Results 51 to 60 of about 19,706 (202)

Antinociceptive effect of berberine on visceral hypersensitivity in rats

World Journal of Gastroenterology, 2013
To assess the protective effect of berberine administration and the role of nitric oxide (NO) in visceral hypersensitivity.Fifty male Sprague-Dawley rats were randomly assigned to five groups. An inflammatory bowel disease model was induced in rats by intracolonic instillation of 1 mL 4% acetic acid at 8 cm proximal to the anus for 30 s and restraint ...
Tang, Qing-Lin, Lai, Min-Ling, Zhong, Yuan-Fu, Wang, Ai-Min, Su, Jun-Kai, Zhang, Ming-Qing   +5 more
openaire   +3 more sources

Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients

Journal of Pharmacological Sciences, 2015
It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain.
Yasuo Itomi, Toru Kawamura, Yasuhiro Tsukimi   +2 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity

Biomolecules, 2023
Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood.
Jonathon L. McClain, Wilmarie Morales-Soto, Jacques Gonzales, Visha Parmar, Elena Y. Demireva, Brian D. Gulbransen   +5 more
doaj   +1 more source

Histamine antagonism and postinflammatory visceral hypersensitivity

Gut, 2014
Abdominal pain is one of the most difficult to treat symptoms in patients suffering from IBS. Recent evidence shows that abnormal perception of visceral stimuli, or visceral hypersensitivity, represents an important underlying mechanism. Of interest, similar mechanisms may be involved in abdominal pain reported by UC and Crohn's disease patients in ...
openaire   +3 more sources

Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain

Neurogastroenterology & Motility, 2023
AbstractBackgroundMonosodium glutamate (MSG) has been identified as a trigger of abdominal pain in irritable bowel syndrome (IBS), but the mechanism is unknown. This study examined whether MSG causes visceral hypersensitivity using a water‐avoidance stress (WAS) mouse model of visceral pain.MethodsMice were divided into four groups receiving treatment ...
Bailey J. A. Brant, Yang Yu, Amal Abu Omar, Josue O. Jaramillo Polanco, Cintya D. Lopez Lopez, Nestor N. Jiménez Vargas, Quentin Tsang, Abby McDonell, Kaede Takami, David E. Reed, Alan E. Lomax, Stephen J. Vanner, Caroline J. Tuck   +12 more
openaire   +3 more sources

Low‐FODMAP diet for pediatric patients with disorders of gut‐brain interaction: A systematic review and meta‐analysis

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Objectives The role of a low‐FODMAP diet in pediatric disorders of gut–brain interaction (DGBIs), particularly irritable bowel syndrome (IBS) and functional abdominal pain (FAP), is unclear. This review synthesized evidence on its efficacy in children and adolescents with IBS or FAP.
Pedro Henrique Silva de Oliveira Souza, João Ricardo Coutinho Coêlho, Alexandre Machado de Andrade, Kauã Santana Marques, Vitor Engrácia Valenti, Fabrício dos Santos Menezes, Natascha Silva Sandy   +6 more
wiley   +1 more source

Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple   +3 more
wiley   +1 more source

Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission

Frontiers in Neuroscience, 2022
Inflammatory bowel disease (IBD), comprising Crohn’s disease and Ulcerative colitis, is a relapsing and remitting disease of the gastrointestinal tract, presenting with chronic inflammation, ulceration, gastrointestinal bleeding, and abdominal pain.
Adam Shute, Dominique G. Bihan, Ian A. Lewis, Yasmin Nasser   +3 more
doaj   +1 more source

Feasibility and efficacy of fecal microbiota transplantation in adolescents with refractory irritable bowel syndrome: A randomized clinical pilot trial

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To assess the feasibility and efficacy of fecal microbiota transplantation (FMT) in adolescents (16–21 years) with refractory irritable bowel syndrome (IBS). Methods Randomized controlled pilot trial. Thirty‐two patients were included and randomized to receive two allogeneic or autologous FMTs.
Clara M. A. de Bruijn, Anna O. J. Oorthuys, Judith Zeevenhooven, Mark Davids, Johannes H. M. Levels, Arine M. Vlieger, Hilde Herrema, Max Nieuwdorp, Marc A. Benninga   +8 more
wiley   +1 more source