Results 61 to 70 of about 19,706 (202)

Outcomes of surgical versus conservative treatment in pediatric median arcuate ligament syndrome

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Median arcuate ligament syndrome (MALS) involves compression of the celiac artery and presents with gastrointestinal symptoms. We evaluated outcomes after surgical versus conservative management in pediatric MALS. Methods We reviewed charts of symptomatic patients aged 7–21 years diagnosed by ultrasound and/or computed tomography ...
Mohamad Abi Nassif, Juan Gurria, Danny Mallon, Rashmi Sahay, Lev Dorfman, Emily Vore, Jennifer Hardy, Kaitlin Whaley, Alex Nasr, Neha R. Santucci   +9 more
wiley   +1 more source

Estrogen-dependent visceral hypersensitivity following stress in rats

Molecular Pain, 2016
We used functional MRI and a longitudinal design to investigate the brain mechanisms in a previously reported estrogen-dependent visceral hypersensitivity model. We hypothesized that noxious visceral stimulation would be associated with activation of the
Catherine S Hubbard PhD, Jane M Karpowicz BS, Andrew J Furman MS, Joyce Teixeira da Silva BS, David A Seminowicz PhD, Richard J Traub PhD   +5 more
doaj   +1 more source

Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation

Molecular Pain, 2020
Background Irritable bowel syndrome is one of the most common gastrointestinal disorders. It is featured by abdominal pain in conjunction with altered bowel habits. However, the pathophysiology of the syndrome remains largely unknown.
Rui-Xia Weng, Wei Chen, Jia-Ni Tang, Qian Sun, Meng Li, Xue Xu, Ping-An Zhang, Ying Zhang, Chuang-Ying Hu, Guang-Yin Xu   +9 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

The Role of Repetitive Transcranial Magnetic Stimulation in Modulating Autonomic Dysfunction in Irritable Bowel Syndrome rTMS for IBS Autonomic Dysfunction

Sensory Neuroscience, EarlyView.
Irritable bowel syndrome (IBS) is associated with dysregulation of the autonomic nervous system and altered brain–gut communication. rTMS may alleviate IBS symptoms by modulating central autonomic and pain‐processing networks, potentially restoring sympathovagal balance and reducing visceral hypersensitivity.
Aliasghar Karimi, Habib Zakeri, Mohammad Radmehr, Saba Moalemi, Pegah Pedramfard   +4 more
wiley   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

New insights into visceral hypersensitivity—clinical implications in IBS [PDF]

Nature Reviews Gastroenterology & Hepatology, 2011
A subset of patients with IBS have visceral hypersensitivity and/or somatic hypersensitivity. Visceral hypersensitivity might have use as a clinical marker of IBS and could account for symptoms of urgency for bowel movements, bloating and abdominal pain. The mechanisms that lead to chronic visceral hypersensitivity in patients who have IBS are unclear.
QiQi, Zhou, G Nicholas, Verne
openaire   +2 more sources

NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity

Molecular Pain, 2009
Background Visceral hypersensitivity is a clinical observation made when diagnosing patients with functional bowel disorders. The cause of visceral hypersensitivity is unknown but is thought to be attributed to inflammation.
Caudle Robert M, Suckow Shelby K
doaj   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

Patient and physician satisfaction with video consultations in dermatology: An exploratory cross‐sectional study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Teledermatology has become an essential part of dermatological care, although challenges in its implementation remain. We conducted a real‐life survey on video consultations over a one‐year period to assess satisfaction and identify barriers.
Felix von Krogh, Julia Zarnowski, Regina Treudler, Jan‐Christoph Simon, Anna‐Theresa Seitz   +4 more
wiley   +1 more source