Results 11 to 20 of about 184,182 (219)

Early‐life adversity, epigenetics, and visceral hypersensitivity [PDF]

Neurogastroenterology & Motility, 2017
AbstractAbdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (IBS), functional dyspepsia, and inflammatory bowel disease (IBD). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders/diseases.
S. Liu, SI. Hagiwara, A. Bhargava
openaire   +6 more sources

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress

Gastroenterology Research and Practice, 2018
Background. Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake ...
Chen Zhao, Mengjuan Lin, Yasi Pan, Baoping Yu   +3 more
doaj   +2 more sources

Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral Hypersensitivity in Rats

Frontiers in Pharmacology, 2018
Visceral hypersensitivity is a highly complex and subjective phenomenon associated with multiple levels of the nervous system and a wide range of neurotransmission.
Yu Song, Jun-Sheng Zhu, Rong Hua, Rong Hua, Lei Du, Si-Ting Huang, Robert W. Stackman, Gongliang Zhang, Gongliang Zhang, Yong-Mei Zhang   +9 more
doaj   +2 more sources

Pathophysiology of stress-induced visceral hypersensitivity [PDF]

, 2014
Visceral hypersensitivity is observed in the majority of patients with IBS and considered a pathophysiological mechanism. The aim of the work described in this thesis was to obtain a better understanding of the stress-related pathophysiology of visceral hypersensitivity. Investigations were carried out in the rat model of maternal separation.
Stanisor, O.I.
core   +8 more sources

Visceral Hypersensitivity Is Not a Feature of Fibromyalgia Syndrome

Journal of Musculoskeletal Pain, 2001
Objective: Visceral hyperalgesia is commonly observed in irritable bowel syndrome [IBS], a common cause of comorbidity with fibromyalgia syndrome [FMS]. The aim of this study was to evaluate in patients affected by FMS the presence of IBS-like symptoms and of visceral hyperalgesia.Methods: Twenty-seven FMS patients were studied and compared with 32 IBS
F. Pace, P. Sarzi-Puttini, G. Manzionna, P. Molteni, M. Turiel, PANNI, BENEDETTA, G. Bianchi Porro   +6 more
openaire   +2 more sources

Zeta Inhibitory Peptide as a Novel Therapy to Control Chronic Visceral Hypersensitivity in a Rat Model. [PDF]

PLoS ONE, 2016
The pathogenesis of multiple chronic visceral pain syndromes, such as irritable bowel syndrome (IBS), is not well known, and as a result current therapies are ineffective. The objective of this study was to investigate the effect of spinal protein kinase
Ying Tang, Aiqin Chen, Yu Chen, Lixia Guo, Hengfen Dai, Yang Huang, Qianqian Chen, Chun Lin   +7 more
doaj   +2 more sources

Visceral hypersensitivity is provoked by 2,4,6-trinitrobenzene sulfonic acid-induced ileitis in rats [PDF]

Frontiers in Pharmacology, 2016
Background and Aims: Crohn’s Disease (CD), a chronic Inflammatory Bowel Disease, can occur in any part of the gastrointestinal tract, but most frequently in the ileum.
Manoj Kumar Shah, Juan Wan, Habibullah Janyaro, Adnan Hassan Tahir, Luying Cui, Ming-Xing Ding   +5 more
doaj   +2 more sources

Serotonergic and non‐serotonergic targets in the pharmacotherapy of visceral hypersensitivity

Neurogastroenterology & Motility, 2007
Abstract  Visceral hypersensitivity is considered a key mechanism in the pathogenesis of functional gastrointestinal (GI) disorders. Targeting visceral hypersensitivity seems an attractive approach to the development of drugs for functional GI disorders. This review summarizes current knowledge on targets for the treatment of visceral hypersensitivity,
BUENO L., DE PONTI, FABRIZIO, FRIED M., KULLAK UBLICK G. A., KWIATEK M. A., POHL D., QUIGLEY E. M. M., TACK J., TALLEY N. J.   +8 more
openaire   +4 more sources

Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model

Journal of Pharmacological Sciences, 2023
Visceral hypersensitivity and leaky gut, which are mediated via corticotropin-releasing factor (CRF) and Toll-like receptor 4 are key pathophysiology of irritable bowel syndrome (IBS). Metformin was reported to improve these gastrointestinal (GI) changes.
Tsukasa Nozu, Saori Miyagishi, Masatomo Ishioh, Kaoru Takakusaki, Toshikatsu Okumura   +4 more
doaj   +2 more sources

Visceral hypersensitivity in functional disorders of the upper gastrointestinal tract

Digestive and Liver Disease, 2004
Visceral hypersensitivity is now recognised as a major pathophysiological mechanism in functional gastrointestinal disorders of the upper gastrointestinal tract. In patients with non-cardiac chest pain and functional dyspepsia, a high prevalence of visceral hypersensitivity has been indeed observed.
G, Sarnelli, J, Vandenberghe, J, Tack
openaire   +4 more sources