Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis [PDF]
Frontiers in Pharmacology, 2023 Background: Irritable bowel syndrome (IBS) is a group of functional intestinal disorders characterized by abdominal pain, bloating, and changes in bowel habits, and/or stool characteristics.
Siyu Tian +4 more
doaj +2 more sources
An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking [PDF]
Advanced ScienceThe comorbidity between irritable bowel syndrome (IBS) and anxiety arises from impaired sensory‐emotional integration, yet its underlying neural circuit mechanisms remain elusive.
Junwen Wang +8 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 Visceral hypersensitivity as a common clinical manifestation of irritable bowel syndrome (IBS) may contribute to the development of chronic visceral pain.
Yong-Mei Zhang, Si-Ting Huang
exaly +3 more sources
miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats [PDF]
Molecular PainVisceral hypersensitivity is a hallmark feature of irritable bowel syndrome (IBS), yet its underlying mechanisms remain incompletely understood. In the present study, we found that miRNA-let7b5p was downregulated in the spinal cord of IBS model rats ...
Xianhe Wu +8 more
doaj +2 more sources
Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice [PDF]
Molecular PainBackground: Visceral hypersensitivity is a prevalent and debilitating symptom in inflammatory bowel disease (IBD), severely impairing quality of life.
Lei Gao +7 more
doaj +2 more sources
Microglia-mediated BLA glutamatergic neuronal hyperactivity in the BLA-ACC pathway contributes to stress-induced visceral hypersensitivity and anxiety in rats [PDF]
Molecular MedicineBackground Visceral hypersensitivity and anxiety are frequently present as comorbidities in patients with irritable bowel syndrome (IBS). We previously found that both the basolateral amygdala (BLA) and the anterior cingulate cortex (ACC) are involved in
Guang-Bing Duan +6 more
doaj +2 more sources
Molecular Pain, 2019 The purpose of this study was to determine effects and mechanisms of sacral nerve stimulation (SNS) on visceral hypersensitivity in rodent models of colonic hypersensitivity.
Liuqin Jiang, Jieyun Yin, Nina Zhang
exaly +2 more sources
Sympathetic Overactivation Drives Colonic Eosinophil Infiltration Linked to Visceral Hypersensitivity in Irritable Bowel SyndromeSummaryWhat You Need to Know [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Mucosal immune alteration is a characteristic clinical manifestation of irritable bowel syndrome (IBS), and its symptoms are often triggered by psychological stress.
Shaoqi Duan +13 more
doaj +2 more sources
Frontiers in Endocrinology, 2022 Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jian-Hua Sun +2 more
exaly +3 more sources
Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility [PDF]
Gut MicrobesThe gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function.
Haonan Zheng +12 more
doaj +2 more sources