Results 1 to 10 of about 21,147 (220)

Upregulation of Netrin-1 in the hippocampus mediates the formation of visceral hypersensitivity induced by maternal separation [PDF]

Frontiers in Molecular Neuroscience, 2022
Early adverse life events (EALs), such as maternal separation (MS), can cause visceral hypersensitivity, which is thought to be a key pathophysiological mechanism of irritable bowel syndrome (IBS). Previous studies mainly focused on EALs-induced visceral
Huihui Sun, Shuchang Xu, Sun Huihui
exaly   +5 more sources

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation [PDF]

Brain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu   +5 more
doaj   +4 more sources

Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis [PDF]

Frontiers in Pharmacology, 2023
Background: Irritable bowel syndrome (IBS) is a group of functional intestinal disorders characterized by abdominal pain, bloating, and changes in bowel habits, and/or stool characteristics.
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen   +4 more
doaj   +2 more sources

miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats [PDF]

Molecular Pain
Visceral hypersensitivity is a hallmark feature of irritable bowel syndrome (IBS), yet its underlying mechanisms remain incompletely understood. In the present study, we found that miRNA-let7b5p was downregulated in the spinal cord of IBS model rats ...
Xianhe Wu, Ying Tang, Zhengqing He, Fan Yang, Yiqian Liu, Qianli Zhang, Aiqin Chen, Yu Chen, Chun Lin   +8 more
doaj   +2 more sources

BNSTAVGABA-PVNCRF Circuit Regulates Visceral Hypersensitivity Induced by Maternal Separation in Vgat-Cre Mice

Frontiers in Pharmacology, 2021
Visceral hypersensitivity as a common clinical manifestation of irritable bowel syndrome (IBS) may contribute to the development of chronic visceral pain.
Yong-Mei Zhang, Zhang Yong-Mei
exaly   +3 more sources

Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice [PDF]

Molecular Pain
Background: Visceral hypersensitivity is a prevalent and debilitating symptom in inflammatory bowel disease (IBD), severely impairing quality of life.
Lei Gao, Ruiyu Wang, Jingting Zhou, Shiqin Xu, Shanwu Feng, Liping Zhao, Chunyi Jiang, Xian Wang   +7 more
doaj   +2 more sources

Microglia-mediated BLA glutamatergic neuronal hyperactivity in the BLA-ACC pathway contributes to stress-induced visceral hypersensitivity and anxiety in rats [PDF]

Molecular Medicine
Background Visceral hypersensitivity and anxiety are frequently present as comorbidities in patients with irritable bowel syndrome (IBS). We previously found that both the basolateral amygdala (BLA) and the anterior cingulate cortex (ACC) are involved in
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Ying Chen, Ewan St John Smith, Ying Huang, Shu-Chang Xu   +6 more
doaj   +2 more sources

Visceral hypersensitivity in irritable bowel syndrome [PDF]

Journal of Gastroenterology and Hepatology (Australia), 2011
AbstractAltered central processing, abnormal gastrointestinal motility and visceral hypersensitivity may be possible major pathophysiology of irritable bowel syndrome (IBS). These factors affect each other and are probably associated with development of IBS symptoms.It has been confirmed that lower pain threshold to colonic distention was observed in ...
Motoyori Kanazawa, Shin Fukudo
exaly   +3 more sources

Sympathetic Overactivation Drives Colonic Eosinophil Infiltration Linked to Visceral Hypersensitivity in Irritable Bowel SyndromeSummaryWhat You Need to Know [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Mucosal immune alteration is a characteristic clinical manifestation of irritable bowel syndrome (IBS), and its symptoms are often triggered by psychological stress.
Shaoqi Duan, Hirosato Kanda, Feng Zhu, Masamichi Okubo, Taro Koike, Yoshiya Ohno, Toshiyuki Tanaka, Yukiko Harima, Kazunari Miyamichi, Hirokazu Fukui, Shinichiro Shinzaki, Yilong Cui, Koichi Noguchi, Yi Dai   +13 more
doaj   +2 more sources

Sacral nerve stimulation with optimized parameters improves visceral hypersensitivity in rats mediated via the autonomic pathway

Molecular Pain, 2019
The purpose of this study was to determine effects and mechanisms of sacral nerve stimulation (SNS) on visceral hypersensitivity in rodent models of colonic hypersensitivity.
Liuqin Jiang, Nina Zhang, Shengai Zhang   +2 more
exaly   +2 more sources