Results 71 to 80 of about 184,182 (219)

Chronic High‐Dose Ketamine Fails to Induce a Cystitis‐Like Phenotype in Mice Despite High Urinary Metabolite Levels

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims Ketamine‑induced cystitis (KIC) is a severe complication of chronic ketamine misuse, yet the underlying mechanisms remain poorly understood. Established rodent models have demonstrated variable changes in voiding behavior and bladder histology, without exploring the sensory mechanisms underlying altered voiding and pain at all. This study
Jill Dewez, Ashlee Caldwell, Laura Schillebeeckx, Margot De Vis, Sylvia João Poseiro Coutinho Pinto, Evy Van Den Broek, Véronique Hendrickx, Katrien Luyten, Marcella Baldewijns, Jan Tytgat, Thomas Voets, Wouter Everaerts   +11 more
wiley   +1 more source

Estrogen-dependent visceral hypersensitivity following stress in rats

Molecular Pain, 2016
We used functional MRI and a longitudinal design to investigate the brain mechanisms in a previously reported estrogen-dependent visceral hypersensitivity model. We hypothesized that noxious visceral stimulation would be associated with activation of the
Catherine S Hubbard PhD, Jane M Karpowicz BS, Andrew J Furman MS, Joyce Teixeira da Silva BS, David A Seminowicz PhD, Richard J Traub PhD   +5 more
doaj   +1 more source

A composite, host‐participatory haustorium links host compatibility to defence bifurcation in Alectra vogelii (Orobanchaceae)

PLANTS, PEOPLE, PLANET, EarlyView.
Parasitic weeds of the family Orobanchaceae are among the most damaging constraints on food production in the tropics, draining water and nutrients from their hosts and threatening the livelihoods of millions of smallholder farmers. Yellow witchweed (Alectra vogelii) can destroy entire legume harvests across sub‐Saharan Africa, where these crops are a ...
Hildah Kithinji, Guillaume Brun, Susann Wicke   +2 more
wiley   +1 more source

Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation

Molecular Pain, 2020
Background Irritable bowel syndrome is one of the most common gastrointestinal disorders. It is featured by abdominal pain in conjunction with altered bowel habits. However, the pathophysiology of the syndrome remains largely unknown.
Rui-Xia Weng, Wei Chen, Jia-Ni Tang, Qian Sun, Meng Li, Xue Xu, Ping-An Zhang, Ying Zhang, Chuang-Ying Hu, Guang-Yin Xu   +9 more
doaj   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

Phytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca, Emidio Scarpellini, Jan Tack, Pierluigi De Pierro, Giovanni Sarnelli, Giuseppe Esposito   +5 more
wiley   +1 more source

Biomaterial Platforms for Spatiotemporal Control of mRNA Delivery in Tissue Engineering and Regenerative Medicine: Design Rules, Therapeutic Applications, and Translational Roadmap

Small, EarlyView.
Biomaterial platforms can control where and when mRNA‐encoded proteins are expressed to support tissue repair. This Review proposes a cargo–target–timing framework linking therapeutic function, target tissues and cells, and expression profiles with carrier and scaffold design.
Huachun Pan, Shumin Yang, Katarina Holubova, Huifang Yin, Hongbo Chen, Xintian Zheng, Xiangan Han, Jinqiu Zhang, Xueping Li, Hui Zhang, Xiaojun Cai, Václav Slovák, Lihong Zhang, Quan Mo, Quazi T. H. Shubhra   +14 more
wiley   +1 more source

Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice

, 2017
Microbiota dysbiosis induced by defect of paneth cells triggers visceral hypersensitivity in mice.
Riba, Ambre, Sommer, Caroline, Ménard, Sandrine, Cartier, Christel, Olier, Maïwenn, Theodorou, Vassilia, Alquier-Bacquié, Valérie, Baron, Marine, Harkat, Cherryl, Laurent, Fabrice, Lencina, Corinne, Mallet, Virginie, Gillet, Marion, Lamandé, Sonia   +13 more
core   +3 more sources

NMDA receptor subunit expression and PAR2 receptor activation in colospinal afferent neurons (CANs) during inflammation induced visceral hypersensitivity

Molecular Pain, 2009
Background Visceral hypersensitivity is a clinical observation made when diagnosing patients with functional bowel disorders. The cause of visceral hypersensitivity is unknown but is thought to be attributed to inflammation.
Caudle Robert M, Suckow Shelby K
doaj   +1 more source

Intestinal Fungal Dysbiosis Associates With Visceral Hypersensitivity in Patients With Irritable Bowel Syndrome and Rats [PDF]

, 2017
BACKGROUND & AIMS: Visceral hypersensitivity is one feature of irritable bowel syndrome (IBS). Bacterial dysbiosis might be involved in activation of nociceptive sensory pathways, but there have been few studies of the role of the mycobiome (the ...
Schuren, F.H.J., Matteo Fornai, Masclee, A.A., Fornai, M., Sigrid E.M. Heinsbroek, Levin, Evgeni, Jonkers, Daisy M., Jonkers, Daisy M, de Jonge, Wouter J, Wouter J. de Jonge, de Weerd, Heleen H., Schuren, Frank H. J., Welting, O., Jonkers, D.M., de Jonge, W.J., Olaf Welting, Teun Boekhout, Evgeni Levin, Sara Botschuijver, Daisy M. Jonkers, FORNAI, MATTEO, Seppen, Jurgen, Heleen H. de Weerd, Boekhout, Teun, Frank H.J. Schuren, Roeselers, Guus, Seppen, J.; id_orcid, Levin, E., Heinsbroek, Sigrid Em, Schuren, Frank H. J, Welting, Olaf, Roeselers, G., Masclee, Ad A., Botschuijver, Sara, Guus Roeselers, de Weerd, H.H., Heinsbroek, Sigrid E. M., Botschuijver, S., René M. van den Wijngaard, de Jonge, Wouter J., Heinsbroek, S., van den Wijngaard, R.M., Ad A. Masclee, Boekhout, T., Jurgen Seppen, de Weerd, Heleen H, van den Wijngaard, Rene M., Masclee, Ad A   +47 more
core   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source