Results 1 to 10 of about 19,609 (108)

Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis [PDF]

Frontiers in Pharmacology, 2023
Background: Irritable bowel syndrome (IBS) is a group of functional intestinal disorders characterized by abdominal pain, bloating, and changes in bowel habits, and/or stool characteristics.
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen   +4 more
doaj   +2 more sources

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation [PDF]

Brain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, Li Liu   +5 more
doaj   +2 more sources

miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats [PDF]

Molecular Pain
Visceral hypersensitivity is a hallmark feature of irritable bowel syndrome (IBS), yet its underlying mechanisms remain incompletely understood. In the present study, we found that miRNA-let7b5p was downregulated in the spinal cord of IBS model rats ...
Xianhe Wu, Ying Tang, Zhengqing He, Fan Yang, Yiqian Liu, Qianli Zhang, Aiqin Chen, Yu Chen, Chun Lin   +8 more
doaj   +2 more sources

Copper chelator ammonium tetrathiomolybdate ameliorates the visceral hypersensitivity in dextran sulfate sodium-induced colitis mice [PDF]

Molecular Pain
Background: Visceral hypersensitivity is a prevalent and debilitating symptom in inflammatory bowel disease (IBD), severely impairing quality of life.
Lei Gao, Ruiyu Wang, Jingting Zhou, Shiqin Xu, Shanwu Feng, Liping Zhao, Chunyi Jiang, Xian Wang   +7 more
doaj   +2 more sources

Microglia-mediated BLA glutamatergic neuronal hyperactivity in the BLA-ACC pathway contributes to stress-induced visceral hypersensitivity and anxiety in rats [PDF]

Molecular Medicine
Background Visceral hypersensitivity and anxiety are frequently present as comorbidities in patients with irritable bowel syndrome (IBS). We previously found that both the basolateral amygdala (BLA) and the anterior cingulate cortex (ACC) are involved in
Guang-Bing Duan, Jun-Wen Wang, Hui-Hui Sun, Ying Chen, Ewan St John Smith, Ying Huang, Shu-Chang Xu   +6 more
doaj   +2 more sources

Sympathetic Overactivation Drives Colonic Eosinophil Infiltration Linked to Visceral Hypersensitivity in Irritable Bowel SyndromeSummaryWhat You Need to Know [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Mucosal immune alteration is a characteristic clinical manifestation of irritable bowel syndrome (IBS), and its symptoms are often triggered by psychological stress.
Shaoqi Duan, Hirosato Kanda, Feng Zhu, Masamichi Okubo, Taro Koike, Yoshiya Ohno, Toshiyuki Tanaka, Yukiko Harima, Kazunari Miyamichi, Hirokazu Fukui, Shinichiro Shinzaki, Yilong Cui, Koichi Noguchi, Yi Dai   +13 more
doaj   +2 more sources

Sacral nerve stimulation with optimized parameters improves visceral hypersensitivity in rats mediated via the autonomic pathway

Molecular Pain, 2019
The purpose of this study was to determine effects and mechanisms of sacral nerve stimulation (SNS) on visceral hypersensitivity in rodent models of colonic hypersensitivity.
Liuqin Jiang, Jieyun Yin, Shengai Zhang   +2 more
exaly   +2 more sources

Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility [PDF]

Gut Microbes
The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). The mechanosensory Piezo2 has been implicated in the regulation of intestinal function.
Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan   +12 more
doaj   +2 more sources

The Importance of Visceral Hypersensitivity in Irritable Bowel Syndrome—Plant Metabolites in IBS Treatment [PDF]

Pharmaceuticals, 2023
Robert Sitarz, Monika Sienkiewicz, Andreas Grabrucker   +2 more
exaly   +2 more sources

The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome [PDF]

Frontiers in Neuroscience, 2023
Xu Zhifang, Lin Xiaowei, Wang Yiru
exaly   +2 more sources