Results 51 to 60 of about 184,182 (219)

Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner

Molecular Pain, 2022
Background : Accumulating evidence shows that N6 -methyladenosine (m 6 A) modulators contribute to the process of chronic pain. However, the exact mechanisms of m 6 A writers involved in visceral hypersensitivity of Irritable bowel syndrome (IBS) remain ...
Wei Lin, Yuan Liu, Yifei Zhou, Mengying Lin, Congxu Liu, Ying Tang, Bin Wu, Chun Lin   +7 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity

Frontiers in Pharmacology, 2017
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and alteration of bowel movements. The pathogenesis of visceral hypersensitivity in IBS patients remains largely unknown.
Liting Zhao, Ying Xiao, Rui-Xia Weng, Xuelian Liu, Ping-An Zhang, Chuang-Ying Hu, Shan P. Yu, Guang-Yin Xu   +7 more
doaj   +1 more source

Antinociceptive effect of berberine on visceral hypersensitivity in rats

World Journal of Gastroenterology, 2013
To assess the protective effect of berberine administration and the role of nitric oxide (NO) in visceral hypersensitivity.Fifty male Sprague-Dawley rats were randomly assigned to five groups. An inflammatory bowel disease model was induced in rats by intracolonic instillation of 1 mL 4% acetic acid at 8 cm proximal to the anus for 30 s and restraint ...
Tang, Qing-Lin, Lai, Min-Ling, Zhong, Yuan-Fu, Wang, Ai-Min, Su, Jun-Kai, Zhang, Ming-Qing   +5 more
openaire   +3 more sources

NaV1.1 inhibition can reduce visceral hypersensitivity [PDF]

JCI Insight, 2018
Functional bowel disorder patients can suffer from chronic abdominal pain, likely due to visceral hypersensitivity to mechanical stimuli. As there is only a limited understanding of the basis of chronic visceral hypersensitivity (CVH), drug-based management strategies are ill defined, vary considerably, and include NSAIDs, opioids,
Juan Salvatierra, Joel Castro, Andelain Erickson, Qian Li, Joao Braz, John Gilchrist, Luke Grundy, Grigori Y. Rychkov, Annemie Deiteren, Rana Rais, Glenn F. King, Barbara S. Slusher, Allan Basbaum, Pankaj J. Pasricha, Stuart M. Brierley, Frank Bosmans   +15 more
openaire   +6 more sources

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice

Neural Plasticity, 2020
Background. Visceral hypersensitivity is a common occurrence of gastrointestinal diseases such as irritable bowel syndrome (IBS), wherein early-life stress (ELS) may have a high predisposition to the development of visceral hypersensitivity in adulthood,
Ke Wu, Jing-hua Gao, Rong Hua, Xiao-han Peng, Hui Wang, Yong-mei Zhang   +5 more
doaj   +1 more source

Fecal Microbiota Transplantation Is Effective in Relieving Visceral Hypersensitivity in a Postinfectious Model [PDF]

, 2018
Aim. To investigate the effect of fecal microbiota transplantation on visceral hypersensitivity compared withBifidobacterium longum.Methods. Mice visceral hypersensitivity was induced byTrichinella spiralis.
Tao Bai, Xiaohua Hou, Lei Zhang, Wei Qian, Jun Song, Huan Wang   +5 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Maternal Separation Induced Visceral Hypersensitivity Evaluated via Novel and Small Size Distention Balloon in Post-weaning Mice

Frontiers in Neuroscience, 2022
Early life stress (ELS) disposes to functional gastrointestinal diseases in adult, such as irritable bowel syndrome (IBS). Maternal separation (MS) is a well-known animal model of IBS and has been shown to induce visceral hypersensitivity in adult rats ...
Enfu Tao, Enfu Tao, Gao Long, Ting Yang, Bo Chen, Rui Guo, Diya Ye, Marong Fang, Mizu Jiang   +8 more
doaj   +1 more source