Molecular Mechanisms and Pathways in Visceral Pain [PDF]
CellsChronic visceral pain, a significant contributor to morbidity in the United States, affects millions and results in substantial economic costs. Despite its impact, the mechanisms underlying disorders of gut–brain interaction (DGBIs), such as irritable ...
Qiqi Zhou, George Nicholas Verne
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Possible implications of animal models for the assessment of visceral pain
Animal Models and Experimental Medicine, 2020 Acute pain, provoked generally after the activation of peripheral nociceptors, is an adaptive sensory function that alerts the individual to avoid noxious stimuli.
Bharata Regmi, Manoj K. Shah
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A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation [PDF]
Nature CommunicationsVisceral pain represents an unmet clinical need due to the lack of safe and generalizable therapies. Given the analgesic potential of music and the underlying crosstalk between auditory and nociceptive pathways, this study aims to delineate the neural ...
Yang Yu +7 more
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The enhanced analgesic effects of electroacupuncture and repetitive transcranial magnetic stimulation on visceral pain via ventral lateral septal nucleus [PDF]
Molecular PainIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized primarily by chronic visceral pain, with a complex pathogenesis and limited efficacy of current therapeutic interventions.
Rui-Xia Weng +10 more
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Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice [PDF]
Nature CommunicationsChronic visceral pain is frequently accompanied by changes in food preference. The paraventricular hypothalamus (PVH) and the anterior cingulate cortex (ACC) are well-known regions involved in pain processing and food intake.
Qi-Ya Xu +9 more
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Advances in the pathological mechanisms and clinical treatments of chronic visceral pain [PDF]
Molecular PainChronic visceral pain stems from internal organs and is frequently associated with functional gastrointestinal disorders, like irritable bowel syndrome (IBS). Since the underlying mechanisms of visceral pain remain largely unclear, clinical management is
Yong-Chang Li +9 more
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Costly pain avoidance and its impact on the modulation and extinction of visceral pain-related fear [PDF]
Scientific ReportsAlong the gut-brain axis, visceral pain demonstrably evokes emotional learning and memory processes shaping behavior in clinically relevant ways. Avoidance motivated by learned fear may constitute a major obstacle to treatment success in extinction-based
Franziska Labrenz +3 more
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Upregulation of LRRC8A in the anterior cingulate cortex mediates chronic visceral pain in adult male mice with neonatal maternal deprivation [PDF]
Molecular PainIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder primarily characterized by chronic visceral pain. Studies have reported that the anterior cingulate cortex (ACC) is involved in chronic visceral pain, however, the molecular ...
Jin-Nan Lu +6 more
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Neural circuits regulating visceral pain [PDF]
Communications BiologyVisceral hypersensitivity, a common clinical manifestation of irritable bowel syndrome, may contribute to the development of chronic visceral pain, which is a major challenge for both patients and health providers.
Xiaoli Chang +2 more
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TGR5 agonists induce peripheral and central hypersensitivity to bladder distension
Scientific Reports, 2022 The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood.
Ashlee Caldwell +6 more
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