Results 41 to 50 of about 21,147 (220)

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis

Frontiers in Endocrinology, 2022
Electroacupuncture (EA) is considered to have a therapeutic effect in the relief of irritable bowel syndrome (IBS)-associated visceral hypersensitivity via the reduction of the level of 5‐hydroxytryptamine (5‐HT) and 5-HT3 receptors (5-HT3R).
Jing Guo, Jing Guo, Lu Chen, Yu-hang Wang, Ya-fang Song, Zhan-hao Zhao, Ting-ting Zhao, Zhi-ying Lin, Dong-mei Gu, Yun-qi Liu, Yong-jun Peng, Li-xia Pei, Jian-hua Sun   +12 more
doaj   +1 more source

Age-related alteration of arginase activity impacts on severity of leishmaniasis. [PDF]

, 2008
BACKGROUND: The leishmaniases are a group of vector-borne parasitic diseases that represent a major international public health problem; they belong to the most neglected tropical diseases and have one of the highest rates of morbidity and mortality. The
Asrat Hailu, Choi, B., Abebe, T, Munder, Markus, Choi, B-S, Abebe Tamrat, Modolell, M, Choi Beak-San, Manuel Modolell, Hailu, A, Abebe, T., Fuentes, J., Modolell Manuel, Kropf Pascale, Abebe, Tamrat, Munder, M, Ingrid Müller, Kropf, P, Müller, Ingrid, Markus Munder, Modolell, M., Munder, M., Kropf, P., Kropf, Pascale, Beak-San Choi, Hailu, A., Fuentes, Jose M, Munder Markus, Fuentes Jose M., Pascale Kropf, Muller, I, Fuentes, JM, Jose M. Fuentes, Müller Ingrid, Jose M Fuentes, Hailu Asrat, Choi, Beak-San, Hailu, Asrat, Modolell, Manuel, Müller, I., Tamrat Abebe   +40 more
core   +1 more source

Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease [PDF]

Gastroenterology Research and Practice, 2022
Nonerosive reflux disease (NERD) is the most common type of gastroesophageal reflux disease (GERD). Its clinical symptoms can recur, and clinical treatment is often ineffective, causing patients severe economic and psychological burden. In recent years, studies that have explored in-depth the pathogenesis of NERD have found that visceral ...
Cao Xu, Xiaoping Niu
openaire   +3 more sources

Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model

Molecular Pain, 2021
Background Visceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abdominal pain is the most common symptoms in IBS patients.
F Fan, Y Chen, Z Chen, L Guan, Z Ye, Y Tang, A Chen, C Lin   +7 more
doaj   +1 more source

Visceral hypersensitivity in endometriosis: a new target for treatment? [PDF]

Gut, 2011
Objective In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy.
Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S.; id_orcid 0000-0001-9640-7427, Whorwell, P. J.; id_orcid 0000-0002-5220-8474   +6 more
openaire   +3 more sources

Aluminum Ingestion Promotes Colorectal Hypersensitivity in RodentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known.
Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel   +9 more
doaj   +1 more source

Visceral pain hypersensitivity in functional gastrointestinal disorders [PDF]

British Medical Bulletin, 2009
Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders whose diagnostic criteria are symptom based in the absence of a demonstrable structural or biochemical abnormality. Chronic abdominal pain or discomfort is a defining characteristic of these disorders and a proportion of patients may display heightened
A D, Farmer, Q, Aziz
openaire   +2 more sources

Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Molecular Pain, 2022
Background : Accumulating evidence shows that N6 -methyladenosine (m 6 A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m 6 A writers involved in visceral hypersensitivity of Irritable bowel syndrome (IBS) remain ...
Wei Lin, Yuan Liu, Yifei Zhou, Mengying Lin, Congxu Liu, Ying Tang, Bin Wu, Chun Lin   +7 more
doaj   +1 more source

Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancement via 5-HT1A receptors in the anterior cingulate cortex in rats

Frontiers in Cellular Neuroscience, 2022
Tandospirone, a third-generation of antianxiety agent with fewer side effects, has been widely used in the treatment of anxiety. Moreover, it is interesting that tandospirone has been found to relieve gastrointestinal symptoms in patients with refractory
Ting-Ting Zhan, Zhi-Yu Dong, Li-Sha Yi, Yan Zhang, Hui-Hui Sun, Hai-Qin Zhang, Jun-Wen Wang, Ying Chen, Ying Huang, Shu-Chang Xu   +9 more
doaj   +1 more source

NaV1.1 inhibition can reduce visceral hypersensitivity [PDF]

JCI Insight, 2018
Functional bowel disorder patients can suffer from chronic abdominal pain, likely due to visceral hypersensitivity to mechanical stimuli. As there is only a limited understanding of the basis of chronic visceral hypersensitivity (CVH), drug-based management strategies are ill defined, vary considerably, and include NSAIDs, opioids,
Juan Salvatierra, Joel Castro, Andelain Erickson, Qian Li, Joao Braz, John Gilchrist, Luke Grundy, Grigori Y. Rychkov, Annemie Deiteren, Rana Rais, Glenn F. King, Barbara S. Slusher, Allan Basbaum, Pankaj J. Pasricha, Stuart M. Brierley, Frank Bosmans   +15 more
openaire   +6 more sources