Results 21 to 30 of about 19,706 (202)

Visceral hypersensitivity: facts, speculations, and challenges [PDF]

open access: yesGut, 2001
Visceral hypersensitivity is currently the holy grail....it is widely regarded as the reason for the development of functional gastrointestinal diseases, including functional dyspepsia and irritable bowel syndrome.1 Although the field has advanced considerably in the past decade, it is necessary to take stock and realistically appraise our current ...
M, Camilleri, B, Coulie, J F, Tack
openaire   +2 more sources

Visceral hypersensitivity in irritable bowel syndrome [PDF]

open access: yesJournal of Gastroenterology and Hepatology, 2011
AbstractAltered central processing, abnormal gastrointestinal motility and visceral hypersensitivity may be possible major pathophysiology of irritable bowel syndrome (IBS). These factors affect each other and are probably associated with development of IBS symptoms.It has been confirmed that lower pain threshold to colonic distention was observed in ...
Motoyori, Kanazawa   +2 more
openaire   +2 more sources

The role of visceral hypersensitivity in the pathogenesis of irritable bowel syndrome

open access: yesТерапевтический архив, 2021
This research includes visceral sensitivity and its mechanisms involved in the development of irritable bowel syndrome. Visceral hypersensitivity occupies the key place.
Alina A. Makarova   +4 more
doaj   +1 more source

Adrenergic β2-receptors mediates visceral hypersensitivity induced by heterotypic intermittent stress in rats. [PDF]

open access: yesPLoS ONE, 2014
Chronic visceral pain in patients with irritable bowel syndrome (IBS) has been difficult to treat effectively partially because its pathophysiology is not fully understood.
Chunhua Zhang   +7 more
doaj   +1 more source

Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral Hypersensitivity in Rats

open access: yesFrontiers in Pharmacology, 2018
Visceral hypersensitivity is a highly complex and subjective phenomenon associated with multiple levels of the nervous system and a wide range of neurotransmission.
Yu Song   +9 more
doaj   +1 more source

Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. [PDF]

open access: yesPLoS ONE, 2016
The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and as a result current therapies are ineffective. The objective of this study was to investigate the effect of spinal protein kinase
Ying Tang   +7 more
doaj   +1 more source

Circadian dysregulation induces alterations of visceral sensitivity and the gut microbiota in Light/Dark phase shift mice

open access: yesFrontiers in Microbiology, 2022
BackgroundIt is well-established that several features of modern lifestyles, such as shift work, jet lag, and using electronics at night, disturb normal circadian rhythm and increase the risk of suffering from functional gastrointestinal disease ...
Lilin Hu   +5 more
doaj   +1 more source

Histone hyperacetylation modulates spinal type II metabotropic glutamate receptor alleviating stress-induced visceral hypersensitivity in female rats

open access: yesMolecular Pain, 2016
Stress is often a trigger to exacerbate chronic pain including visceral hypersensitivity associated with irritable bowel syndrome, a female predominant functional bowel disorder.
Dong-Yuan Cao PhD   +4 more
doaj   +1 more source

Toll-Like Receptor 4 in Paraventricular Nucleus Mediates Visceral Hypersensitivity Induced by Maternal Separation

open access: yesFrontiers in Pharmacology, 2017
Neonatal maternal separation (MS) is a major early life stress that increases the risk of emotional disorders, visceral pain perception and other brain dysfunction.
Hui-Li Tang   +7 more
doaj   +1 more source

Neurotrophin signaling and visceral hypersensitivity [PDF]

open access: yesFrontiers in Biology, 2014
Neurotrophin family are traditionally recognized for their nerve growth promoting function and are recently identified as crucial factors in regulating neuronal activity in the central and peripheral nervous systems. The family members including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) are reported ...
openaire   +2 more sources

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