Results 71 to 80 of about 21,147 (220)

Menthacarin treatment attenuates nociception in models of visceral hypersensitivity. [PDF]

open access articleBackground: Chronic visceral hypersensitivity is closely associated with irritable bowel syndrome (IBS), a very common disorder which significantly impairs quality of life, characterized by abdominal pain, and distension.
Lehner, Martin D., Gronier, Benjamin, Omoloye, Adesina, Weisenburger, Sabrina   +3 more
core   +1 more source

Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats [PDF]

, 2017
BACKGROUND & AIMS: Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the ...
Schuren, F.H.J., Matteo Fornai, Masclee, A.A., Fornai, M., Sigrid E.M. Heinsbroek, Levin, Evgeni, Jonkers, Daisy M., Jonkers, Daisy M, de Jonge, Wouter J, Wouter J. de Jonge, de Weerd, Heleen H., Schuren, Frank H. J., Welting, O., Jonkers, D.M., de Jonge, W.J., Olaf Welting, Teun Boekhout, Evgeni Levin, J. de Jonge, Wouter, Sara Botschuijver, Daisy M. Jonkers, FORNAI, MATTEO, Seppen, Jurgen, A. Masclee, Ad, H. de Weerd, Heleen, Heleen H. de Weerd, Seppen, J., Weerd, H.H. de, Boekhout, Teun, Wijngaard, R.M. van den, Frank H.J. Schuren, Roeselers, Guus, H.J. Schuren, Frank, Seppen, J.; id_orcid, Heinsbroek, Sigrid, Jonge, W.J. de, Levin, E., Heinsbroek, Sigrid Em, Schuren, Frank H. J, Welting, Olaf, Roeselers, G., Masclee, Ad A., Botschuijver, Sara, van den Wijngaard, Rene, M. Jonkers, Daisy, Guus Roeselers, de Weerd, H.H., Heinsbroek, Sigrid E. M., Botschuijver, S., René M. van den Wijngaard, de Jonge, Wouter J., Heinsbroek, S., van den Wijngaard, R.M., Ad A. Masclee, Boekhout, T., Jurgen Seppen, de Weerd, Heleen H, van den Wijngaard, Rene M., Masclee, Ad A, Heinsbroek, S.E.M.   +59 more
core   +1 more source

Feasibility and efficacy of fecal microbiota transplantation in adolescents with refractory irritable bowel syndrome: A randomized clinical pilot trial

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives To assess the feasibility and efficacy of fecal microbiota transplantation (FMT) in adolescents (16–21 years) with refractory irritable bowel syndrome (IBS). Methods Randomized controlled pilot trial. Thirty‐two patients were included and randomized to receive two allogeneic or autologous FMTs.
Clara M. A. de Bruijn, Anna O. J. Oorthuys, Judith Zeevenhooven, Mark Davids, Johannes H. M. Levels, Arine M. Vlieger, Hilde Herrema, Max Nieuwdorp, Marc A. Benninga   +8 more
wiley   +1 more source

Metabolomics: The Key to Unraveling the Role of the Microbiome in Visceral Pain Neurotransmission

Frontiers in Neuroscience, 2022
Inflammatory bowel disease (IBD), comprising Crohn’s disease and Ulcerative colitis, is a relapsing and remitting disease of the gastrointestinal tract, presenting with chronic inflammation, ulceration, gastrointestinal bleeding, and abdominal pain.
Adam Shute, Dominique G. Bihan, Ian A. Lewis, Yasmin Nasser   +3 more
doaj   +1 more source

Outcomes of surgical versus conservative treatment in pediatric median arcuate ligament syndrome

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Median arcuate ligament syndrome (MALS) involves compression of the celiac artery and presents with gastrointestinal symptoms. We evaluated outcomes after surgical versus conservative management in pediatric MALS. Methods We reviewed charts of symptomatic patients aged 7–21 years diagnosed by ultrasound and/or computed tomography ...
Mohamad Abi Nassif, Juan Gurria, Danny Mallon, Rashmi Sahay, Lev Dorfman, Emily Vore, Jennifer Hardy, Kaitlin Whaley, Alex Nasr, Neha R. Santucci   +9 more
wiley   +1 more source

Congenitally elevated gut permeability is linked to basal visceral hyposensitivity but stress-induced visceral hypersensitivity in CA-MLCK mice [PDF]

, 2016
Congenitally elevated gut permeability is linked to basal visceral hyposensitivity but stress-induced visceral hypersensitivity in CA-MLCK mice.
Lévêque, Mathilde, Róka, Richárd, Ferrier, Laurent, Inczefi, Orsolya, Eutamène, Hélène, Wittmann, Tibor, Bétoulières, Colette, Theodorou, Vassilia, Turner, Jerrold R   +8 more
core   +4 more sources

Functional constipation in children and young adults with Prader–Willi syndrome

JPGN Reports, EarlyView.
Abstract Objectives Prader–Willi Syndrome (PWS) is characterized by hyperphagia, endocrinopathies, and gastrointestinal abnormalities. Clinical concerns about constipation and fecal incontinence (FI) are common, but no studies to date have clear data on functional defecation disorders in children with PWS.
Melinda J. Pierce, Isabella Niu, Lusine Ambartsumyan, Parisa Salehi   +3 more
wiley   +1 more source

Estrogen-dependent visceral hypersensitivity following stress in rats

Molecular Pain, 2016
We used functional MRI and a longitudinal design to investigate the brain mechanisms in a previously reported estrogen-dependent visceral hypersensitivity model. We hypothesized that noxious visceral stimulation would be associated with activation of the
Catherine S Hubbard PhD, Jane M Karpowicz BS, Andrew J Furman MS, Joyce Teixeira da Silva BS, David A Seminowicz PhD, Richard J Traub PhD   +5 more
doaj   +1 more source

Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation

Molecular Pain, 2020
Background Irritable bowel syndrome is one of the most common gastrointestinal disorders. It is featured by abdominal pain in conjunction with altered bowel habits. However, the pathophysiology of the syndrome remains largely unknown.
Rui-Xia Weng, Wei Chen, Jia-Ni Tang, Qian Sun, Meng Li, Xue Xu, Ping-An Zhang, Ying Zhang, Chuang-Ying Hu, Guang-Yin Xu   +9 more
doaj   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source