Results 1 to 10 of about 90,937 (252)

TGR5 agonists induce peripheral and central hypersensitivity to bladder distension

Scientific Reports, 2022
The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood.
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley   +6 more
doaj   +1 more source

Visceral pain from neuroanatomy to receptors – focus on gastrointestinal pain [PDF]

Romanian Journal of Neurology, 2016
The mechanisms and nervous structures involved in visceral pain are poorly understood, although visceral pain is one of the most debilitating clinical types of pain.
Teodora Alexa-Stratulat, Andrei Luca, Catalina Roxana Bohotin   +2 more
doaj   +1 more source

Greater interruption of visual processing and memory encoding by visceral than somatic pain in healthy volunteers – An fMRI study

NeuroImage, 2022
Visceral pain is regarded as more salient than somatic pain. It has greater affective and emotional components, i.e., it elicits higher levels of pain-related fear and is perceived as more unpleasant than somatic pain. In this fMRI study, we examined the
Katharina Schmidt, Julian Kleine-Borgmann, Katrin Scharmach, Diana Müssgens, Sigrid Elsenbruch, Ulrike Bingel, Katarina Forkmann   +6 more
doaj   +1 more source

Disengaging spinal afferent nerve communication with the brain in live mice

Communications Biology, 2022
A surgical method in mice can selectively remove dorsal root ganglia (DRG) at specific spinal levels without interfering with other nerves, providing insight on thoracolumbar vs. lumbosacral DRG contributions to pain signalling and behaviour.
Melinda A. Kyloh, Timothy J. Hibberd, Joel Castro, Andrea M. Harrington, Lee Travis, Kelsi N. Dodds, Lukasz Wiklendt, Stuart M. Brierley, Vladimir P. Zagorodnyuk, Nick J. Spencer   +9 more
doaj   +1 more source

Visceral pain: gut microbiota, a new hope?

Journal of Biomedical Science, 2018
Background Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures.
Matteo M Pusceddu, Melanie G Gareau
doaj   +1 more source

NONORGANIC PAIN AND VISCERAL HYPERALGESIA IN CHILDHOOD [PDF]

Romanian Journal of Pediatrics, 2013
Visceral pain is different from the somatic one: visceral receptors have different functional engagement, the nociception degree differ from one organ to another, the few visceral afferent fi bers are predominantly unmyelinised and have an extensive ...
Ileana Ioniuc, Monica Alexoae, Georgiana Russu   +2 more
doaj   +1 more source

Possible implications of animal models for the assessment of visceral pain

Animal Models and Experimental Medicine, 2020
Acute pain, provoked generally after the activation of peripheral nociceptors, is an adaptive sensory function that alerts the individual to avoid noxious stimuli.
Bharata Regmi, Manoj K. Shah
doaj   +1 more source

Animal models of visceral pain and the role of the microbiome

Neurobiology of Pain, 2021
Visceral pain refers to pain arising from the internal organs and is distinctly different from the expression and mechanisms of somatic pain. Diseases and disorders with increased visceral pain are associated with significantly reduced quality of life ...
Christine West, Karen-Anne McVey Neufeld
doaj   +1 more source

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

Brain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu   +5 more
doaj   +1 more source

The locus coeruleus input to the rostral ventromedial medulla mediates stress-induced colorectal visceral pain

Acta Neuropathologica Communications, 2023
Unlike physiological stress, which carries survival value, pathological stress is widespread in modern society and acts as a main risk factor for visceral pain.
Dexu Kong, Yunchun Zhang, Po Gao, Chao Pan, Haoyue Deng, Saihong Xu, Dan Tang, Jie Xiao, Yingfu Jiao, Weifeng Yu, Daxiang Wen   +10 more
doaj   +1 more source