Results 21 to 30 of about 184,182 (219)

Peripheral and central mechanisms in acid induced visceral pain hypersensitivity in the human oesophagus [PDF]

open access: yes, 2010
PhDIntroduction: Gastro-oesophageal reflux disease (GORD) affects 40% of Western populations. Many symptoms persist despite the resolution of inflammation or acid exposure.
Chua, Yang Chong
core   +4 more sources

Small-Conductance Ca2+-Activated K+ Channels 2 in the Hypothalamic Paraventricular Nucleus Precipitates Visceral Hypersensitivity Induced by Neonatal Colorectal Distension in Rats

open access: yesFrontiers in Pharmacology, 2021
Visceral hypersensitivity is one of the pivotal pathophysiological features of visceral pain in irritable bowel syndrome (IBS). Small-conductance Ca2+-activated K+ channel (SK) is critical for a variety of functions in the central nervous system (CNS ...
Ning-Ning Ji   +7 more
doaj   +1 more source

Upregulation of Netrin-1 in the hippocampus mediates the formation of visceral hypersensitivity induced by maternal separation

open access: yesFrontiers in Molecular Neuroscience, 2022
Early adverse life events (EALs), such as maternal separation (MS), can cause visceral hypersensitivity, which is thought to be a key pathophysiological mechanism of irritable bowel syndrome (IBS). Previous studies mainly focused on EALs-induced visceral
Junwen Wang   +7 more
doaj   +1 more source

Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome

open access: yesFrontiers in Cellular Neuroscience, 2022
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by recurrent visceral pain and altered bowel habits (diarrhea or constipation). However, the molecular and pathological mechanisms are poorly understood.
Yuan Liu   +10 more
doaj   +1 more source

Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation

open access: yesBrain Sciences, 2023
Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain.
Ziyang Chen   +5 more
doaj   +1 more source

Detection and Evaluation Methods of Visceral Sensitivity in Irritable Bowel Syndrome: a Review of the Latest Developments [PDF]

open access: yesZhongguo quanke yixue, 2023
Visceral hypersensitivity is one major pathophysiological characteristic of irritable bowel syndrome (IBS) , a common functional bowel disorder. The detection and evaluation of visceral hypersensitivity are of practical significance for the guidance of ...
HOU Yujun, ZHAO Ying, JIANG Huiling, TAN Yu, ZHANG Wei, LI Ying, ZHENG Qianhua
doaj   +1 more source

Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity and Anxiety via ACC-AIC Circuit Modulation in IBS Rats. [PDF]

open access: yesNeuropsychiatr Dis Treat
Dan Wang,1 Yixuan Guo,2 Zhichun Wu,3 Haiyan Zhang4 1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People’s Republic of China; 2College of Acupuncture-Moxibustion and Tuina, Shandong
Wang D, Guo Y, Wu Z, Zhang H.
europepmc   +2 more sources

Clostridium butyricum relieve the visceral hypersensitivity in mice induced by Citrobacter rodentium infection with chronic stress [PDF]

open access: yesPeerJ, 2021
Background Visceral hypersensitivity is a common symptom in patients with post-infectious irritable bowel syndrome (PI-IBS), and change of the microbiota is a vital etiological factor of it. Clostridium butyricum (C.
Tengfei Wang   +6 more
doaj   +2 more sources

Gut pain & visceral hypersensitivity [PDF]

open access: yesBritish Journal of Pain, 2013
Visceral pain is a highly complex entity whose experience is variable in health and disease. It can occur in patients with organic disease and also in those without any readily identifiable structural or biochemical abnormality such as in the functional gastrointestinal disorders (FGID).
Adam D, Farmer, Qasim, Aziz
openaire   +2 more sources

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

open access: yesHepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman   +4 more
wiley   +1 more source

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