Results 61 to 70 of about 21,147 (220)
Journal of Pharmacological Sciences, 2023 Visceral hypersensitivity and leaky gut, which are mediated via corticotropin-releasing factor (CRF) and Toll-like receptor 4 are key pathophysiology of irritable bowel syndrome (IBS). Metformin was reported to improve these gastrointestinal (GI) changes.
Tsukasa Nozu +4 more
doaj +1 more source
Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends
Flavour and Fragrance Journal, EarlyView.This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley +1 more source
The Roads of Rome for Functional Dyspepsia: From Rome I to Rome V
Gut Medicine, EarlyView.ABSTRACT Functional dyspepsia (FD) is one of the most common functional gastrointestinal disorders. Its diagnostic, classificatory, and therapeutic concepts have continuously evolved alongside successive iterations of the Rome diagnostic criteria, undergoing profound changes over more than three decades.
Zi‐xing Qian, Wei Wei
wiley +1 more source
Human psychophysiological responses to visceral and somatic pain – the development of integrated, reproducible human pain phenotypes [PDF]
, 2011 PhDBackground Pain is the ubiquitous human experience, yet displays considerable inter- and intraindividual variability in health and disease. Many factors have been proposed to account for these differences.
Farmer, Adam Donald
core
Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome
Gut Medicine, EarlyView.ABSTRACT Gut microbiota and their metabolites have been proposed as possible etiological factors in irritable bowel syndrome (IBS), and studies suggest that IBS is associated with impaired serotonin synthesis and release. Microbial metabolites are produced through biological pathways and enzymatic processes via gut microbiota.
Ning Gao +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2015 It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain.
Yasuo Itomi +2 more
doaj +1 more source
Frontiers in Neuroscience, 2022 Early life stress (ELS) disposes to functional gastrointestinal diseases in adult, such as irritable bowel syndrome (IBS). Maternal separation (MS) is a well-known animal model of IBS and has been shown to induce visceral hypersensitivity in adult rats ...
Enfu Tao +8 more
doaj +1 more source
Histamine antagonism and postinflammatory visceral hypersensitivity
Gut, 2014 Abdominal pain is one of the most difficult to treat symptoms in patients suffering from IBS. Recent evidence shows that abnormal perception of visceral stimuli, or visceral hypersensitivity, represents an important underlying mechanism. Of interest, similar mechanisms may be involved in abdominal pain reported by UC and Crohn's disease patients in ...
openaire +3 more sources
Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain
Neurogastroenterology & Motility, 2023 AbstractBackgroundMonosodium glutamate (MSG) has been identified as a trigger of abdominal pain in irritable bowel syndrome (IBS), but the mechanism is unknown. This study examined whether MSG causes visceral hypersensitivity using a water‐avoidance stress (WAS) mouse model of visceral pain.MethodsMice were divided into four groups receiving treatment ...
Bailey J. A. Brant +12 more
openaire +3 more sources
Biomolecules, 2023 Histamine is a neuromodulator that affects gut motility and visceral sensitivity through intrinsic and extrinsic neural pathways, yet the mechanisms regulating histamine availability in these pathways remain poorly understood.
Jonathon L. McClain +5 more
doaj +1 more source