells and related pathogenic bacteria, reverse the immunosuppressive effect of pathogenic bacteria on tumors, and synergistically enhance tumor treatment efficiency through sonodynamic therapy ...
Mengting Zhou, Jiahao Du, Cheng Li, Yefei Zhu, Kairuo Wang, Keyi Wen, Yuanyuan Zhang, Sy‐Tsong Dean Chueng, Qian Chen, Yang Zhang, Huanlong Qin   +10 more
wiley   +1 more source

Gastroenterite Eosinofílica: Um relato de caso

Clinical and Biomedical Research
Introdução: As Gastroenterites Eosinofílicas (GE) são doenças crônicas imunomediadas caracterizadas histologicamente por um aumento de eosinófilos nas diferentes camadas teciduais do trato gastrointestinal.
Lucas Zambiasi, Alícia Regina Zambiasi, Tomás Zanetti Milani, Marcelo Roque Pegoraro Junior, Pedro Matheus Ferrarin   +4 more
doaj  

Marine Macroalgae as a Safe Healthy Food While Meeting Food Security Challenges Arising From Climate Changes

Food Safety and Health, EarlyView.
Planned harvesting and processing of marine macroalgae could meet future global food needs and mitigate fuel‐originated carbon dioxide responsible for climate change. Microalgal foods are nutritious and safe. The utilization of macroalgae would avoid environmental problems arising from the release of overgrowing macroalgae caused by heatwaves, which ...
Upali Samarajeewa
wiley   +1 more source

Dor pélvica crônica não visceral: tratamento multidisciplinar. Relato de caso

Revista Dor
JUSTIFICATIVA E OBJETIVOS: A prevalência de dor pélvica crônica no sexo feminino é de aproximadamente 4%, similar à prevalência da enxaqueca (2,1%), asma (3,7%) e dor lombar (4,1%).
Telma Regina Mariotto Zakka, Lin Tchia Yeng, Manoel Jacobsen Teixeira, Jefferson Rosi Júnior   +3 more
doaj   +1 more source

Dor em baixo ventre: caso clínico [PDF]

, 2015
Uma paciente vai à consulta solicitando um exame de urina em função de apresentar uma dor abdominal em baixo ...
Linhares, Rogério da Silva, Lutz, Bárbara Heather, Capilheira, Marcelo Fernandes   +2 more
core  

Cancer Risk in Marfan Syndrome: A Swedish Population‐Based Cohort Study

International Journal of Cancer, EarlyView.
The cancer risk in Marfan syndrome, an autosomal dominant connective tissue disorder, largely remains to be explored. In this population‐based matched cohort study of 1544 Swedish patients, the overall cancer risk in adults with Marfan syndrome showed no significant increase, except for the risk of endocrine tumours with a nearly threefold increase ...
Ida Nordgren, Anna Skarin Nordenvall, Alexandra Wachtmeister, Fulya Taylan, Yunxia Lu, Christina Norrby, Anna Lindstrand, Giedre Grigelioniene, Giorgio Tettamanti   +8 more
wiley   +1 more source

DOR ABDOMINAL [PDF]

, 2019
Marcos Paulo Ildefonso, Thaís Aguiar Cunha, Francisco Julimar Correia de Menezes   +2 more
openaire   +1 more source

Avaiação da Dor e da Postura em Pacientes com Lombalgia Submetidos a Dois Protocolos de Fortalecimento Abdominal [PDF]

, 2012
Introduction: the lumbar spine is the main part of the body responsible for the support of the loads, where approximately half of body weight is in stable balance.
Marques, Ana Elisa Zuliani Stroppa, Pedroni, Cristiane Rodrigues, Camargo, Gabriela Machado   +2 more
core