Results 41 to 50 of about 184,182 (219)

Reversal of visceral and somatic hypersensitivity in a subset of hypersensitive rats by intracolonic lidocaine [PDF]

Pain, 2008
Chronic abdominal pain is a common gastrointestinal symptom experienced by patients. We have previously shown that IBS patients with visceral hypersensitivity also have evidence of thermal hypersensitivity of the hand and foot that is reversed by rectal lidocaine jelly.
Division of Gastroenterology, Hepatology,, Nutrition, Ohio State University West 12th Avenue, Office Tower 288A, Columbus, OH 43210, USA ( host institution ), Zhou, QiQi, Price, Donald D., Verne, G. Nicholas   +4 more
openaire   +3 more sources

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

Angewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng, Ya‐Kun Wang, Ze‐Xin Chen, Yi‐Wen Meng, Meng‐Ting She, Jia‐Peng Dong, Yingying Zheng, Yao‐Xun Zeng, Wen‐De Zheng, Wei Long, Wing‐Leung Wong   +10 more
wiley   +2 more sources

Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease [PDF]

Gastroenterology Research and Practice, 2022
Nonerosive reflux disease (NERD) is the most common type of gastroesophageal reflux disease (GERD). Its clinical symptoms can recur, and clinical treatment is often ineffective, causing patients severe economic and psychological burden. In recent years, studies that have explored in-depth the pathogenesis of NERD have found that visceral ...
Cao Xu, Xiaoping Niu
openaire   +3 more sources

Aluminum Ingestion Promotes Colorectal Hypersensitivity in RodentsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2019
Background & Aims: Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known.
Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel   +9 more
doaj   +1 more source

Beta 3‐adrenoceptor agonism ameliorates early‐life stress‐induced visceral hypersensitivity in male rats [PDF]

, 2023
Visceral hypersensitivity, a hallmark of disorders of the gut-brain axis, is associated with exposure to early-life stress (ELS). Activation of neuronal β3-adrenoceptors (AR) has been shown to alter central and peripheral levels of tryptophan and reduce ...
Marcela Julio‐Pieper, James M. Collins, Gerard Clarke, Patrick Fitzgerald, John F. Cryan, David C. Bulmer, Siobhain M. O'Mahony, Timothy G. Dinan, Niall P. Hyland   +8 more
core   +2 more sources

Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model

Molecular Pain, 2021
Background Visceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abdominal pain is the most common symptoms in IBS patients.
F Fan, Y Chen, Z Chen, L Guan, Z Ye, Y Tang, A Chen, C Lin   +7 more
doaj   +1 more source

Visceral hypersensitivity in endometriosis: a new target for treatment? [PDF]

Gut, 2011
Objective In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed to endometriosis irrespective of whether it is found to be minimal or extensive at laparoscopy.
Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S.; id_orcid 0000-0001-9640-7427, Whorwell, P. J.; id_orcid 0000-0002-5220-8474   +6 more
openaire   +3 more sources

Visceral pain hypersensitivity in functional gastrointestinal disorders [PDF]

British Medical Bulletin, 2009
Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders whose diagnostic criteria are symptom based in the absence of a demonstrable structural or biochemical abnormality. Chronic abdominal pain or discomfort is a defining characteristic of these disorders and a proportion of patients may display heightened
A D, Farmer, Q, Aziz
openaire   +2 more sources

Tandospirone prevents stress-induced anxiety-like behavior and visceral hypersensitivity by suppressing theta oscillation enhancement via 5-HT1A receptors in the anterior cingulate cortex in rats

Frontiers in Cellular Neuroscience, 2022
Tandospirone, a third-generation of antianxiety agent with fewer side effects, has been widely used in the treatment of anxiety. Moreover, it is interesting that tandospirone has been found to relieve gastrointestinal symptoms in patients with refractory
Ting-Ting Zhan, Zhi-Yu Dong, Li-Sha Yi, Yan Zhang, Hui-Hui Sun, Hai-Qin Zhang, Jun-Wen Wang, Ying Chen, Ying Huang, Shu-Chang Xu   +9 more
doaj   +1 more source

An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation. [PDF]

Clin Exp Gastroenterol
Prashant Singh,1 Gregory S Sayuk,2 David P Rosenbaum,3 Susan Edelstein,3 Kenji Kozuka,3 Lin Chang4 1Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; 2Department of Medicine, Washington University School of Medicine, St Louis ...
Singh P, Sayuk GS, Rosenbaum DP, Edelstein S, Kozuka K, Chang L.   +5 more
europepmc   +2 more sources