Results 31 to 40 of about 19,706 (202)

Reversal of visceral and somatic hypersensitivity in a subset of hypersensitive rats by intracolonic lidocaine [PDF]

Pain, 2008
Chronic abdominal pain is a common gastrointestinal symptom experienced by patients. We have previously shown that IBS patients with visceral hypersensitivity also have evidence of thermal hypersensitivity of the hand and foot that is reversed by rectal lidocaine jelly.
Division of Gastroenterology, Hepatology,, Nutrition, Ohio State University West 12th Avenue, Office Tower 288A, Columbus, OH 43210, USA ( host institution ), Zhou, QiQi, Price, Donald D., Verne, G. Nicholas   +4 more
openaire   +3 more sources

Blockage of High-Affinity Choline Transporter Increases Visceral Hypersensitivity in Rats with Chronic Stress

Gastroenterology Research and Practice, 2018
Background. Visceral hypersensitivity is a common feature of irritable bowel syndrome. Cholinergic system involves in the development of visceral hypersensitivity, and high-affinity choline transporter (CHT1) is of crucial importance in choline uptake ...
Chen Zhao, Mengjuan Lin, Yasi Pan, Baoping Yu   +3 more
doaj   +1 more source

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

Frontiers in Endocrinology, 2022
Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jing Guo, Jing Guo, Lu Chen, Yu-hang Wang, Ya-fang Song, Zhan-hao Zhao, Ting-ting Zhao, Zhi-ying Lin, Dong-mei Gu, Yun-qi Liu, Yong-jun Peng, Li-xia Pei, Jian-hua Sun   +12 more
doaj   +1 more source

Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model

Molecular Pain, 2021
Background Visceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abdominal pain is the most common symptoms in IBS patients.
F Fan, Y Chen, Z Chen, L Guan, Z Ye, Y Tang, A Chen, C Lin   +7 more
doaj   +1 more source

Aluminum Ingestion Promotes Colorectal Hypersensitivity in RodentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known.
Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel   +9 more
doaj   +1 more source

Early‐life adversity, epigenetics, and visceral hypersensitivity [PDF]

Neurogastroenterology & Motility, 2017
AbstractAbdominal pain is associated with many gastrointestinal dysfunctions, such as irritable bowel syndrome (IBS), functional dyspepsia, and inflammatory bowel disease (IBD). Visceral hypersensitivity is a key reason for development of abdominal pain that presents in these gastrointestinal disorders/diseases.
S. Liu, SI. Hagiwara, A. Bhargava
openaire   +4 more sources

Visceral hypersensitivity in endometriosis: a new target for treatment? [PDF]

Gut, 2011
Objective In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy.
Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S.; id_orcid 0000-0001-9640-7427, Whorwell, P. J.; id_orcid 0000-0002-5220-8474   +6 more
openaire   +3 more sources

Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Molecular Pain, 2022
Background : Accumulating evidence shows that N6 -methyladenosine (m 6 A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m 6 A writers involved in visceral hypersensitivity of Irritable bowel syndrome (IBS) remain ...
Wei Lin, Yuan Liu, Yifei Zhou, Mengying Lin, Congxu Liu, Ying Tang, Bin Wu, Chun Lin   +7 more
doaj   +1 more source

Visceral pain hypersensitivity in functional gastrointestinal disorders [PDF]

British Medical Bulletin, 2009
Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders whose diagnostic criteria are symptom based in the absence of a demonstrable structural or biochemical abnormality. Chronic abdominal pain or discomfort is a defining characteristic of these disorders and a proportion of patients may display heightened
A D, Farmer, Q, Aziz
openaire   +2 more sources

Visceral hypersensitivity is provoked by 2,4,6-trinitrobenzene sulfonic acid-induced ileitis in rats

Frontiers in Pharmacology, 2016
Background and Aims: Crohn’s Disease (CD), a chronic Inflammatory Bowel Disease, can occur in any part of the gastrointestinal tract, but most frequently in the ileum.
Manoj Kumar Shah, Juan Wan, Habibullah Janyaro, Adnan Hassan Tahir, Luying Cui, Ming-Xing Ding   +5 more
doaj   +1 more source